Rhodococcus jostii

General Information

Rhodococcus jostii is a fascinating microorganism known for its remarkable metabolic versatility and biotechnological potential. One of the most noteworthy characteristics of R. jostii is its ability to degrade a wide range of organic compounds, including pollutants such as polycyclic aromatic hydrocarbons (PAHs), which makes it a valuable agent in bioremediation efforts. This species can transform complex organic molecules into simpler, less harmful substances, thereby contributing to environmental cleanup. Another unique feature of R. jostii is its capacity to produce a variety of bioactive compounds, including antibiotics and biosurfactants. These compounds have significant applications in medicine and industry, highlighting the organism's potential in drug discovery and development. From a research perspective, R. jostii is also interesting due to its robust genetic toolkit. The organism's genome has been sequenced, revealing numerous genes involved in the degradation of xenobiotic compounds and the synthesis of secondary metabolites. This genetic information provides a valuable resource for scientists aiming to engineer R. jostii for specific biotechnological applications. In addition, R. jostii exhibits a high degree of adaptability to different environmental conditions, which is partly attributed to its diverse metabolic pathways. This adaptability not only underscores its ecological significance but also enhances its utility in various industrial processes where conditions may fluctuate. Overall, Rhodococcus jostii stands out as a highly versatile and valuable microorganism with significant implications for environmental science, biotechnology, and industrial applications. Its ability to degrade pollutants, produce bioactive compounds, and adapt to diverse environments makes it a subject of ongoing scientific interest and research.

Rhodococcus jostii is a fascinating actinobacterium known for its remarkable metabolic versatility and ability to degrade a wide range of organic compounds, including complex hydrocarbons. This organism is particularly interesting due to its potential applications in bioremediation, where it can be utilized to clean up contaminated environments, such as oil spills and industrial waste sites. Its capacity to metabolize pollutants makes it a valuable asset in environmental microbiology and biotechnology. One of the unique features of R. jostii is its ability to utilize various carbon sources, including aromatic compounds, which are often resistant to degradation by other microorganisms. This trait is attributed to its diverse enzymatic arsenal, allowing it to break down complex molecules into simpler, less harmful substances. This enzymatic diversity not only highlights the organism's adaptability but also opens avenues for research into enzyme engineering and synthetic biology. Additionally, R. jostii has been studied for its potential in the production of valuable biochemicals, such as polyhydroxyalkanoates (PHAs), which are biodegradable plastics. The ability to produce these biopolymers from waste materials positions R. jostii as a promising candidate for sustainable bioprocessing. Furthermore, the genomic analysis of R. jostii has revealed insights into its metabolic pathways and regulatory mechanisms, making it a model organism for studying microbial metabolism and environmental interactions. The ongoing research into its genetic and biochemical properties continues to enhance our understanding of microbial ecology and the potential for harnessing microorganisms in industrial applications.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Nocardiaceae

Genus: Rhodococcus

Species: Rhodococcus jostii

NCBI ID

132919

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/033/042/455/GCA_033042455.1_ASM3304245v1

File for sequence-based predictions:
GCA_033042455.1_ASM3304245v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Rhodococcus jostii is a member of the genus Rhodococcus, which is known for its environmental versatility and ability to degrade a variety of organic compounds. While R. jostii is primarily recognized for its role in bioremediation, it has also been associated with human health and disease in certain contexts. Clinical implications of R. jostii include its potential as an opportunistic pathogen, particularly in immunocompromised individuals. Infections caused by R. jostii are rare but can lead to serious conditions such as pneumonia and soft tissue infections. The organism exhibits pathogenicity through its ability to evade the immune response, which may involve the production of virulence factors that help it survive within host tissues. Additionally, there are concerns regarding antimicrobial resistance, as some strains of R. jostii have shown resistance to multiple antibiotics, complicating treatment options for infections. Despite its pathogenic potential, R. jostii has also been explored for medical applications, particularly in the field of biotechnology. Its metabolic capabilities make it a candidate for the development of probiotics and other therapeutic agents aimed at enhancing human health. However, further research is needed to fully understand its role in human health and disease, as well as its potential benefits and risks in clinical settings.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Rhodococcus jostii is a versatile bacterium commonly found in a variety of terrestrial environments and aquatic ecosystems. This microorganism thrives particularly well in soil and sediment where it plays a crucial role in the degradation of organic pollutants, including hydrocarbons and other xenobiotic compounds. Its ability to metabolize these complex substances makes it an important player in bioremediation processes, helping to restore contaminated environments and maintain ecological balance. In soil ecosystems, Rhodococcus jostii often interacts with other microorganisms, forming a complex network of microbial communities. It can engage in symbiotic relationships with plants, enhancing nutrient availability and promoting plant health through its metabolic byproducts. This interaction is particularly significant in agricultural biomes, where it can contribute to soil fertility and crop productivity. Additionally, Rhodococcus jostii is known to inhabit marine environments, where it can be found in coastal sediments and mangrove ecosystems. Here, it contributes to the degradation of organic matter, playing a vital role in nutrient cycling and supporting the overall health of these ecosystems. Overall, Rhodococcus jostii exemplifies the adaptability of microorganisms to various biomes, showcasing its importance in both ecological functions and environmental remediation efforts.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Rhodococcus jostii has shown significant potential in various industrial applications due to its versatile metabolic capabilities. One of the most notable areas is in biotechnology, where Rhodococcus jostii is utilized for its ability to degrade a wide range of organic compounds, including pollutants. This makes it particularly valuable in biodegradation processes, where it can be employed to remediate contaminated environments, such as oil spills and industrial waste sites. In the realm of waste management, Rhodococcus jostii has been documented to effectively break down complex hydrocarbons, making it a candidate for bioremediation strategies aimed at cleaning up hazardous waste. Its enzymatic activity allows it to metabolize substances that are otherwise difficult to degrade, thus contributing to environmental sustainability. Furthermore, Rhodococcus jostii is also explored in biofuel production. Its ability to convert organic materials into usable energy sources through fermentation processes can lead to the development of more efficient biofuels. This is particularly relevant in the context of renewable energy, where the conversion of waste biomass into biofuels can help reduce reliance on fossil fuels. In the pharmaceutical development sector, Rhodococcus jostii has been studied for its potential in the production of valuable biochemicals and pharmaceuticals through enzyme production. The organism's unique metabolic pathways can be harnessed to synthesize complex molecules that are important in drug formulation. Overall, Rhodococcus jostii stands out as a versatile microorganism with promising applications across multiple industries, particularly in biodegradation, bioremediation, biofuel production, and pharmaceutical development.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro	google/gemini-pro	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta
Motility	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	N/A	aerotolerant ✗	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	false	true	true	true	true	false	false	true	true	false	false	true	true	false	false	true	true	false	false	false	false	true	true
Host association	FALSE	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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