Mycolicibacterium malmesburyense

General Information

Mycolicibacterium malmesburyense is a fascinating microorganism belonging to the genus Mycolicibacterium. This genus is known for its complex and unique cell wall structure, which includes mycolic acids, contributing to its resilience and distinctive characteristics. One of the most intriguing aspects of M. malmesburyense is its potential role in bioremediation. Bioremediation is the process by which microorganisms are used to degrade or detoxify environmental contaminants, and M. malmesburyense has shown promise in this area due to its ability to metabolize a variety of organic compounds. Another notable feature of M. malmesburyense is its slow growth rate, which is a common trait among mycobacteria. This slow growth can be a double-edged sword; while it makes the organism less competitive in rapidly changing environments, it also allows for more stable and prolonged metabolic processes, which can be advantageous in certain ecological niches. From a research perspective, M. malmesburyense is valuable due to its phylogenetic relationship with other mycobacteria, including pathogenic species such as Mycobacterium tuberculosis. Studying M. malmesburyense can provide insights into the evolution, genetics, and physiology of mycobacteria as a whole. This can lead to a better understanding of pathogenic mechanisms and the development of new therapeutic strategies. In summary, Mycolicibacterium malmesburyense is a microorganism of significant interest due to its potential applications in bioremediation, its unique metabolic capabilities, and its relevance to the broader study of mycobacteria. Its distinctive characteristics make it a valuable subject for ongoing and future research.

Mycolicibacterium malmesburyense is a fascinating species of actinobacteria that has garnered attention due to its unique biochemical properties and ecological significance. This microorganism is notable for its ability to produce mycolic acids, which are long-chain fatty acids that play a crucial role in the structure of its cell wall, contributing to its resilience and adaptability in various environments. One of the most interesting aspects of M. malmesburyense is its potential for biotechnological applications. The mycolic acids produced by this organism can be utilized in the development of novel antimicrobial agents, as they exhibit properties that can inhibit the growth of various pathogens. This makes M. malmesburyense a valuable candidate for research in the field of drug discovery and development. Additionally, M. malmesburyense has been isolated from unique ecological niches, which raises questions about its role in those environments. Its presence in specific habitats suggests that it may have specialized metabolic pathways that allow it to thrive under conditions that are inhospitable to many other microorganisms. This adaptability not only makes it a subject of interest for ecological studies but also for understanding microbial diversity and evolution. Furthermore, the organism's genetic makeup is of particular interest to researchers. The study of its genome can provide insights into the evolutionary relationships within the Mycolicibacterium genus and help elucidate the mechanisms behind its unique biochemical capabilities. This can lead to a better understanding of how similar organisms might be harnessed for environmental or medical applications. In summary, Mycolicibacterium malmesburyense stands out due to its biochemical uniqueness, potential for biotechnological innovations, and its role in microbial ecology. These characteristics make it a promising subject for ongoing research and exploration.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycolicibacterium

Species: Mycolicibacterium malmesburyense

NCBI ID

1566886

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/050/015/GCF_001050015.1_Mycobacterium_malmesburii_WCM_7299

File for sequence-based predictions:
GCF_001050015.1_Mycobacterium_malmesburii_WCM_7299_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycolicibacterium malmesburyense is a member of the genus Mycolicibacterium, which is known for its complex lipid composition and potential pathogenicity. While specific clinical implications of M. malmesburyense are still being explored, it is closely related to other mycobacterial species that have significant relevance in human health. Infections caused by mycobacteria can range from benign to severe, with some species being associated with tuberculosis and non-tuberculous mycobacterial infections (NTM). The pathogenicity of M. malmesburyense may involve mechanisms similar to those of other mycobacteria, including the ability to evade the immune response through the modulation of host cell signaling pathways and the production of mycolic acids that inhibit phagocytosis. This immune evasion strategy is critical for the survival and persistence of mycobacteria within the host. Furthermore, there is a growing concern regarding antimicrobial resistance among mycobacterial species, which complicates treatment options. Resistance mechanisms may include the upregulation of efflux pumps and mutations in target genes, leading to reduced susceptibility to commonly used antibiotics. In terms of medical applications, while M. malmesburyense itself may not yet be utilized in probiotics or vaccines, the study of its interactions with the human microbiome and immune system could provide insights into potential therapeutic strategies. Understanding its role in the context of other mycobacterial infections may also contribute to the development of new treatment modalities or preventive measures against related diseases. Overall, while the clinical implications of Mycolicibacterium malmesburyense are still under investigation, its relationship with other pathogenic mycobacteria highlights the importance of continued research in understanding its role in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycolicibacterium malmesburyense is a species of actinobacteria that is primarily associated with soil environments and marine ecosystems. This microorganism thrives in nutrient-rich substrates, often found in areas with high organic matter content, such as decaying plant material and sediments. Its ecological niche is characterized by its ability to degrade complex organic compounds, playing a crucial role in the nutrient cycling of these environments. In soil biomes, M. malmesburyense contributes to the breakdown of organic matter, facilitating the release of nutrients back into the soil, which supports plant growth and overall soil health. This process is vital for maintaining the balance of the ecosystem, as it helps in the formation of humus and improves soil structure. In marine environments, this microorganism has been identified in sediments and biofilms, where it interacts with other microbial communities. It may engage in symbiotic relationships with other microorganisms, enhancing the degradation of organic materials and contributing to the overall health of the marine ecosystem. Its presence in these habitats indicates its adaptability to varying salinity and nutrient levels, showcasing its role in bioremediation processes, particularly in areas impacted by pollution. Overall, Mycolicibacterium malmesburyense exemplifies the intricate relationships within its biomes, highlighting its importance in ecosystem functioning and environmental adaptation.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycolicibacterium malmesburyense has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycolicibacterium malmesburyense may play a role in the conversion of biomass into biofuels through fermentation processes. By utilizing its metabolic pathways, this microorganism can potentially enhance the efficiency of biofuel generation from organic waste materials. Furthermore, there is interest in the pharmaceutical development sector, where Mycolicibacterium malmesburyense could be explored for its unique metabolic products. These metabolites may have applications in drug formulation or as bioactive compounds, although more research is needed to fully understand its capabilities in this area. Overall, the versatility of Mycolicibacterium malmesburyense in biodegradation, fermentation, and potential pharmaceutical applications highlights its significance in sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	true	true	true	true	true	true	true	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false	false	false
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	TRUE	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	false	true	true	true	true	true	true	true	true	true	false	false	true	true	false	false	true	true	false	false	true	true	false	false	false	false
Host association	TRUE	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗

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