Staphylococcus pragensis

General Information

Staphylococcus pragensis is a relatively recent addition to the genus Staphylococcus, which is known for its diverse range of species, many of which are significant in both clinical and environmental contexts. This particular species was first isolated and described in 2014 from a human clinical specimen in Prague, Czech Republic, which is reflected in its name. One of the key characteristics of S. pragensis is its ability to thrive in a variety of environments, which makes it an interesting subject for studies on microbial adaptability and resilience. This adaptability is particularly noteworthy given the increasing interest in understanding how bacteria can survive and proliferate in diverse and often hostile environments. From a research perspective, S. pragensis is valuable due to its potential role in human health. While it is not as well-known or as extensively studied as Staphylococcus aureus, it provides a unique opportunity to explore the genetic and phenotypic diversity within the Staphylococcus genus. This can lead to insights into the mechanisms of pathogenicity, antibiotic resistance, and host interaction. Moreover, the study of S. pragensis can contribute to the broader understanding of microbial ecology and evolution. By examining how this species interacts with other microorganisms and its environment, researchers can gain a deeper understanding of microbial communities and their dynamics. In summary, Staphylococcus pragensis stands out due to its recent discovery, its adaptability, and its potential implications for human health and microbial ecology. These characteristics make it a fascinating subject for ongoing and future research endeavors.*

Staphylococcus pragensis is a relatively newly identified species within the Staphylococcus genus, which is known for its diverse range of pathogenic and non-pathogenic members. This organism was first described in 2016 and has since garnered interest due to its unique genetic and biochemical characteristics that differentiate it from other closely related species, such as Staphylococcus aureus and Staphylococcus epidermidis. One of the most notable features of S. pragensis is its ability to produce a variety of extracellular enzymes, which may play a role in its pathogenicity and adaptability in different environments. This enzymatic activity can include proteases and lipases, which are important for nutrient acquisition and may contribute to its survival in various ecological niches. Furthermore, S. pragensis has been isolated from clinical samples, indicating its potential as an opportunistic pathogen. Its genetic makeup reveals unique sequences that may provide insights into the evolution of staphylococcal species and their resistance mechanisms. This makes S. pragensis a valuable subject for research in microbial genetics and antibiotic resistance. The organism's metabolic versatility allows it to thrive in diverse environments, which is particularly interesting for studies on microbial ecology and the role of staphylococci in human health and disease. Understanding the interactions of S. pragensis with the human microbiome could lead to new perspectives on its role in health and disease, especially in immunocompromised individuals. In summary, Staphylococcus pragensis stands out due to its unique enzymatic capabilities, genetic characteristics, and potential clinical significance, making it a compelling subject for further research in microbiology and infectious diseases.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Bacilli

Order: Bacillales

Family: Staphylococcaceae

Genus: Staphylococcus

Species: Staphylococcus pragensis

NCBI ID

1611836

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/004/785/665/GCF_004785665.1_ASM478566v1

File for sequence-based predictions:
GCF_004785665.1_ASM478566v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Staphylococcus pragensis is a coagulase-negative staphylococcus (CoNS) that has been increasingly recognized in clinical settings. It is primarily associated with nosocomial infections, particularly in immunocompromised patients or those with indwelling medical devices. Its role in biofilm formation on medical implants can lead to persistent infections that are difficult to treat. Clinical implications include its potential to cause bacteremia, endocarditis, and skin infections, especially in patients with underlying health conditions. One of the significant concerns regarding Staphylococcus pragensis is its antimicrobial resistance. Many strains exhibit resistance to multiple antibiotics, including methicillin, which complicates treatment options. This resistance is often attributed to the acquisition of resistance genes and the ability to form biofilms, which protect the bacteria from both the host immune response and antibiotic action. In terms of immune evasion strategies, Staphylococcus pragensis can produce various virulence factors, such as exoproteins and adhesins, that facilitate its survival and persistence in the host. These factors can inhibit phagocytosis and modulate the host's immune response, allowing the bacteria to evade detection and clearance. While Staphylococcus pragensis is not commonly associated with outbreaks, its presence in clinical specimens highlights the need for ongoing surveillance and research to better understand its pathogenic potential and to develop effective treatment strategies. Overall, the clinical relevance of Staphylococcus pragensis underscores the importance of recognizing CoNS as significant pathogens in healthcare settings.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Staphylococcus pragensis is a species of bacteria that is primarily associated with human skin and mucosal surfaces, making it a notable inhabitant of the human microbiome. This organism thrives in various ecological niches, particularly in areas that are warm and moist, such as the axillary region, groin, and interdigital spaces of the feet. Its ability to adapt to these environments is facilitated by its halotolerance, allowing it to survive in conditions with varying salt concentrations, which is common in skin environments due to sweat and sebaceous secretions. In terms of ecological interactions, Staphylococcus pragensis plays a crucial role in maintaining the balance of the skin microbiota. It competes with pathogenic bacteria for resources and space, thereby acting as a natural defense mechanism against infections. This competitive exclusion is vital for skin health, as it helps to prevent the colonization of harmful microorganisms. Additionally, Staphylococcus pragensis can form biofilms, which are communities of microorganisms that adhere to surfaces. This ability enhances its survival in various environments, including medical devices and implants, where it can contribute to both beneficial and detrimental outcomes. The formation of biofilms can protect the bacteria from the host's immune response and antibiotic treatment, leading to persistent infections. Overall, the ecological niche of Staphylococcus pragensis is closely tied to human health, particularly in the context of skin integrity and microbial balance. Its adaptability to different habitats and its interactions with other microorganisms underscore its significance in the human microbiome and its potential implications in clinical settings.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Staphylococcus pragensis has shown potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This organism is known for its ability to produce antimicrobial compounds, which can be harnessed in the development of new antibiotics and preservatives. Its role in fermentation processes can also be explored for the production of bioactive metabolites that have health benefits. In the realm of waste management, Staphylococcus pragensis may contribute to biodegradation processes, helping to break down organic waste materials and reduce environmental pollution. This capability is particularly valuable in the treatment of wastewater, where the organism can assist in the degradation of harmful substances, thus improving water quality. Moreover, the enzymatic activity of Staphylococcus pragensis can be utilized in various biotechnological applications, such as the production of enzymes that are essential in food processing and other industrial sectors. These enzymes can facilitate bioconversion processes, enhancing the efficiency of production methods in industries ranging from food to textiles. Overall, the diverse capabilities of Staphylococcus pragensis in fermentation, biodegradation, and enzyme production highlight its potential as a valuable asset in multiple industrial sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openchat/openchat-7b	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	gamma	N/A	alpha	beta	beta	gamma	gamma	N/A	N/A	beta	N/A	beta	beta	alpha	alpha	beta	beta	N/A	N/A	beta	beta	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	coccus	coccus	bacillus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus

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