Mycolicibacterium holsaticum

General Information

Mycolicibacterium holsaticum is a fascinating microorganism belonging to the genus Mycolicibacterium, which is known for its complex and unique cell wall structure rich in mycolic acids. This characteristic makes the organism particularly interesting for research in the field of microbiology and biochemistry. One of the key features of M. holsaticum is its ability to degrade a variety of complex organic compounds, which has significant implications for bioremediation. This capability allows it to break down pollutants in the environment, making it a valuable organism for cleaning up contaminated sites. Additionally, M. holsaticum has been studied for its potential in the production of bioactive compounds. These compounds can have various applications, including the development of new antibiotics and other pharmaceuticals. The organism's metabolic pathways are of great interest because they can lead to the discovery of novel substances with therapeutic potential. From a taxonomic perspective, M. holsaticum is part of the broader group of mycobacteria, which includes notable pathogens like Mycobacterium tuberculosis. However, unlike its pathogenic relatives, M. holsaticum is generally considered non-pathogenic, making it a safer model organism for laboratory studies. In summary, Mycolicibacterium holsaticum stands out due to its bioremediation potential, production of bioactive compounds, and its role as a non-pathogenic model organism. These attributes make it a valuable subject for ongoing and future research in various scientific fields.

Mycolicibacterium holsaticum is a fascinating species within the genus Mycolicibacterium, which is known for its unique lipid composition and ecological versatility. This organism is particularly interesting due to its ability to produce mycolic acids, which are long-chain fatty acids that play a crucial role in the structural integrity of the cell wall. These mycolic acids contribute to the organism's resilience against environmental stressors, making it a subject of interest in studies related to microbial survival and adaptation. One of the standout features of M. holsaticum is its potential biotechnological applications. The unique lipid profile of this species can be harnessed for the development of novel antimicrobial agents or as a source of bioactive compounds. Researchers are exploring its metabolic pathways to identify enzymes that could be utilized in bioremediation processes or in the synthesis of valuable biochemicals. Additionally, M. holsaticum has been isolated from diverse environments, including soil and aquatic systems, which highlights its ecological significance. Understanding its role in these ecosystems can provide insights into microbial interactions and nutrient cycling. The organism's adaptability to various habitats makes it a valuable model for studying microbial ecology and evolution. In summary, Mycolicibacterium holsaticum stands out due to its unique biochemical properties, potential for biotechnological applications, and ecological importance, making it a promising candidate for further research in microbiology and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycolicibacterium

Species: Mycolicibacterium holsaticum

NCBI ID

152142

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/722/355/GCF_001722355.1_ASM172235v1

File for sequence-based predictions:
GCF_001722355.1_ASM172235v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycolicibacterium holsaticum is a member of the genus Mycolicibacterium, which is known for its complex lipid composition and potential pathogenicity. While specific clinical implications of M. holsaticum are still being explored, it is important to note that members of this genus can be associated with various infections and may exhibit opportunistic pathogenicity in immunocompromised individuals. The organism's ability to produce mycolic acids contributes to its resistance against certain antimicrobial agents, making treatment challenging. Furthermore, its interaction with the human immune system may involve immune evasion strategies, allowing it to persist in host tissues. There is ongoing research into the role of M. holsaticum in human health, particularly in relation to its potential use in probiotics or as a model for studying mycobacterial infections. However, more studies are needed to fully understand its clinical relevance and implications in disease associations.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycolicibacterium holsaticum is a species of actinobacteria that is primarily associated with soil environments and marine ecosystems. This microorganism thrives in nutrient-rich substrates, often found in areas with high organic matter content. Its ecological niche is characterized by the ability to degrade complex organic compounds, playing a crucial role in the nutrient cycling of these habitats. In soil biomes, Mycolicibacterium holsaticum contributes to the breakdown of organic materials, thus facilitating the release of essential nutrients back into the ecosystem. This process is vital for maintaining soil health and fertility, supporting plant growth and the overall productivity of terrestrial ecosystems. The organism's ability to form symbiotic relationships with other soil microorganisms enhances its effectiveness in nutrient cycling and soil structure improvement. In marine environments, this bacterium has been identified in sediments and biofilms, where it participates in the degradation of organic matter. Its presence in these habitats indicates its role in the decomposition processes that are essential for the health of marine ecosystems. By breaking down organic pollutants and contributing to the microbial loop, Mycolicibacterium holsaticum helps maintain the balance of marine nutrient cycles. Overall, Mycolicibacterium holsaticum exemplifies the importance of microorganisms in both terrestrial and aquatic biomes, highlighting their roles in ecological interactions, nutrient cycling, and environmental adaptation.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycolicibacterium holsaticum has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to participate in biodegradation processes, which can be harnessed for the treatment of contaminated environments. For instance, Mycolicibacterium holsaticum can break down complex organic compounds, making it valuable in waste treatment facilities where organic waste needs to be processed efficiently. In the realm of biofuel production, Mycolicibacterium holsaticum may contribute to the conversion of biomass into biofuels through fermentation processes. This capability allows for the transformation of agricultural waste into renewable energy sources, thus promoting sustainability. Moreover, the organism's unique metabolic pathways can be explored for pharmaceutical development, particularly in the production of bioactive compounds. These compounds may have therapeutic properties, making Mycolicibacterium holsaticum a candidate for further research in drug discovery and development. Overall, the diverse applications of Mycolicibacterium holsaticum in biodegradation, fermentation, and the production of valuable metabolites highlight its significance in advancing industrial biotechnology and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-pro	google/gemini-flash-1.5	google/gemini-pro-1.5	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemma-7b-it	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	true	true	true	false	true	false	false	false	false	false	false	false	false	false	false	true	true	false	false	true	true	false	false	false	false
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 3 ✗
Health association	N/A	true	true	true	false	true	true	false	true	true	true	false	false	true	true	false	false	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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