Salinispora cortesiana

General Information

Source: gpt-4o-2024-05-13

Salinispora cortesiana is a fascinating marine actinobacterium that has garnered significant interest in the scientific community due to its unique ecological niche and its potential for natural product discovery. This microorganism is part of the genus Salinispora, which is known for its ability to produce a wide array of secondary metabolites with pharmaceutical potential. One of the most intriguing aspects of Salinispora cortesiana is its obligate marine lifestyle. Unlike many other actinobacteria, Salinispora species are strictly found in marine environments, which suggests that they have evolved specialized mechanisms to thrive in high-salinity conditions. This adaptation makes them a valuable subject for studying marine microbial ecology and the evolutionary processes that enable life in extreme environments. Salinispora cortesiana is particularly notable for its biosynthetic capabilities. It has been identified as a prolific producer of novel natural products, including antibiotics, anticancer agents, and other bioactive compounds. The discovery of these compounds has significant implications for drug development and biotechnology. For instance, the genus Salinispora has already yielded salinosporamide A, a potent proteasome inhibitor with promising applications in cancer therapy. Another unique feature of Salinispora cortesiana is its genomic architecture. The genome of this organism contains numerous gene clusters dedicated to the production of secondary metabolites, many of which are still uncharacterized. This genetic potential underscores the importance of Salinispora cortesiana as a source of new chemical entities that could lead to the development of novel therapeutics. In summary, Salinispora cortesiana stands out due to its marine specialization, rich secondary metabolite production, and genomic potential. These characteristics make it an invaluable resource for both ecological studies and the discovery of new natural products with significant biomedical applications.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Micromonosporales

Family: Micromonosporaceae

Genus: Salinispora

Species: Salinispora cortesiana

NCBI ID

1305843

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/484/695/GCA_000484695.1_ASM48469v1

File for sequence-based predictions:
GCA_000484695.1_ASM48469v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The marine actinomycete Salinispora cortesiana has garnered attention due to its potential clinical implications in human health and disease. This organism is known for its ability to produce a variety of bioactive compounds, including antibiotics and antitumor agents, which have been explored for therapeutic applications. Notably, Salinispora cortesiana has been identified as a source of the antibiotic salinosporamide A, which exhibits potent activity against certain cancer cell lines and has shown promise in preclinical studies for the treatment of multiple myeloma and other malignancies. In terms of pathogenicity, there is limited evidence suggesting that Salinispora cortesiana may be involved in human infections, particularly in immunocompromised individuals. However, its role as a pathogen is not well established, and further research is needed to clarify its clinical significance in infectious diseases. One of the critical areas of interest is the organism's potential for antimicrobial resistance. While specific resistance mechanisms have not been extensively documented for Salinispora cortesiana, the emergence of resistance in marine-derived microorganisms is a growing concern, particularly as they are explored for novel drug development. Additionally, the organism's interaction with the human microbiome and its potential as a probiotic or therapeutic agent is an area of ongoing research. Understanding how Salinispora cortesiana interacts with human cells and the immune system could provide insights into its possible applications in promoting health or preventing disease. In summary, while Salinispora cortesiana is primarily recognized for its bioactive compound production, its role in human health, disease associations, and immune evasion strategies remains an area ripe for exploration, with implications for both therapeutic development and understanding microbial interactions in health and disease.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The marine actinobacterium Salinispora cortesiana has garnered significant attention for its potential industrial applications across various sectors. Notably, it is recognized for its role in biotechnology, particularly in the production of bioactive compounds. This organism is known to produce a range of secondary metabolites, including antibiotics and anticancer agents, which are crucial in pharmaceutical development. For instance, compounds derived from Salinispora cortesiana have shown promising activity against various pathogens, making it a valuable resource in drug discovery and development. In the realm of waste management, Salinispora cortesiana has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property can be harnessed for the treatment of marine and coastal waste, contributing to environmental sustainability. Moreover, the organism's metabolic pathways are being explored for biofuel production. The ability of Salinispora cortesiana to metabolize various substrates can be utilized in fermentation processes to produce biofuels, offering a renewable energy source that can help reduce reliance on fossil fuels. Overall, Salinispora cortesiana exemplifies the potential of marine microorganisms in advancing biotechnology, enhancing waste management practices, and contributing to sustainable energy solutions.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	google/gemini-pro-1.5	google/gemini-pro	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta
Motility	FALSE	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain variable ✗	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	false	false	false	false	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	false	true	true	false	false	false	false	false	false	false	false	true	true	false	false	false	false	true	true	false	false	false	false	true	true
Host association	FALSE	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	spirillum	spirillum	bacillus	bacillus

Back to Search