Streptomyces parvulus

General Information

Streptomyces parvulus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most noteworthy characteristics of S. parvulus is its ability to produce a variety of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it an invaluable resource in the field of pharmaceutical research and biotechnology. Streptomyces parvulus is particularly interesting due to its production of actinomycin D, a potent antibiotic and anticancer compound. Actinomycin D has been extensively studied and utilized in clinical settings for its ability to inhibit DNA transcription, making it effective against certain types of cancer. The biosynthetic pathways involved in the production of actinomycin D by S. parvulus have been a subject of intense research, providing insights into the complex mechanisms of natural product biosynthesis. Another unique aspect of S. parvulus is its complex life cycle, which includes the formation of mycelium and spores. This life cycle is typical of the Streptomyces genus and contributes to its ability to thrive in diverse environments, including soil and decaying organic matter. The organism's ability to degrade complex organic compounds also highlights its ecological importance in nutrient cycling and soil health. From a genetic perspective, S. parvulus has a large and complex genome, which encodes a vast array of enzymes and regulatory proteins. This genetic diversity underpins its metabolic versatility and capacity to produce a wide range of secondary metabolites. Advances in genomic and metagenomic technologies have enabled researchers to explore the genetic potential of S. parvulus in greater detail, opening up new avenues for the discovery of novel bioactive compounds. In summary, Streptomyces parvulus is a microorganism of significant interest due to its ability to produce medically important compounds, its complex life cycle, and its ecological role. Its contributions to natural product chemistry and biotechnology continue to make it a valuable subject of scientific research.

Streptomyces parvulus is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, making it a valuable organism in pharmaceutical and agricultural research. This species is part of the larger genus Streptomyces, which is renowned for its role in natural antibiotic production. One of the most interesting aspects of S. parvulus is its capacity to synthesize unique secondary metabolites that exhibit antimicrobial properties, which can be harnessed for developing new antibiotics. The organism thrives in soil environments, contributing to the natural ecosystem by participating in the decomposition of organic matter. Its ability to degrade complex organic compounds is not only crucial for nutrient cycling but also positions S. parvulus as a potential candidate for bioremediation applications. Researchers are particularly interested in its genetic makeup, as it contains a wealth of biosynthetic gene clusters that could lead to the discovery of novel compounds. Furthermore, S. parvulus has been studied for its role in plant growth promotion, showcasing its potential as a biofertilizer. This dual functionality—acting as both a source of antibiotics and a promoter of plant health—highlights the organism's significance in sustainable agriculture. Overall, Streptomyces parvulus stands out as a promising organism for further exploration in the fields of microbiology, pharmacology, and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces parvulus

NCBI ID

146923

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/660/045/GCF_001660045.1_ASM166004v1

File for sequence-based predictions:
GCF_001660045.1_ASM166004v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces parvulus is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. While S. parvulus itself is not commonly associated with human disease, its relatives have been implicated in various clinical contexts. Antimicrobial resistance is a notable concern, as many Streptomyces species have developed mechanisms to resist antibiotics, which can complicate treatment options for infections caused by other pathogens. In terms of human health, S. parvulus and its close relatives are often studied for their potential as probiotics, contributing to gut health and possibly enhancing the immune response against certain pathogens. The production of secondary metabolites by S. parvulus has been explored for therapeutic applications, including the development of new antibiotics to combat resistant bacterial strains. Furthermore, the organism's ability to produce enzymes and other compounds may have implications in bioremediation and agricultural applications, although these are not directly linked to human health. Overall, while S. parvulus may not be a primary pathogen, its role in antibiotic production and potential applications in medicine underscore its relevance in the broader context of microbial interactions with human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces parvulus is a species of bacteria that thrives primarily in soil ecosystems, particularly in nutrient-rich environments. This microorganism is commonly found in terrestrial biomes where it plays a crucial role in the decomposition of organic matter. Its ability to break down complex organic compounds contributes significantly to nutrient cycling within these ecosystems, making it an essential player in maintaining soil health and fertility. In addition to its role in decomposition, Streptomyces parvulus is known for its production of various antibiotics and other bioactive compounds, which can inhibit the growth of competing microorganisms. This characteristic not only aids in its survival but also influences the microbial community structure in its habitat, showcasing its role in microbial interactions and competition. Furthermore, Streptomyces parvulus exhibits a remarkable ability to adapt to varying environmental conditions, including changes in moisture and nutrient availability. This adaptability allows it to thrive in diverse habitats, from agricultural soils to natural grasslands, where it can form symbiotic relationships with plants, enhancing their growth and resistance to pathogens. Overall, the ecological niche of Streptomyces parvulus is characterized by its contributions to soil health, its interactions with other microorganisms, and its potential applications in agriculture and medicine due to its antibiotic properties.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces parvulus is known for its significant contributions to various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is recognized for its ability to produce a wide range of bioactive compounds, including antibiotics, which are crucial in the pharmaceutical industry. For instance, it has been documented to produce substances that exhibit antimicrobial properties, making it a valuable resource in the development of new antibiotics through fermentation processes. In the realm of biotechnology, Streptomyces parvulus is utilized for its enzymatic activities, particularly in the production of enzymes that can be applied in various industrial processes. These enzymes can be harnessed for applications such as biocatalysis, where they facilitate chemical reactions under mild conditions, thus reducing the need for harsh chemicals and energy-intensive processes. Moreover, Streptomyces parvulus plays a role in waste management through its ability to degrade complex organic materials. This capability is particularly useful in biodegradation processes, where the organism can help in the breakdown of pollutants and organic waste, contributing to environmental sustainability. Overall, the diverse metabolic capabilities of Streptomyces parvulus make it a promising candidate for various industrial applications, particularly in the production of valuable compounds and the management of waste through biodegradation and fermentation.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	google/gemini-flash-1.5	google/palm-2-chat-bison-32k	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	google/gemini-pro	google/gemma-7b-it	mistralai/mistral-7b-instruct	perplexity/llama-3-sonar-small-32k-chat	anthropic/claude-3-haiku:beta	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Gram staining	gram stain positive	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	false	false	true	false	false	true	true	false	true	true	false	false	false	false	true	true	true	true	true	true	true	true	true	true	false	false
Host association	FALSE	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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