Streptomyces lushanensis

General Information

Streptomyces lushanensis is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most intriguing aspects of S. lushanensis is its ability to produce a variety of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it a valuable subject of study in the field of natural product chemistry and pharmaceutical research. Streptomyces species are well-known for their complex life cycle and filamentous growth, which is reminiscent of fungal hyphae. This characteristic allows them to thrive in diverse environments, particularly in soil where they play a crucial role in decomposing organic matter and recycling nutrients. The production of geosmin, a compound responsible for the earthy smell of soil, is another notable feature of Streptomyces species, including S. lushanensis. From a genetic perspective, S. lushanensis possesses a large and complex genome, which encodes a vast array of biosynthetic gene clusters. These clusters are responsible for the synthesis of its diverse secondary metabolites. The study of these gene clusters not only provides insights into the biosynthetic pathways of these valuable compounds but also opens up possibilities for genetic engineering to enhance or modify the production of specific metabolites. In summary, Streptomyces lushanensis is a microorganism of significant interest due to its ability to produce a wide range of bioactive compounds, its complex life cycle, and its genetic potential for biotechnological applications. Its contributions to natural product discovery and its ecological role in soil environments underscore its importance in both scientific research and practical applications.

Streptomyces lushanensis is a fascinating actinobacterium that was first isolated from soil in Lushan, China. This organism is particularly notable for its ability to produce a diverse array of bioactive compounds, which makes it a valuable resource in pharmaceutical research. The secondary metabolites derived from S. lushanensis have shown promising antimicrobial, antifungal, and anticancer properties, highlighting its potential in drug discovery and development. One of the unique aspects of S. lushanensis is its genetic capacity for secondary metabolite biosynthesis. The genome of this species contains numerous gene clusters that are predicted to encode for various natural products, including polyketides and non-ribosomal peptides. This genetic diversity not only contributes to its ecological role in soil but also positions it as a target for biotechnological applications. Furthermore, S. lushanensis has been studied for its environmental resilience, showcasing its ability to thrive in various soil conditions. This adaptability may provide insights into the mechanisms of survival and competition among soil microorganisms, which is crucial for understanding soil health and ecosystem dynamics. In summary, Streptomyces lushanensis stands out due to its rich biosynthetic potential, environmental adaptability, and importance in natural product research, making it a significant organism for both ecological studies and biotechnological innovations.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces lushanensis

NCBI ID

1434255

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/700/515/GCF_001700515.1_ASM170051v1

File for sequence-based predictions:
GCF_001700515.1_ASM170051v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces lushanensis is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This species has been studied for its potential in antimicrobial applications, particularly due to its ability to produce various secondary metabolites that exhibit antimicrobial activity against a range of pathogens. Clinical implications of Streptomyces lushanensis include its potential use in the development of new therapeutics for treating infections caused by antibiotic-resistant bacteria. In addition to its therapeutic potential, Streptomyces lushanensis may also play a role in human health through its contributions to the microbiome, although specific studies on its interactions with human hosts are limited. The genus Streptomyces is known for its complex life cycle and ability to form spores, which may aid in immune evasion strategies, allowing it to survive in various environments. While there are no well-documented outbreaks or infections directly associated with Streptomyces lushanensis, its relatives have been implicated in various environmental and clinical settings. The study of this organism may provide insights into the development of probiotics or other beneficial applications in medicine, particularly in the context of microbial therapies aimed at restoring healthy microbiota. Overall, the exploration of Streptomyces lushanensis holds promise for future research in antimicrobial resistance and the discovery of novel compounds that could enhance human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces lushanensis is a species of actinobacteria that is primarily found in soil ecosystems and decaying organic matter. This microorganism thrives in environments rich in organic material, where it plays a crucial role in the decomposition process. Its ability to produce a variety of bioactive compounds makes it significant in the nutrient cycling of these habitats, contributing to soil fertility and health. In its natural habitat, Streptomyces lushanensis engages in antibiotic production, which helps it compete with other microorganisms for resources. This competitive advantage allows it to establish itself in diverse ecological niches, particularly in temperate forests and grasslands, where it can be found in association with plant roots, contributing to plant health through its interactions. Moreover, Streptomyces lushanensis is known for its role in symbiotic relationships with various plants, aiding in nutrient uptake and enhancing plant resistance to pathogens. This symbiosis is particularly important in agricultural ecosystems, where the presence of such beneficial microorganisms can lead to improved crop yields and reduced reliance on chemical fertilizers. Overall, the ecological significance of Streptomyces lushanensis in its biomes underscores its importance in maintaining the balance of soil ecosystems and promoting sustainable agricultural practices.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces lushanensis has shown significant potential in various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is renowned for its ability to produce a wide range of bioactive compounds, including antibiotics and enzymes, which are crucial in the pharmaceutical industry. For instance, it has been documented to produce compounds that exhibit antimicrobial properties, making it a valuable resource for the development of new antibiotics through fermentation processes. In the realm of biotechnology, Streptomyces lushanensis is utilized for its enzymatic activities, particularly in the production of enzymes that can be applied in various industrial processes. These enzymes can be harnessed for applications such as biocatalysis, where they facilitate chemical reactions under mild conditions, thus reducing the need for harsh chemicals and energy-intensive processes. Moreover, this microorganism plays a role in waste management through its ability to degrade complex organic materials. Its enzymatic capabilities allow it to break down pollutants and organic waste, contributing to biodegradation processes that are essential for environmental cleanup and sustainability. Overall, Streptomyces lushanensis exemplifies the versatility of actinobacteria in industrial applications, particularly through its contributions to fermentation, enzyme production, and biodegradation, making it a significant organism in the pursuit of sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	google/gemini-flash-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	false	true	false	false	true	true	false	false	true	true	true	false	false	true	true	false	false	true	true	false	false	false	false	true	true
Host association	N/A	true	true	true	false	true	false	true	true	false	true	false	false	false	false	false	false	false	false	false	true	true	false	false	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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