Nocardia cyriacigeorgica

General Information

Nocardia cyriacigeorgica is a fascinating microorganism belonging to the genus Nocardia, which is known for its complex life cycle and ability to degrade a wide range of organic compounds. This species is particularly interesting due to its pathogenic potential in humans, often causing nocardiosis, a serious infection that can affect the lungs, brain, and skin. One of the unique features of N. cyriacigeorgica is its ability to survive in diverse environments, including soil and water, which makes it a subject of interest for environmental microbiologists. Its resilience is partly due to its complex cell wall structure, which provides protection against harsh conditions and contributes to its pathogenicity. From a research perspective, N. cyriacigeorgica is valuable because of its antibiotic resistance mechanisms. Studying these mechanisms can provide insights into how bacteria develop resistance and help in the development of new antibiotics. Additionally, this organism produces a variety of secondary metabolites, some of which have potential therapeutic applications. Another noteworthy aspect of N. cyriacigeorgica is its genetic diversity. The genome of this species contains numerous genes involved in the degradation of complex organic molecules, making it a potential candidate for bioremediation efforts. Researchers are particularly interested in its ability to break down pollutants and toxic compounds, which could have significant environmental benefits. In summary, Nocardia cyriacigeorgica is a microorganism of great interest due to its pathogenicity, environmental resilience, antibiotic resistance, and potential applications in bioremediation and drug development. Its study not only advances our understanding of bacterial survival and pathogenic mechanisms but also opens up new avenues for medical and environmental applications.

Nocardia cyriacigeorgica is a notable species within the genus Nocardia, which is known for its unique filamentous structure and its ability to thrive in various environments, including soil and decaying organic matter. This organism is particularly interesting due to its opportunistic pathogenicity, primarily affecting immunocompromised individuals, which makes it a subject of study in clinical microbiology and infectious disease research. One of the most remarkable aspects of N. cyriacigeorgica is its ability to degrade complex organic compounds, including hydrocarbons, which positions it as a potential candidate for bioremediation efforts. This characteristic is valuable in environmental microbiology, as it can contribute to the detoxification of polluted environments, particularly those contaminated with petroleum products. Additionally, N. cyriacigeorgica has been studied for its antibiotic resistance mechanisms, which are crucial for understanding how this organism survives in hostile environments and poses challenges in clinical settings. The insights gained from studying its resistance patterns can inform treatment strategies for infections caused by Nocardia species. Furthermore, the organism's unique lipid composition, particularly the presence of mycolic acids, is of interest in the field of microbiology. These lipids play a significant role in the bacterium's virulence and immune evasion strategies, making it a valuable model for studying host-pathogen interactions. In summary, Nocardia cyriacigeorgica stands out due to its dual role as an environmental degrader and an opportunistic pathogen, making it a significant focus for both environmental and medical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Nocardiaceae

Genus: Nocardia

Species: Nocardia cyriacigeorgica

NCBI ID

135487

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/949/635/GCF_002949635.1_ASM294963v1

File for sequence-based predictions:
GCF_002949635.1_ASM294963v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Nocardia cyriacigeorgica is a member of the genus Nocardia, which is known for its role in human health and disease. It is primarily associated with pulmonary infections, particularly in immunocompromised individuals. The bacterium can cause nocardiosis, a serious infection that can manifest as pneumonia, brain abscesses, and skin lesions. The clinical presentation often resembles that of tuberculosis, making accurate diagnosis crucial for effective treatment. One of the significant challenges in managing infections caused by Nocardia cyriacigeorgica is its antimicrobial resistance. This organism exhibits resistance to multiple antibiotics, including beta-lactams, which complicates treatment options. The standard treatment typically involves the use of sulfonamides, but resistance patterns can vary, necessitating susceptibility testing. In terms of immune evasion, Nocardia cyriacigeorgica has developed strategies to survive within host macrophages, which are key components of the immune response. This ability to evade destruction allows the bacteria to persist and cause chronic infections, particularly in individuals with weakened immune systems. While Nocardia cyriacigeorgica is primarily known for its pathogenic potential, there is ongoing research into its potential medical applications. Some species of Nocardia have been explored for their ability to produce bioactive compounds that may have therapeutic uses. However, the clinical implications of Nocardia cyriacigeorgica remain predominantly focused on its role as a pathogen, particularly in the context of opportunistic infections.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Nocardia cyriacigeorgica is a species of actinobacteria commonly found in various terrestrial environments and is particularly associated with soil ecosystems. This microorganism thrives in nutrient-rich soils and is often isolated from agricultural fields, forests, and urban soils. Its ability to degrade complex organic compounds allows it to play a crucial role in the nutrient cycling process, contributing to soil health and fertility. In terms of ecological interactions, Nocardia cyriacigeorgica is known for its symbiotic relationships with plants, where it can enhance plant growth by improving nutrient availability. This bacterium can also exhibit antimicrobial properties, which may help in suppressing soil-borne pathogens, thus promoting a healthier ecosystem. Furthermore, Nocardia cyriacigeorgica is adapted to survive in drier conditions and can tolerate a range of pH levels, making it a resilient organism in fluctuating environments. Its presence in contaminated soils also highlights its potential in bioremediation, where it can assist in the breakdown of pollutants, thereby contributing to environmental restoration efforts. Overall, Nocardia cyriacigeorgica is a vital component of its native biomes, influencing both soil dynamics and plant health.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Nocardia cyriacigeorgica has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for its ability to degrade complex organic compounds, making it valuable in waste management processes. This organism can effectively break down pollutants in contaminated environments, contributing to bioremediation efforts aimed at restoring ecological balance. In the realm of biofuel production, Nocardia cyriacigeorgica has been studied for its capacity to metabolize hydrocarbons, which can be harnessed to produce biofuels from waste materials. The organism's enzymatic activity plays a crucial role in the fermentation processes that convert organic substrates into usable energy sources. Furthermore, this microorganism has potential applications in pharmaceutical development. Its unique metabolic pathways can lead to the discovery of novel compounds with antimicrobial properties, which are essential in the fight against resistant bacterial strains. The ability of Nocardia cyriacigeorgica to produce specific enzymes can also be exploited in the development of new drugs and therapeutic agents. Overall, Nocardia cyriacigeorgica demonstrates a multifaceted role in industrial biotechnology, particularly in biodegradation, waste treatment, and the production of bioactive compounds, making it a valuable organism for sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	openchat/openchat-7b	google/gemini-pro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	false	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Hemolysis	N/A	N/A	gamma	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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