Mycolicibacterium neworleansense

General Information

Mycolicibacterium neworleansense is a fascinating microorganism that belongs to the genus Mycolicibacterium. This genus is known for its complex and unique cell wall structure, which includes mycolic acids, contributing to its resilience and distinctive characteristics. One of the most intriguing aspects of M. neworleansense is its potential role in bioremediation. This species has shown promise in breaking down environmental pollutants, making it a valuable candidate for cleaning up contaminated sites. Additionally, Mycolicibacterium neworleansense is of significant interest in medical research due to its close relation to other Mycolicibacterium species that are known to cause opportunistic infections in humans. Studying M. neworleansense can provide insights into the pathogenic mechanisms and potential treatments for infections caused by related species. From a biochemical perspective, M. neworleansense exhibits a unique metabolic profile that allows it to thrive in diverse environments. This adaptability is partly due to its ability to utilize a wide range of carbon sources, which is a trait that can be harnessed for various industrial applications, including the production of biofuels and bioplastics. In summary, Mycolicibacterium neworleansense stands out due to its bioremediation potential, medical research relevance, and industrial application possibilities. Its unique cell wall structure and metabolic versatility make it a microorganism of considerable interest across multiple fields of study.

Mycolicibacterium neworleansense is a fascinating species of actinobacteria that was first isolated from a human clinical sample in New Orleans, Louisiana. This organism is particularly interesting due to its unique biochemical properties and its potential implications in human health. One of the most notable characteristics of M. neworleansense is its ability to produce mycolic acids, which are long-chain fatty acids that are a hallmark of the genus Mycolicibacterium. These mycolic acids contribute to the organism's cell wall structure, providing it with a distinctive resilience against environmental stresses and antibiotics. The ecological niche of M. neworleansense is also noteworthy. It has been found in various environmental samples, suggesting that it may play a role in the degradation of complex organic materials. This capability makes it a potential candidate for bioremediation applications, where it could be utilized to break down pollutants in contaminated environments. From a research perspective, M. neworleansense offers valuable insights into the evolution and adaptation of actinobacteria. Its genetic makeup and metabolic pathways are of particular interest, as they may reveal mechanisms of resistance to antimicrobial agents, which is a growing concern in medical microbiology. Furthermore, studying this organism can enhance our understanding of the diversity within the Mycolicibacterium genus and its relatives, potentially leading to the discovery of novel compounds with therapeutic properties. In summary, Mycolicibacterium neworleansense stands out due to its unique biochemical features, ecological significance, and potential applications in both environmental science and medicine. Its study could pave the way for new discoveries in microbial ecology and antibiotic resistance.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycolicibacterium

Species: Mycolicibacterium neworleansense

NCBI ID

146018

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/025/823/025/GCF_025823025.1_ASM2582302v1

File for sequence-based predictions:
GCF_025823025.1_ASM2582302v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycolicibacterium neworleansense is a member of the genus Mycolicibacterium, which is known for its association with various clinical implications. This microorganism has been identified as a potential pathogen, particularly in immunocompromised individuals. Clinical relevance includes its role in infections that can manifest in the lungs, skin, and other tissues, often resembling those caused by more well-known mycobacterial species such as Mycobacterium tuberculosis. One of the significant concerns regarding Mycolicibacterium neworleansense is its potential for antimicrobial resistance. Strains of this organism have shown resistance to multiple classes of antibiotics, complicating treatment options for affected patients. This resistance is particularly alarming in the context of rising global rates of antibiotic resistance, which poses a challenge for public health. In terms of immune evasion, Mycolicibacterium neworleansense may employ strategies similar to those of other mycobacteria, such as the ability to survive within macrophages, thereby avoiding detection and destruction by the host's immune system. This characteristic can lead to chronic infections that are difficult to treat. While research is ongoing, there is potential for Mycolicibacterium neworleansense to be explored in the context of medical applications, such as the development of novel therapeutics or vaccines targeting mycobacterial infections. However, more studies are needed to fully understand its pathogenic mechanisms and interactions with the human body. Overall, the clinical implications of Mycolicibacterium neworleansense underscore the importance of continued surveillance and research into emerging mycobacterial pathogens.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycolicibacterium neworleansense is a species of actinobacteria that is primarily associated with soil environments and marine ecosystems. This microorganism thrives in nutrient-rich substrates, often found in areas with high organic matter content, such as decaying plant material and sediments in coastal regions. Its presence is particularly noted in brackish waters, where it plays a significant role in the degradation of organic compounds, contributing to nutrient cycling within these ecosystems. In terms of ecological interactions, Mycolicibacterium neworleansense exhibits decompositional activity, breaking down complex organic materials and thus facilitating the availability of nutrients for other organisms. This process is crucial for maintaining the health of the soil microbiome and supporting plant growth. Additionally, this microorganism may engage in symbiotic relationships with other microbial communities, enhancing the overall biodiversity and resilience of its habitat. Its ability to adapt to varying salinity levels in marine environments showcases its ecological versatility, allowing it to thrive in both freshwater and saltwater conditions. Overall, Mycolicibacterium neworleansense is an important player in its respective biomes, contributing to ecological balance and nutrient dynamics.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycolicibacterium neworleansense has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is notable for its ability to participate in biodegradation processes, which can be harnessed for the breakdown of complex organic materials in waste treatment facilities. By utilizing the enzymatic activity of Mycolicibacterium neworleansense, industries can improve the efficiency of waste treatment systems, leading to reduced environmental impact and enhanced resource recovery. In the realm of biofuel production, Mycolicibacterium neworleansense may contribute to the conversion of biomass into biofuels through fermentation processes. This microorganism can potentially metabolize various substrates, producing valuable biofuels while minimizing waste. Its unique metabolic pathways could be explored to optimize the yield of biofuels, making it a candidate for further research in sustainable energy solutions. Additionally, the pharmaceutical industry may benefit from the bioactive compounds produced by Mycolicibacterium neworleansense. The organism's ability to synthesize unique metabolites could lead to the development of new drugs or therapeutic agents, particularly in the fight against antibiotic-resistant bacteria. The exploration of its enzyme production capabilities could also yield novel enzymes for use in various biotechnological applications, including biocatalysis and bioremediation. Overall, Mycolicibacterium neworleansense presents a promising avenue for innovation across multiple industries, leveraging its natural processes for enhanced sustainability and efficiency.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	true	true	false	true	false	true	false	false	false	false	true	true	false	false	false	false	true	true	false	false	false	false	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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