Mycobacterium bourgelatii

General Information

Mycobacterium bourgelatii is a species of bacteria within the genus Mycobacterium, which is known for its complex cell wall structure rich in mycolic acids. This characteristic makes the genus particularly interesting for research into antibiotic resistance and pathogenicity. Mycobacterium bourgelatii is notable for its potential role in environmental and clinical settings, although it is less well-known compared to its infamous relatives like Mycobacterium tuberculosis and Mycobacterium leprae. One of the key characteristics of Mycobacterium bourgelatii is its slow growth rate, which is typical of many mycobacteria. This slow growth can complicate laboratory studies and clinical diagnosis, making it a subject of interest for developing more efficient diagnostic techniques. Additionally, the unique lipid-rich cell wall of Mycobacterium bourgelatii contributes to its resilience against many common disinfectants and antibiotics, posing challenges for infection control and treatment. From a research perspective, Mycobacterium bourgelatii offers valuable insights into the mechanisms of antibiotic resistance and host-pathogen interactions. Its ability to survive in harsh conditions and its potential to cause disease in immunocompromised individuals make it a significant organism for studying opportunistic infections. Furthermore, understanding the genetic and biochemical pathways that confer its resilience can inform the development of new therapeutic strategies and antimicrobial agents. In summary, Mycobacterium bourgelatii is a fascinating organism due to its complex cell wall structure, slow growth rate, and resilience to antibiotics and disinfectants. These features make it a valuable model for studying mycobacterial biology, antibiotic resistance, and the development of novel diagnostic and therapeutic approaches.

Mycobacterium bourgelatii is a species of the genus Mycobacterium that has garnered interest due to its unique ecological niche and potential implications in human health. This organism is primarily known for its ability to thrive in various environmental conditions, particularly in soil and water, which makes it an important player in the microbial ecosystem. Its resilience and adaptability to different environments highlight its evolutionary significance. One of the most intriguing aspects of M. bourgelatii is its genetic diversity, which can provide insights into the evolutionary mechanisms of the Mycobacterium genus. Research into its genome has revealed unique genetic markers that differentiate it from other closely related species, making it a valuable subject for studies on microbial evolution and phylogenetics. Additionally, M. bourgelatii has been studied for its potential role in bioremediation processes. Its ability to degrade complex organic compounds suggests that it could be harnessed for environmental cleanup efforts, particularly in contaminated sites. This capability not only underscores its ecological importance but also positions it as a candidate for biotechnological applications. Furthermore, there is ongoing research into the pathogenic potential of M. bourgelatii, particularly in immunocompromised individuals. Understanding its virulence factors and mechanisms of infection could provide critical insights into the broader implications of non-tuberculous mycobacterial infections. This aspect of M. bourgelatii makes it a significant organism for public health research, especially in the context of emerging infectious diseases. In summary, Mycobacterium bourgelatii stands out due to its ecological versatility, genetic diversity, potential biotechnological applications, and relevance to human health, making it a compelling subject for ongoing research in microbiology and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium bourgelatii

NCBI ID

1273442

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/025/821/955/GCF_025821955.1_ASM2582195v1

File for sequence-based predictions:
GCF_025821955.1_ASM2582195v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium bourgelatii is a member of the Mycobacterium genus, which is known for its clinical significance in human health. While it is less commonly associated with disease compared to its relatives, such as Mycobacterium tuberculosis, it has been implicated in certain infections and is of interest in the study of non-tuberculous mycobacterial (NTM) diseases. Clinical implications of M. bourgelatii include its potential role in pulmonary infections, particularly in immunocompromised patients or those with underlying lung conditions. The pathogenicity of M. bourgelatii is still being explored, but it is recognized as a possible opportunistic pathogen. Infections caused by this organism can lead to chronic respiratory symptoms, and it may be misidentified in laboratory settings, complicating diagnosis and treatment. In terms of antimicrobial resistance, there is limited data available, but like many mycobacteria, it may exhibit resistance to common antibiotics, which poses challenges in treatment. Understanding its resistance mechanisms is crucial for developing effective therapeutic strategies. Furthermore, M. bourgelatii is of interest in the context of immune response studies, as it may employ various strategies to evade the host's immune system, similar to other mycobacterial species. This includes the ability to survive within macrophages and modulate the host's immune response. Overall, while Mycobacterium bourgelatii is not as well-documented as other mycobacterial species, its potential role in human disease, particularly in specific populations, warrants further investigation to fully understand its clinical relevance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium bourgelatii is primarily associated with soil environments and aquatic habitats, where it plays a significant role in nutrient cycling and organic matter decomposition. This microorganism thrives in terrestrial ecosystems that are rich in organic material, often found in areas with high moisture content, such as wetlands and riverbanks. In these habitats, M. bourgelatii contributes to the breakdown of complex organic compounds, facilitating the release of nutrients back into the ecosystem. Its ability to degrade various substrates makes it an important player in the microbial community, promoting soil health and fertility. Additionally, M. bourgelatii has been observed in symbiotic relationships with certain plants, aiding in nutrient uptake and enhancing plant growth. This interaction underscores its role in plant-microbe interactions, which are crucial for maintaining the balance of ecosystems. Furthermore, this microorganism exhibits remarkable environmental adaptability, allowing it to survive in varying conditions, including fluctuations in temperature and moisture. Such resilience enables M. bourgelatii to persist in diverse biomes, contributing to the overall biodiversity and functionality of the environments it inhabits.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium bourgelatii has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to degrade complex organic compounds, making it valuable in biodegradation processes. For instance, it can be utilized in the treatment of contaminated environments, where it helps in the breakdown of pollutants, thus contributing to effective waste management strategies. In the realm of biofuel production, Mycobacterium bourgelatii has been studied for its metabolic pathways that can be harnessed to convert biomass into biofuels. The organism's unique enzymatic activities facilitate the conversion of lignocellulosic materials into fermentable sugars, which can then be further processed into bioethanol through fermentation. Moreover, in pharmaceutical development, Mycobacterium bourgelatii is of interest due to its potential in the production of bioactive compounds. Research has indicated that it may produce secondary metabolites that could have therapeutic properties, thus opening avenues for the development of new drugs. The organism's ability to synthesize these compounds can be optimized through fermentation techniques, enhancing yield and efficacy. Overall, Mycobacterium bourgelatii presents a multifaceted opportunity for industrial applications, particularly in biodegradation, biofuel production, and pharmaceutical development, making it a significant organism in the field of biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	anthropic/claude-3.5-sonnet	mistralai/mixtral-8x7b-instruct:nitro	anthropic/claude-3-haiku:beta	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/gemma-7b-it	google/gemma-7b-it	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	false	false	true	true	true	true	true	false	false	true	false	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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