Salinispora oceanensis

General Information

Salinispora oceanensis is a fascinating marine bacterium that belongs to the family Micromonosporaceae. This organism is particularly interesting due to its unique ecological niche and its potential for natural product discovery. Salinispora oceanensis is found in marine sediments, often in tropical and subtropical regions, where it plays a crucial role in the microbial community. One of the most remarkable aspects of Salinispora oceanensis is its ability to produce a wide array of bioactive secondary metabolites. These compounds have garnered significant attention for their potential applications in medicine and biotechnology. For instance, Salinispora oceanensis has been shown to produce salinosporamide A, a potent proteasome inhibitor with promising anticancer properties. This compound has advanced to clinical trials, highlighting the organism's value in drug discovery. Additionally, Salinispora oceanensis exhibits a high degree of genomic plasticity, which allows it to adapt to various environmental conditions and potentially produce novel compounds. The genome of Salinispora oceanensis is rich in biosynthetic gene clusters, which are responsible for the synthesis of its diverse secondary metabolites. This genetic diversity makes it a valuable subject for genomic and metabolic engineering studies aimed at enhancing the production of existing compounds or discovering new ones. In summary, Salinispora oceanensis is a marine bacterium of significant interest due to its ecological role, ability to produce bioactive compounds, and genomic potential. Its contributions to natural product research and potential therapeutic applications make it a valuable organism for scientific exploration.

Salinispora oceanensis is a fascinating marine actinobacterium that was first isolated from a deep-sea sediment sample. This organism is particularly notable for its ability to produce a variety of bioactive secondary metabolites, which have garnered significant interest in the field of natural product research. One of the most remarkable aspects of S. oceanensis is its potential for pharmaceutical applications, as it has been shown to produce compounds with antimicrobial, antifungal, and anticancer properties. The unique ecological niche from which S. oceanensis is derived contributes to its distinct metabolic capabilities. It thrives in saline environments, which may influence the types of secondary metabolites it produces, making it a valuable organism for bioprospecting in the search for novel drugs. Research has indicated that the biosynthetic pathways of S. oceanensis are complex and diverse, leading to the production of unique compounds that are not found in terrestrial actinobacteria. Furthermore, the genome of S. oceanensis has been sequenced, revealing insights into its genetic makeup and the potential for genetic manipulation to enhance the production of valuable metabolites. This genomic information opens up avenues for synthetic biology approaches to optimize the yield of bioactive compounds. In summary, Salinispora oceanensis stands out as a promising candidate for drug discovery and a model organism for studying the biosynthesis of marine natural products, making it a significant focus of research in microbiology and pharmacology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Micromonosporales

Family: Micromonosporaceae

Genus: Salinispora

Species: Salinispora oceanensis

NCBI ID

1050199

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/383/575/GCA_000383575.1_ASM38357v1

File for sequence-based predictions:
GCA_000383575.1_ASM38357v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The marine actinomycete Salinispora oceanensis has garnered attention due to its potential clinical implications in human health and disease. This organism is known for its ability to produce a variety of bioactive compounds, including antibiotics and antitumor agents, which have been explored for their therapeutic applications. Notably, S. oceanensis has been identified as a source of the potent antibiotic salinosporamide A, which exhibits activity against certain cancer cell lines and has shown promise in preclinical studies for the treatment of multiple myeloma and other malignancies. In terms of pathogenicity, S. oceanensis is not typically associated with human infections; however, its close relatives within the genus Salinispora have been studied for their ecological roles and interactions with marine environments. The organism's ability to produce secondary metabolites suggests a complex interaction with its environment, which may have implications for immune response modulation in marine organisms. While S. oceanensis itself has not been directly linked to antimicrobial resistance issues, the exploration of its metabolites raises important questions about the sustainability of antibiotic use and the potential for discovering new classes of antibiotics that could circumvent existing resistance mechanisms. Furthermore, the study of S. oceanensis contributes to the broader understanding of marine microbiomes and their potential applications in biotechnology and pharmaceutical development. Overall, Salinispora oceanensis represents a significant area of interest in the search for novel therapeutic agents, highlighting the importance of marine microorganisms in the ongoing battle against infectious diseases and cancer.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The marine actinobacterium Salinispora oceanensis has garnered significant attention for its potential industrial applications across various sectors. One of the most notable areas is in pharmaceutical development, where Salinispora oceanensis has been shown to produce a variety of bioactive compounds, including the potent anticancer agent salinosporamide A. This compound is derived through fermentation processes, where the organism is cultivated under specific conditions to maximize the yield of these valuable metabolites. In addition to its pharmaceutical potential, Salinispora oceanensis plays a role in biotechnology through its ability to produce enzymes that can be utilized in various industrial processes. These enzymes can be harnessed for applications in biocatalysis, where they facilitate chemical reactions under mild conditions, making them suitable for green chemistry initiatives. Furthermore, the organism has demonstrated capabilities in waste management through its involvement in biodegradation processes. Salinispora oceanensis can break down complex organic materials, contributing to the bioremediation of polluted marine environments. This ability to degrade pollutants highlights its potential in developing sustainable waste treatment solutions. Lastly, the exploration of Salinispora oceanensis in biofuel production is an emerging area of interest. The organism's metabolic pathways can be optimized to produce lipids that may serve as precursors for biodiesel, thus contributing to renewable energy sources. Overall, Salinispora oceanensis exemplifies the diverse industrial applications of marine microorganisms, particularly in the fields of pharmaceuticals, biotechnology, waste management, and biofuels.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	google/gemini-flash-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	google/gemma-7b-it	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	true	false	true	false	true	false	true	false	false	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false
Host association	FALSE	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	true ✓	true ✓	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓
Hemolysis	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

Back to Search