Streptomyces alfalfae

General Information

Streptomyces alfalfae is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most intriguing aspects of S. alfalfae is its ability to produce a wide array of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it a valuable organism in the field of biotechnology and pharmaceutical research. Streptomyces species are well-known for their complex life cycle, which includes the formation of a mycelium and spore chains, contributing to their adaptability and survival in various environments. S. alfalfae is no exception and exhibits a robust ability to thrive in soil, particularly in association with plant roots. This symbiotic relationship is of particular interest because it can enhance plant growth and health, making S. alfalfae a potential candidate for use in sustainable agriculture. Another unique feature of S. alfalfae is its genetic makeup, which harbors numerous gene clusters responsible for the biosynthesis of its diverse secondary metabolites. The exploration of these gene clusters through genomic and metagenomic approaches can lead to the discovery of novel compounds with potential therapeutic applications. In summary, Streptomyces alfalfae stands out due to its prolific production of bioactive compounds, its symbiotic relationship with plants, and its genetic potential for novel drug discovery. These characteristics make it a highly valuable organism for both scientific research and practical applications in medicine and agriculture.

Streptomyces alfalfae is a fascinating actinobacterium primarily known for its role in the soil ecosystem and its interactions with plants, particularly alfalfa. This organism is notable for its ability to produce a variety of bioactive compounds, including antibiotics and other secondary metabolites, which can have significant implications for agricultural practices and plant health. One of the most interesting aspects of S. alfalfae is its capacity to promote plant growth and enhance resistance to pathogens. The unique metabolic pathways of S. alfalfae allow it to synthesize compounds that can suppress plant diseases, making it a valuable candidate for biocontrol applications. Research has shown that this bacterium can produce antifungal agents that inhibit the growth of various phytopathogens, thereby protecting crops and improving yield. Additionally, S. alfalfae has been studied for its potential in bioremediation, as it can degrade environmental pollutants, showcasing its versatility and importance in ecological sustainability. The genetic and biochemical pathways involved in its secondary metabolite production are of great interest to researchers, as they may lead to the discovery of new drugs and agricultural products. Overall, Streptomyces alfalfae stands out not only for its beneficial effects on plant health but also for its contributions to the field of microbiology and biotechnology, making it a subject of ongoing research and exploration.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces alfalfae

NCBI ID

1642299

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/018/141/485/GCA_018141485.1_ASM1814148v1

File for sequence-based predictions:
GCA_018141485.1_ASM1814148v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces alfalfae is primarily known for its role in agriculture, particularly in the context of plant health. However, its clinical implications are less well-documented compared to other members of the Streptomyces genus. It is recognized for its ability to produce various bioactive compounds, which may have potential therapeutic applications. While Streptomyces alfalfae is not typically associated with human infections or disease in the same way as pathogenic bacteria, its metabolites could be explored for their antimicrobial properties against resistant strains. Research into the antimicrobial resistance mechanisms of Streptomyces species suggests that they may harbor genes that confer resistance to certain antibiotics, which is a significant area of concern in clinical settings. Furthermore, the potential use of Streptomyces alfalfae in probiotics or as a source of novel antibiotics could be an avenue for future studies, particularly in the context of immune response modulation. Overall, while Streptomyces alfalfae does not have a direct link to human disease, its biochemical capabilities and interactions with other microorganisms in the environment may have indirect implications for human health and disease management.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces alfalfae is a soil-dwelling bacterium primarily associated with agricultural ecosystems and grassland biomes. This microorganism thrives in nutrient-rich environments, particularly in the rhizosphere of Medicago sativa (alfalfa), where it plays a crucial role in promoting plant health and growth. Its presence is often linked to the following ecological niches and habitats: Soil Microhabitats: Streptomyces alfalfae is commonly found in the upper layers of fertile soils, where it contributes to the decomposition of organic matter. This process enriches the soil with nutrients, enhancing its fertility and supporting plant life. Symbiotic Relationships: This bacterium is known for its mutualistic interactions with plants, particularly legumes. It can enhance nitrogen availability through its ability to fix atmospheric nitrogen, which is essential for plant growth. In return, the plants provide carbohydrates and other organic compounds to the bacteria, creating a beneficial cycle. Antibiotic Production: Streptomyces alfalfae is part of the larger Streptomyces genus, known for its ability to produce a variety of antibiotics. This characteristic allows it to compete effectively with other microorganisms in the soil, helping to maintain a balanced microbial community. Adaptation to Environmental Conditions: This organism exhibits remarkable adaptability to varying soil conditions, including changes in moisture and nutrient levels. Its ability to thrive in diverse soil types makes it a key player in maintaining soil health and fertility across different agricultural landscapes. In summary, Streptomyces alfalfae is integral to the health of agricultural ecosystems, contributing to nutrient cycling, plant growth promotion, and microbial diversity within its habitat.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces alfalfae is recognized for its significant contributions to various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This actinobacterium is known for its ability to produce a range of bioactive compounds, including antibiotics, which are crucial in the development of new pharmaceuticals. Its role in fermentation processes allows for the production of these valuable metabolites, making it a key player in the pharmaceutical industry. In the realm of biotechnology, Streptomyces alfalfae is utilized for its enzymatic activities, particularly in the degradation of complex organic materials. This capability is essential in waste treatment processes, where the organism can help break down agricultural waste, thus contributing to sustainable waste management practices. The enzymes produced by this microorganism can also be harnessed for various applications, including the production of biofuels through the breakdown of lignocellulosic biomass, showcasing its potential in biofuel production. Moreover, Streptomyces alfalfae has been studied for its role in promoting plant growth and health, which can be beneficial in agriculture. By producing plant growth-promoting substances, it can enhance crop yields and reduce the need for chemical fertilizers, aligning with sustainable agricultural practices. Overall, the diverse applications of Streptomyces alfalfae highlight its importance in advancing industrial processes and promoting environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	anthropic/claude-3.5-sonnet	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	false	true	true	true	false	true	true	false	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	spirillum ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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