Kribbella italica

General Information

Kribbella italica is a fascinating microorganism belonging to the genus Kribbella, which is part of the family Nocardioidaceae. This bacterium is particularly interesting due to its unique ecological niche and biotechnological potential. One of the most notable characteristics of Kribbella italica is its ability to thrive in extreme environments, such as high-altitude soils and cold climates. This adaptability makes it a subject of interest for studies on extremophiles and their survival mechanisms. From a biotechnological perspective, Kribbella italica has shown promise in the degradation of complex organic compounds. This capability is valuable for applications in bioremediation, where the bacterium can be used to clean up contaminated environments by breaking down pollutants that are otherwise difficult to manage. Additionally, Kribbella italica produces a variety of secondary metabolites with potential pharmaceutical applications. These compounds can have antimicrobial, antifungal, or anticancer properties, making the bacterium a potential source of new drugs. In summary, Kribbella italica stands out due to its extreme habitat adaptability, bioremediation potential, and production of bioactive compounds, making it a valuable organism for both environmental and medical research.

Kribbella italica is a fascinating member of the Actinobacteria phylum, notable for its unique ecological niche and potential biotechnological applications. This microorganism was first isolated from soil samples in Italy, which is reflected in its name. One of the most interesting aspects of K. italica is its ability to produce a variety of secondary metabolites, including antimicrobial compounds. This characteristic makes it a valuable organism for research in the field of natural product chemistry, as scientists explore its potential for developing new antibiotics and other therapeutic agents. Additionally, K. italica has been studied for its role in soil health and nutrient cycling. Its presence in the soil ecosystem contributes to the degradation of organic matter, which is essential for maintaining soil fertility. This ecological function highlights the importance of K. italica in sustainable agriculture and environmental management. Furthermore, the genomic analysis of K. italica has revealed insights into its metabolic pathways, which could lead to advancements in bioremediation strategies. The organism's ability to degrade pollutants and its resilience in various environmental conditions make it a subject of interest for researchers aiming to harness its capabilities for environmental cleanup. In summary, Kribbella italica stands out due to its antimicrobial production, role in soil ecology, and potential applications in bioremediation, making it a significant organism for both ecological and pharmaceutical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Propionibacteriales

Family: Kribbellaceae

Genus: Kribbella

Species: Kribbella italica

NCBI ID

1540520

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/014/205/135/GCA_014205135.1_ASM1420513v1

File for sequence-based predictions:
GCA_014205135.1_ASM1420513v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Kribbella italica is a member of the Actinobacteria phylum and has been studied for its potential clinical implications. While it is not widely recognized as a primary pathogen, it has been isolated from various clinical specimens, suggesting a possible role in infections in immunocompromised patients. Its presence in human samples raises questions about its potential pathogenicity and the conditions under which it may contribute to disease. One of the notable aspects of Kribbella italica is its antimicrobial resistance profile. Some strains have shown resistance to common antibiotics, which complicates treatment options for infections where this organism is involved. This resistance may be attributed to the organism's ability to produce beta-lactamases or other resistance mechanisms, making it essential for clinicians to consider when diagnosing and treating infections. In terms of immune evasion, Kribbella italica may possess strategies that allow it to survive in the human host, although specific mechanisms are not yet fully understood. Its interactions with the human immune system could potentially lead to chronic infections or contribute to the dysbiosis of the microbiome, particularly in patients with underlying health conditions. Currently, there are no established medical applications such as probiotics or vaccines directly associated with Kribbella italica. However, ongoing research into its biochemical properties may reveal future therapeutic potentials. Overall, while Kribbella italica is not a common pathogen, its clinical relevance cannot be overlooked, especially in the context of infections in vulnerable populations and the growing concern of antimicrobial resistance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Kribbella italica is a member of the Actinobacteria phylum, commonly found in a variety of terrestrial and aquatic environments. This microorganism is particularly associated with soil ecosystems, where it plays a crucial role in nutrient cycling and organic matter decomposition. Its presence in these habitats contributes to the overall health and fertility of the soil, making it an important player in maintaining soil biodiversity. In addition to soil, Kribbella italica has been isolated from marine environments, indicating its adaptability to different salinity levels and nutrient availability. In these aquatic habitats, it may engage in symbiotic relationships with other microorganisms, contributing to the microbial community's stability and functionality. Furthermore, Kribbella italica is known for its ability to produce various bioactive compounds, which can have significant ecological implications. These compounds may serve as antimicrobial agents, helping to regulate microbial populations and prevent the overgrowth of pathogenic species in its environment. Overall, Kribbella italica thrives in diverse biomes, including temperate forests, grasslands, and coastal regions, showcasing its ecological versatility and importance in both terrestrial and aquatic ecosystems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Kribbella italica has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where Kribbella italica is utilized for its ability to produce a range of bioactive compounds, including antimicrobial agents. This property is particularly valuable in the development of new pharmaceuticals, as these compounds can serve as lead structures for drug discovery. In the realm of waste management, Kribbella italica has demonstrated capabilities in biodegradation, effectively breaking down complex organic materials. This makes it a candidate for use in bioremediation processes, where it can help in the detoxification of contaminated environments, such as soil and water, by degrading pollutants. Furthermore, Kribbella italica has been explored for its role in biofuel production. Its metabolic pathways can be harnessed in fermentation processes to convert biomass into biofuels, such as ethanol or biodiesel. This application is particularly relevant in the context of sustainable energy solutions, where microbial fermentation can provide an alternative to fossil fuels. Overall, the versatility of Kribbella italica in these industrial sectors highlights its importance as a microorganism with promising applications in pharmaceutical development, waste treatment, and renewable energy production.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	mistralai/mistral-7b-instruct	google/gemma-7b-it	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	mistralai/mixtral-8x7b-instruct:nitro	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain negative ✗	gram stain variable ✗	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	anaerobic ✗	aerotolerant ✗	N/A	N/A	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	false	false	true	true	true	true	false	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	false	false	false	false
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	true	false	false	false	true	true	true	true	false	false	false	false	false	false	false	false	false	false	true	true	true	true	false	false
Host association	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Hemolysis	N/A	N/A	N/A	alpha	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus	coccus	coccus

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