Mycobacterium shottsii

General Information

Mycobacterium shottsii is a notable species within the genus Mycobacterium, primarily recognized for its association with fish diseases. This microorganism is particularly interesting due to its role in causing mycobacteriosis in striped bass (Morone saxatilis), a condition that has significant implications for both wild and farmed fish populations. Mycobacteriosis is characterized by granulomatous lesions in various organs, which can lead to severe health issues and high mortality rates in affected fish. One of the unique aspects of M. shottsii is its relatively slow growth rate compared to other mycobacteria, which can complicate its detection and study. This slow growth necessitates extended incubation periods for culture, making rapid diagnosis challenging. However, its slow-growing nature also provides a fascinating contrast to more rapidly proliferating mycobacterial species, offering insights into the diverse metabolic and physiological adaptations within the genus. From a research perspective, M. shottsii is valuable for studying host-pathogen interactions, particularly in aquatic environments. Understanding how this bacterium infects and persists in fish hosts can inform broader ecological and evolutionary studies of mycobacterial diseases. Additionally, research on M. shottsii can contribute to the development of better management practices and treatment strategies for mycobacteriosis in aquaculture, thereby supporting the sustainability of fish farming industries. In summary, Mycobacterium shottsii stands out due to its impact on fish health, its slow growth characteristics, and its importance in ecological and aquaculture research. These features make it a compelling subject for ongoing scientific investigation.

Mycobacterium shottsii is a species of mycobacteria that has garnered interest due to its unique ecological niche and potential implications in aquaculture. This organism was first isolated from the tissues of fish, particularly in the context of disease outbreaks, which highlights its role as a pathogen in aquatic environments. What makes M. shottsii particularly intriguing is its association with fish health, specifically in species such as the Atlantic salmon. The pathogenicity of M. shottsii is linked to its ability to cause mycobacterial infections, which can lead to significant economic losses in fish farming. This has prompted research into its mechanisms of virulence and host interaction, making it a valuable subject for studies aimed at understanding mycobacterial diseases in aquatic organisms. Furthermore, M. shottsii is part of a broader group of mycobacteria that are known for their complex lipid-rich cell walls, which contribute to their resilience and ability to survive in harsh environments. This characteristic not only aids in their survival but also poses challenges for treatment and management in aquaculture settings. Research into M. shottsii can provide insights into the evolution of mycobacterial species, their environmental adaptations, and their interactions with host organisms. As aquaculture continues to expand, understanding the dynamics of pathogens like M. shottsii becomes increasingly important for developing effective management strategies and ensuring the health of aquatic species.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium shottsii

NCBI ID

133549

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/010/728/525/GCA_010728525.1_ASM1072852v1

File for sequence-based predictions:
GCA_010728525.1_ASM1072852v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium shottsii is a member of the Mycobacterium genus, which is known for its clinical significance in human health. While M. shottsii is primarily associated with fish, particularly in aquaculture, its relevance to human health is still being explored. It has been implicated in infections in fish, which can have indirect effects on human health through the consumption of contaminated seafood. Pathogenicity in humans is not well-documented, but the potential for zoonotic transmission exists, warranting further investigation into its role as a possible pathogen. In terms of antimicrobial resistance, there is limited data available on M. shottsii, but the Mycobacterium genus is known for its ability to develop resistance to multiple drugs, which raises concerns about treatment options should it be found to cause human infections. The organism's interaction with the human body is not well characterized, but it is essential to monitor its potential immune evasion strategies and pathogenic mechanisms, especially in immunocompromised individuals. Currently, there are no known medical applications such as probiotics or vaccines associated with M. shottsii, but ongoing research may uncover its significance in broader ecological and health contexts. Overall, while M. shottsii is not a primary concern in human medicine at this time, its potential implications in disease associations and infections should not be overlooked, particularly in relation to food safety and public health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium shottsii is a species of bacterium that is primarily associated with aquatic environments, particularly in freshwater ecosystems. This microorganism has been documented in various habitats, including lakes, rivers, and wetlands, where it plays a significant role in the microbial community. Freshwater Biomes: In freshwater ecosystems, _Mycobacterium shottsii thrives in nutrient-rich environments, often found in sediment and biofilms. It is known to interact with other microorganisms, contributing to the decomposition of organic matter and nutrient cycling. This bacterium can also be involved in symbiotic relationships with aquatic plants and animals, aiding in their health and nutrient uptake. Ecological Role: The presence of _Mycobacterium shottsii in these biomes is crucial for maintaining the balance of microbial populations. It can act as a decomposer, breaking down complex organic materials, which in turn supports the food web by providing nutrients for other organisms. Additionally, its ability to adapt to varying environmental conditions, such as changes in temperature and nutrient availability, highlights its ecological resilience. Overall, _Mycobacterium shottsii is an important component of freshwater ecosystems, contributing to biodiversity and the overall health of aquatic environments.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium shottsii has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its role in biodegradation, where it can break down complex organic compounds, making it valuable in the treatment of contaminated environments. Its ability to degrade pollutants can be harnessed in waste treatment facilities, where it contributes to the detoxification of hazardous waste, thus promoting environmental sustainability. In the realm of biofuel production, Mycobacterium shottsii may play a role in the conversion of biomass into biofuels through fermentation processes. While specific pathways are still being researched, its metabolic capabilities suggest it could be involved in the breakdown of lignocellulosic materials, leading to the production of bioethanol or biogas. Furthermore, the organism's unique enzymatic activities could be explored for pharmaceutical development. The enzymes produced by Mycobacterium shottsii may have applications in drug synthesis or as biocatalysts in various chemical reactions, enhancing the efficiency and specificity of pharmaceutical manufacturing processes. Overall, Mycobacterium shottsii presents a promising avenue for innovation in biotechnology, waste management, and pharmaceutical industries, with its capabilities in biodegradation, fermentation, and enzyme production paving the way for sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	mistralai/mixtral-8x7b-instruct:nitro	openchat/openchat-7b	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemma-7b-it	google/gemma-7b-it	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	true	true	false	true	true	false	false	false	false	true	false	false	false	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	false	false	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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