Micromonospora avicenniae

General Information

Micromonospora avicenniae is a fascinating microorganism belonging to the genus Micromonospora, which is well-known for its prolific production of bioactive compounds. This particular species was isolated from the roots of the mangrove plant Avicennia marina, highlighting its unique ecological niche. One of the most intriguing aspects of M. avicenniae is its potential for producing novel antibiotics and other secondary metabolites. The genus Micromonospora has historically been a rich source of clinically important antibiotics, such as gentamicin, and the discovery of M. avicenniae opens up new avenues for bioprospecting in mangrove ecosystems. Additionally, M. avicenniae exhibits a remarkable ability to thrive in the saline and often harsh conditions of mangrove environments, suggesting it possesses unique physiological adaptations that could be of interest for studies on extremophiles and salt tolerance mechanisms. The exploration of its genome could reveal genes responsible for these adaptations, providing insights into microbial survival strategies in extreme habitats. Overall, Micromonospora avicenniae stands out not only for its ecological origin but also for its potential contributions to biotechnology and pharmaceutical research, making it a valuable subject for further scientific investigation.

Micromonospora avicenniae is a fascinating actinobacterium that has garnered attention due to its unique ecological niche and potential biotechnological applications. This microorganism is primarily isolated from mangrove ecosystems, particularly associated with the roots of Avicennia species, which are known for their ability to thrive in saline environments. The association with mangroves not only highlights its ecological significance but also suggests a role in the degradation of organic matter in these complex habitats. One of the most interesting aspects of Micromonospora avicenniae is its ability to produce a variety of bioactive compounds. These secondary metabolites have been shown to exhibit antimicrobial, antifungal, and even anticancer properties, making this organism a valuable candidate for pharmaceutical research. The potential for discovering novel antibiotics is particularly crucial in the face of rising antibiotic resistance, and M. avicenniae could contribute significantly to this field. Additionally, the organism's adaptation to extreme environments such as those found in mangroves provides insights into microbial resilience and survival strategies. Studying Micromonospora avicenniae can enhance our understanding of microbial ecology in saline conditions and the evolutionary mechanisms that allow such organisms to thrive. In summary, Micromonospora avicenniae stands out not only for its ecological role in mangrove ecosystems but also for its potential contributions to medicine and biotechnology, making it a subject of interest for researchers in various fields.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Micromonosporales

Family: Micromonosporaceae

Genus: Micromonospora

Species: Micromonospora avicenniae

NCBI ID

1198245

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/156/065/GCA_900156065.1_IMG-taxon_2681813563_annotated_assembly

File for sequence-based predictions:
GCA_900156065.1_IMG-taxon_2681813563_annotated_assembly_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The actinobacterium Micromonospora avicenniae has garnered attention due to its potential clinical implications, particularly in the field of antimicrobial resistance. This organism is known to produce a variety of bioactive compounds, including antibiotics, which can be beneficial in treating certain infections. However, its role in human health is complex, as it has also been associated with opportunistic infections, particularly in immunocompromised individuals. Pathogenicity is a concern, as Micromonospora avicenniae can be isolated from clinical specimens, indicating its potential to cause disease under specific conditions. Furthermore, the organism's ability to produce antimicrobial agents raises questions about its interaction with other microbial communities, particularly in the context of dysbiosis and its implications for human health. The presence of Micromonospora avicenniae in various environments, including soil and marine ecosystems, suggests that it may play a role in the natural balance of microbial flora, which is crucial for maintaining immune homeostasis. In terms of immune evasion strategies, there is limited documentation on how Micromonospora avicenniae interacts with the human immune system, but its production of secondary metabolites may influence immune responses. The organism's potential involvement in outbreaks or specific infections remains an area of ongoing research, highlighting the need for further studies to fully understand its clinical relevance and applications in medicine, such as the development of new therapeutic agents or probiotics.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Micromonospora avicenniae is a notable actinobacterium primarily associated with mangrove ecosystems. These unique environments are characterized by their saline conditions and the presence of salt-tolerant trees, such as the Avicennia species, from which this microorganism derives its name. The ecological niche of Micromonospora avicenniae is often found in the rhizosphere of these mangrove plants, where it plays a crucial role in nutrient cycling and soil health. In this biome, Micromonospora avicenniae engages in symbiotic relationships with the roots of mangrove trees, aiding in the breakdown of organic matter and enhancing nutrient availability. This interaction is vital for the health of the mangrove ecosystem, as it supports plant growth and contributes to the overall productivity of the habitat. Additionally, Micromonospora avicenniae has been documented to exhibit antimicrobial properties, which can help in suppressing pathogenic microorganisms in the soil, thus promoting a balanced microbial community. Its ability to thrive in saline environments showcases its remarkable environmental adaptation, allowing it to withstand the osmotic stress associated with high salt concentrations. Overall, Micromonospora avicenniae is an integral component of the mangrove biome, contributing to both the ecological stability and the health of these vital coastal ecosystems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Micromonospora avicenniae has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for its ability to produce a range of bioactive compounds, including antibiotics. This capability is particularly valuable in the development of new pharmaceuticals, as the metabolites produced can lead to the discovery of novel therapeutic agents. In the realm of waste management, Micromonospora avicenniae has been studied for its role in biodegradation, particularly in the breakdown of complex organic materials. This makes it a candidate for use in bioremediation processes, where it can help in the detoxification of contaminated environments, such as soil and water. Additionally, this microorganism has potential applications in biofuel production. Its metabolic pathways can be harnessed to convert biomass into biofuels through fermentation, providing a sustainable alternative to fossil fuels. The efficiency of Micromonospora avicenniae in these processes can contribute to the development of cleaner energy sources. Overall, the diverse capabilities of Micromonospora avicenniae in pharmaceutical development, waste management, and biofuel production highlight its importance in modern industrial biotechnology, making it a valuable organism for future research and application.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3.5-sonnet	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	openchat/openchat-7b	anthropic/claude-3-haiku:beta	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	false	true	true	false	true	false	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	false	true	false	true	true	true	false	false	true	true	false	false	true	true	true	true	false	false	true	true	true	true	false	false
Host association	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus

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