Nonomuraea guangzhouensis

General Information

Nonomuraea guangzhouensis is a fascinating microorganism belonging to the genus Nonomuraea, which is part of the family Streptosporangiaceae. This bacterium is particularly interesting due to its ability to produce a variety of bioactive compounds. These compounds have shown potential in pharmaceutical applications, especially as antibiotics and anticancer agents. One of the most notable features of Nonomuraea guangzhouensis is its production of secondary metabolites. These metabolites are not only diverse but also possess unique chemical structures that make them valuable for drug discovery and development. Researchers have been particularly interested in the antimicrobial properties of these compounds, which could lead to the development of new antibiotics in the face of rising antibiotic resistance. Additionally, Nonomuraea guangzhouensis has been studied for its enzymatic activities, which are useful in various industrial applications. The enzymes produced by this bacterium can be employed in processes such as bioremediation, where they help in breaking down pollutants, and in the synthesis of complex organic molecules. The genetic makeup of Nonomuraea guangzhouensis also offers a rich area for research. Its genome contains numerous gene clusters responsible for the biosynthesis of its bioactive compounds. Understanding these gene clusters can provide insights into the biosynthetic pathways and help in the engineering of strains for enhanced production of desired compounds. In summary, Nonomuraea guangzhouensis is a microorganism of significant interest due to its bioactive compound production, enzymatic capabilities, and genetic potential. These characteristics make it a valuable subject for ongoing research in biotechnology and pharmaceuticals.

Nonomuraea guangzhouensis is a fascinating actinobacterium that was first isolated from a soil sample in Guangzhou, China. This organism is particularly notable for its ability to produce a variety of bioactive compounds, which have garnered significant interest in the fields of pharmaceuticals and biotechnology. One of the most remarkable aspects of Nonomuraea guangzhouensis is its potential for antibiotic production, making it a valuable candidate for the discovery of new antimicrobial agents. The secondary metabolites produced by this species include unique polyketides and other complex molecules that may exhibit significant therapeutic properties against various pathogens. In addition to its antibiotic capabilities, Nonomuraea guangzhouensis has been studied for its role in natural product biosynthesis, providing insights into the genetic and enzymatic pathways involved in the production of these valuable compounds. The genomic analysis of this organism reveals a rich repertoire of biosynthetic gene clusters, which suggests that it may have the potential to produce even more novel compounds that have yet to be discovered. Furthermore, the ecological role of Nonomuraea guangzhouensis in soil environments is of interest, as actinobacteria are known to play a crucial role in nutrient cycling and soil health. Understanding the interactions of this species with other microorganisms in its habitat can provide valuable information on microbial ecology and the development of sustainable agricultural practices. Overall, Nonomuraea guangzhouensis stands out as a promising organism for research in natural product chemistry, antibiotic discovery, and microbial ecology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Streptosporangiales

Family: Streptosporangiaceae

Genus: Nonomuraea

Species: Nonomuraea guangzhouensis

NCBI ID

1291555

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/019/396/345/GCA_019396345.1_ASM1939634v1

File for sequence-based predictions:
GCA_019396345.1_ASM1939634v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The actinomycete Nonomuraea guangzhouensis has garnered attention due to its potential clinical implications, particularly in the field of antimicrobial resistance. This organism is known to produce a variety of bioactive compounds, including antibiotics, which may have therapeutic applications. However, its role in human health is not fully understood, and it has been associated with certain infections in immunocompromised patients. The pathogenicity of Nonomuraea guangzhouensis is still under investigation, but its ability to evade the immune response through various mechanisms raises concerns about its impact on human health. Furthermore, the organism's potential for antimicrobial resistance poses challenges in treating infections, as it may harbor genes that confer resistance to commonly used antibiotics. Research into the medical applications of Nonomuraea guangzhouensis is ongoing, with a focus on its use in developing new therapeutics and understanding its ecological role in human-associated microbiomes.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Nonomuraea guangzhouensis is a species of actinobacteria that is primarily associated with soil ecosystems and marine environments. This microorganism thrives in nutrient-rich substrates, often found in tropical and subtropical regions, where it plays a significant role in the decomposition of organic matter. Its ability to degrade complex organic compounds makes it an important player in nutrient cycling within these biomes. In soil ecosystems, Nonomuraea guangzhouensis contributes to the health of the soil microbiome by participating in the breakdown of plant residues and other organic materials. This process not only enriches the soil but also enhances its structure and fertility, promoting plant growth. The organism often engages in symbiotic relationships with various soil-dwelling organisms, including fungi and other bacteria, which can lead to improved nutrient availability for plants. In marine environments, Nonomuraea guangzhouensis has been isolated from sediments and is believed to play a role in the degradation of organic materials in coastal ecosystems. Its presence in these habitats indicates its potential involvement in the biogeochemical cycles of carbon and nitrogen, contributing to the overall health of marine ecosystems. The organism's ability to adapt to varying salinity levels and its resilience in fluctuating environmental conditions highlight its ecological versatility. Overall, Nonomuraea guangzhouensis is a vital microorganism within its associated biomes, influencing both soil health and marine nutrient dynamics, showcasing the intricate connections within ecosystems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Nonomuraea guangzhouensis has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is recognized for its ability to produce a range of bioactive compounds, including antibiotics and enzymes. This capability is particularly valuable in the development of pharmaceuticals, as the metabolites derived from Nonomuraea guangzhouensis can be harnessed for drug discovery and development processes. In the realm of waste management, Nonomuraea guangzhouensis has demonstrated effectiveness in biodegradation processes. It can break down complex organic materials, making it useful in the treatment of industrial waste and the remediation of contaminated environments. This biodegradation ability is crucial for reducing environmental pollution and promoting sustainability. Furthermore, the organism has potential applications in biofuel production. Its metabolic pathways can be exploited to convert biomass into biofuels through fermentation processes, contributing to renewable energy solutions. The efficiency of Nonomuraea guangzhouensis in these processes can lead to more sustainable methods of energy production. Overall, Nonomuraea guangzhouensis stands out as a versatile microorganism with promising applications in pharmaceutical development, waste management, and biofuel production, showcasing its importance in advancing industrial biotechnology and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	google/gemma-7b-it	meta-llama/llama-3-8b-instruct:nitro	openchat/openchat-7b	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Gram staining	gram stain positive	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	false	false	true	false	false	true	false	true	true	false	true	true	false	false	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	N/A	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	true	true
Host association	N/A	true	false	false	false	false	false	false	false	true	false	true	true	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	spirillum ✗	spirillum ✗	bacillus ✓	bacillus ✓

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