Streptomyces reticuliscabiei

General Information

Streptomyces reticuliscabiei is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of antibiotics and other secondary metabolites. This particular species is notable for its role in plant pathology, specifically as a causative agent of common scab in potatoes and other root crops. What makes S. reticuliscabiei particularly interesting is its ability to produce thaxtomin A, a phytotoxin that is crucial for its pathogenicity. Thaxtomin A disrupts plant cell wall synthesis, leading to the characteristic scab lesions on tubers and roots. From a research perspective, S. reticuliscabiei is valuable for several reasons. Firstly, its pathogenic mechanisms provide insights into plant-microbe interactions and the molecular basis of plant diseases. Understanding how S. reticuliscabiei infects plants can lead to the development of resistant crop varieties or new agricultural treatments. Secondly, like other Streptomyces species, it has a complex secondary metabolism that can be harnessed for the discovery of new bioactive compounds. The study of its genome and metabolic pathways can reveal novel enzymes and biochemical processes that have potential applications in biotechnology and medicine. Moreover, S. reticuliscabiei serves as a model organism for studying the evolution of pathogenicity within the Streptomyces genus. Comparative genomics between pathogenic and non-pathogenic Streptomyces species can shed light on the genetic adaptations that enable certain strains to infect plants. This knowledge is crucial for both basic science and practical applications in agriculture and biotechnology. In summary, Streptomyces reticuliscabiei is a microorganism of significant interest due to its role in plant disease, its production of unique secondary metabolites, and its utility in research on microbial pathogenicity and secondary metabolism.

Streptomyces reticuliscabiei is a fascinating actinobacterium known for its unique ecological role and biotechnological potential. This species is part of the diverse genus Streptomyces, which is renowned for its ability to produce a wide array of bioactive compounds, including antibiotics, antifungals, and immunosuppressants. What makes S. reticuliscabiei particularly interesting is its ability to degrade complex organic materials, which contributes to nutrient cycling in soil ecosystems. The organism has been isolated from various environments, including soil and decaying plant matter, showcasing its adaptability and ecological significance. Its metabolic versatility allows it to thrive in diverse habitats, making it a valuable model for studying microbial ecology and the interactions within soil microbiomes. Moreover, S. reticuliscabiei has garnered attention in the field of natural product research. The potential for discovering novel secondary metabolites from this species could lead to the development of new pharmaceuticals, particularly in the fight against antibiotic-resistant pathogens. Researchers are particularly interested in its genetic and biochemical pathways, which may reveal insights into the mechanisms of antibiotic production and resistance. In summary, Streptomyces reticuliscabiei stands out not only for its ecological contributions but also for its promising applications in biotechnology and medicine, making it a subject of ongoing research and exploration.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces reticuliscabiei

NCBI ID

146821

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/154/675/GCF_002154675.1_ASM215467v1

File for sequence-based predictions:
GCF_002154675.1_ASM215467v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces reticuliscabiei is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. While S. reticuliscabiei is not commonly associated with human disease, its relevance in clinical microbiology primarily stems from its potential as a source of novel antimicrobial agents. Antibiotic production by this organism can be crucial in the fight against antimicrobial resistance, a growing concern in clinical settings. In addition to its antibiotic properties, S. reticuliscabiei may also play a role in soil health and plant growth promotion, which indirectly impacts human health through food security and agricultural sustainability. The organism's ability to produce various secondary metabolites can influence the microbiome of the soil, potentially affecting the microbial diversity that contributes to plant health. While there are no well-documented cases of S. reticuliscabiei causing infections in humans, the genus Streptomyces has been implicated in rare cases of opportunistic infections, particularly in immunocompromised individuals. Understanding the pathogenic potential and immune evasion strategies of related species can provide insights into the risks associated with environmental exposure to S. reticuliscabiei. Overall, the clinical implications of Streptomyces reticuliscabiei lie more in its potential applications in therapeutics and probiotics rather than direct pathogenicity, making it a subject of interest for future research in microbiology and pharmacology.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces reticuliscabiei is a species of bacterium that thrives primarily in soil ecosystems, particularly in nutrient-rich environments. This microorganism is commonly found in agricultural soils where it plays a crucial role in the decomposition of organic matter, contributing to nutrient cycling and soil health. Its ability to produce a variety of bioactive compounds makes it significant in the rhizosphere, where it interacts with plant roots and other soil microorganisms. In these soil habitats, S. reticuliscabiei engages in symbiotic relationships with plants, promoting growth and enhancing resistance to pathogens. This bacterium is known for its ability to produce antibiotics, which can inhibit the growth of harmful bacteria, thus playing a protective role in the ecosystem. Additionally, S. reticuliscabiei is often associated with decaying plant material and compost, where it contributes to the breakdown of complex organic compounds. Its presence in these environments not only aids in nutrient release but also supports the overall biodiversity of the microbial community. Overall, Streptomyces reticuliscabiei is an essential component of terrestrial biomes, particularly in agricultural and forest soils, where it enhances soil fertility and plant health through its various ecological interactions.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces reticuliscabiei is known for its significant contributions to various industrial applications. One of the primary areas of interest is in biotechnology, where this organism is utilized for its ability to produce a wide range of bioactive compounds, including antibiotics and enzymes. These compounds are crucial in the development of pharmaceuticals, particularly in the fight against bacterial infections. The fermentation process employed by Streptomyces reticuliscabiei allows for the efficient production of these valuable metabolites. In the realm of waste management, Streptomyces reticuliscabiei has demonstrated potential in the biodegradation of complex organic materials. Its enzymatic activity enables the breakdown of pollutants, making it a candidate for bioremediation efforts aimed at cleaning contaminated environments. This capability is particularly important in the treatment of industrial waste, where the organism can help mitigate the impact of hazardous substances. Furthermore, the role of Streptomyces reticuliscabiei in biofuel production is noteworthy. The organism can be involved in the decomposition of lignocellulosic biomass, facilitating the conversion of agricultural waste into fermentable sugars, which can then be transformed into biofuels. This process not only contributes to sustainable energy solutions but also promotes the circular economy by utilizing waste materials. Overall, Streptomyces reticuliscabiei showcases a diverse range of applications across pharmaceutical development, biotechnology, waste management, and biofuel production, highlighting its importance in modern industrial processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	mistralai/mistral-7b-instruct	google/palm-2-chat-bison-32k	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	false	true	false	true	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	false	true	false	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	FALSE	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	TRUE	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	coccus ✗	coccus ✗	bacillus ✗	bacillus ✗

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