Nonomuraea cypriaca

General Information

Nonomuraea cypriaca is a fascinating microorganism belonging to the genus Nonomuraea, which is part of the family Streptosporangiaceae. This genus is known for its complex life cycle and the production of a wide array of secondary metabolites. One of the most intriguing aspects of Nonomuraea cypriaca is its ability to produce novel antibiotics and bioactive compounds. These compounds have shown potential in combating multi-drug resistant pathogens, making Nonomuraea cypriaca a valuable subject for pharmaceutical research and development. Another unique feature of Nonomuraea cypriaca is its ecological versatility. It has been isolated from diverse environments, including soil and marine habitats, indicating its adaptability and potential role in various ecological processes. This adaptability also suggests that Nonomuraea cypriaca could be a source of enzymes with industrial applications, such as in bioremediation or the synthesis of complex organic molecules. Furthermore, the genetic makeup of Nonomuraea cypriaca is of significant interest. The organism's genome harbors numerous gene clusters responsible for the biosynthesis of its diverse secondary metabolites. Studying these gene clusters can provide insights into the genetic and enzymatic pathways involved in the production of these bioactive compounds, which can be harnessed for biotechnological applications. In summary, Nonomuraea cypriaca stands out due to its ability to produce novel antibiotics, its ecological versatility, and its rich genetic potential for secondary metabolite biosynthesis. These characteristics make it a valuable organism for ongoing research in microbiology, biotechnology, and pharmaceutical sciences.

Nonomuraea cypriaca is a fascinating actinobacterium that was first isolated from soil samples in Cyprus. This organism is particularly interesting due to its ability to produce a variety of bioactive compounds, which have significant implications for pharmaceutical research. One of the standout features of Nonomuraea cypriaca is its potential for antibiotic production, making it a valuable candidate for the discovery of new antimicrobial agents in an era where antibiotic resistance is a growing concern. The genus Nonomuraea is known for its complex secondary metabolite biosynthetic pathways, and Nonomuraea cypriaca is no exception. Research has indicated that this species can synthesize unique polyketides and other secondary metabolites, which may exhibit various biological activities, including antifungal and anticancer properties. This makes it a subject of interest for researchers looking to explore natural products as sources of new drugs. Additionally, Nonomuraea cypriaca has been studied for its ecological role in soil environments. Its ability to thrive in diverse soil conditions suggests that it may play a significant role in nutrient cycling and soil health, contributing to the overall biodiversity of microbial communities. This ecological aspect adds another layer of importance to the study of this organism, as understanding its interactions within the soil ecosystem can provide insights into sustainable agricultural practices. In summary, Nonomuraea cypriaca stands out not only for its potential in drug discovery but also for its ecological significance, making it a valuable organism for both pharmaceutical and environmental research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Streptosporangiales

Family: Streptosporangiaceae

Genus: Nonomuraea

Species: Nonomuraea cypriaca

NCBI ID

1187855

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/015/645/445/GCA_015645445.1_ASM1564544v1

File for sequence-based predictions:
GCA_015645445.1_ASM1564544v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The actinomycete Nonomuraea cypriaca is a notable microorganism primarily recognized for its potential in the field of antibiotic production. This organism has been isolated from soil samples in Cyprus and has shown promise in producing bioactive compounds that may have therapeutic applications. Clinical relevance arises from its ability to synthesize novel antibiotics, which could be crucial in the fight against antimicrobial resistance (AMR), a growing global health concern. In terms of pathogenicity, there is limited documentation of Nonomuraea cypriaca being directly associated with human infections. However, its close relatives within the Nonomuraea genus have been implicated in rare cases of opportunistic infections, particularly in immunocompromised individuals. This highlights the need for further research into its pathogenic potential and the mechanisms it may employ to evade the immune response. Moreover, the exploration of Nonomuraea cypriaca in the context of probiotics and therapeutics is an area of interest, as its metabolites may contribute to gut health or serve as a basis for developing new drugs. Overall, while Nonomuraea cypriaca is not widely recognized for direct clinical implications, its role in antibiotic discovery and potential therapeutic applications make it a significant organism in microbiological research.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Nonomuraea cypriaca is a species of actinobacteria that is primarily found in marine environments, particularly in the sediment of coastal areas. This microorganism thrives in brackish waters and is often associated with mangrove ecosystems, where it plays a significant role in nutrient cycling and organic matter decomposition. Its presence in these habitats contributes to the overall health of the ecosystem by breaking down complex organic materials, thus facilitating nutrient availability for other organisms. In addition to its role in decomposition, Nonomuraea cypriaca exhibits symbiotic relationships with various marine organisms, including certain types of algae and invertebrates. These interactions can enhance the growth and survival of its symbiotic partners, showcasing the importance of this microorganism in maintaining ecological balance. Furthermore, Nonomuraea cypriaca has demonstrated remarkable environmental adaptations, allowing it to withstand varying salinity levels and fluctuating temperatures typical of coastal habitats. This adaptability not only enables it to thrive in its native environments but also positions it as a potential candidate for biotechnological applications, particularly in the field of marine biotechnology. Overall, the ecological niche of Nonomuraea cypriaca is characterized by its decomposing abilities, symbiotic interactions, and environmental resilience, making it a vital component of the marine biome it inhabits.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Nonomuraea cypriaca has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where Nonomuraea cypriaca is recognized for its ability to produce a range of bioactive compounds, including antibiotics and other pharmaceuticals. This capability is particularly valuable in the development of new drugs, as the organism can be harnessed for fermentation processes that yield these bioactive metabolites. In the realm of waste management, Nonomuraea cypriaca has demonstrated effectiveness in biodegradation processes, where it can break down complex organic materials, thus contributing to the treatment of waste and the reduction of environmental pollutants. This property is essential for developing sustainable waste treatment solutions. Furthermore, the organism's enzymatic activity is of interest in biofuel production. Nonomuraea cypriaca can be utilized in enzyme production that aids in the conversion of biomass into biofuels, enhancing the efficiency of biofuel generation from renewable resources. Overall, the diverse capabilities of Nonomuraea cypriaca in these industrial sectors highlight its importance as a valuable microorganism in advancing sustainable practices and innovative solutions across multiple industries.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3.5-sonnet	google/gemini-pro	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/gemma-7b-it	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	false	true	true	false	true	true	false	false	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	false	false	true	true	true	true	false	false	false	false	true	true	false	false	false	false	false	false	true	true	true	true	false	false	true	true
Host association	N/A	true	false	false	true	false	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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