Mycolicibacterium goodii

General Information

Mycolicibacterium goodii is a fascinating microorganism belonging to the genus Mycolicibacterium, which is part of the broader family of Mycobacteriaceae. This organism is particularly interesting due to its unique cell wall composition, which includes mycolic acids. These long-chain fatty acids contribute to the bacterium's resilience and its ability to survive in harsh environments. One of the most notable aspects of M. goodii is its clinical significance. It has been identified as an opportunistic pathogen, particularly in immunocompromised individuals. This makes it a subject of intense study in medical microbiology, as understanding its pathogenic mechanisms can lead to better treatment strategies for infections caused by this and related species. From a research perspective, M. goodii is valuable for its role in bioremediation. It has shown potential in breaking down complex hydrocarbons, making it a candidate for cleaning up oil spills and other environmental contaminants. This biodegradation capability is linked to its metabolic versatility, which allows it to utilize a wide range of organic compounds as energy sources. Additionally, M. goodii is of interest due to its genetic and biochemical properties. The organism's genome has been sequenced, providing insights into its metabolic pathways and potential for producing novel bioactive compounds. These compounds could have applications in pharmaceuticals, including the development of new antibiotics or anti-cancer agents. In summary, Mycolicibacterium goodii stands out due to its clinical relevance, environmental applications, and biotechnological potential. Its unique characteristics make it a valuable subject for ongoing research in multiple scientific fields.

Mycolicibacterium goodii is a species of actinobacteria that has garnered interest due to its unique biochemical properties and ecological significance. This organism is notable for its ability to produce mycolic acids, which are long-chain fatty acids that are characteristic of the genus Mycolicibacterium. These mycolic acids contribute to the organism's cell wall structure, providing a robust barrier that can enhance its survival in various environments, including extreme conditions. One of the most intriguing aspects of M. goodii is its potential role in bioremediation. The unique metabolic pathways of this bacterium allow it to degrade complex organic compounds, making it a candidate for use in the cleanup of contaminated environments. This capability is particularly valuable in addressing pollution from hydrocarbons and other toxic substances. Additionally, Mycolicibacterium goodii has been studied for its antimicrobial properties. Research has indicated that certain strains may produce compounds that inhibit the growth of pathogenic bacteria, which could have implications for developing new antibiotics. This aspect of M. goodii highlights its potential as a source of novel bioactive compounds that could be harnessed in pharmaceutical applications. Furthermore, the organism's genetic diversity and adaptability make it a fascinating subject for studies in evolutionary biology and microbial ecology. Understanding how M. goodii interacts with its environment and other microorganisms can provide insights into microbial community dynamics and the evolution of resistance mechanisms. In summary, Mycolicibacterium goodii stands out due to its unique biochemical characteristics, potential applications in bioremediation and antibiotic development, and its role in microbial ecology, making it a valuable organism for ongoing research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycolicibacterium

Species: Mycolicibacterium goodii

NCBI ID

134601

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/022/370/755/GCA_022370755.2_ASM2237075v2

File for sequence-based predictions:
GCA_022370755.2_ASM2237075v2_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycolicibacterium goodii is a member of the genus Mycolicibacterium, which is known for its complex lipid composition and unique cell wall structure. This microorganism has been associated with various clinical implications, particularly in the context of infections and immune response mechanisms. It has been identified as a potential pathogen in immunocompromised individuals, leading to pulmonary infections and cutaneous lesions. The pathogenicity of M. goodii is attributed to its ability to evade the host's immune response, which may involve the modulation of macrophage activity and the inhibition of phagocytosis. Furthermore, there is growing concern regarding its potential antimicrobial resistance, particularly against common antibiotics used to treat mycobacterial infections. This resistance complicates treatment options and necessitates further research into effective therapeutic strategies. In addition to its pathogenic potential, M. goodii may also have applications in the field of probiotics and therapeutics, although this area is still under investigation. Understanding the role of M. goodii in human health and disease is crucial for developing effective management strategies for infections associated with this organism.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycolicibacterium goodii has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to participate in biodegradation processes, which can be harnessed for the breakdown of complex organic materials in waste treatment facilities. By utilizing the enzymatic activity of Mycolicibacterium goodii, industries can enhance the efficiency of waste treatment systems, leading to reduced environmental impact and improved waste management practices. In the realm of biofuel production, Mycolicibacterium goodii can be involved in fermentation processes that convert biomass into biofuels. Its metabolic pathways may facilitate the conversion of lignocellulosic materials into fermentable sugars, which can then be transformed into ethanol or other biofuels, contributing to sustainable energy solutions. Furthermore, the organism's unique biochemical properties make it a candidate for pharmaceutical development. Research has indicated that Mycolicibacterium goodii may produce bioactive compounds with potential therapeutic applications, which could lead to the development of new drugs or treatments. Overall, Mycolicibacterium goodii represents a versatile microorganism with significant promise across multiple industries, particularly in enhancing biodegradation, optimizing biofuel production, and contributing to pharmaceutical innovations.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false	false	true	true	true	true	true	true	true	true	false	false
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	false ✗	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗
Health association	N/A	true	true	true	true	true	true	true	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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