Mycobacterium gastri

General Information

Mycobacterium gastri is a species of bacteria within the genus Mycobacterium, which is known for its slow-growing nature. This microorganism is particularly interesting due to its unique metabolic capabilities and its potential role in environmental and clinical settings. One of the most notable characteristics of M. gastri is its ability to degrade complex organic compounds, making it valuable in bioremediation efforts. This species can break down pollutants and other harmful substances, contributing to environmental cleanup and sustainability. From a research perspective, M. gastri is also significant because it shares some genetic and phenotypic traits with pathogenic mycobacteria, such as Mycobacterium tuberculosis. This makes it a useful model organism for studying the biology and pathogenic mechanisms of more harmful relatives, without the same level of biohazard risk. Additionally, M. gastri has been studied for its unique cell wall structure, which is rich in mycolic acids. This feature not only contributes to its resilience in harsh environments but also provides insights into the development of new antibiotics and treatments for mycobacterial infections. Overall, Mycobacterium gastri stands out due to its environmental applications, its role as a model organism in medical research, and its distinctive biochemical properties.

Mycobacterium gastri is a species of the genus Mycobacterium, which is known for its unique characteristics and ecological significance. This organism is particularly interesting due to its association with the gastrointestinal tracts of various animals, including ruminants. Its ability to survive in harsh environments makes it a subject of interest for researchers studying microbial resilience and adaptation mechanisms. One of the notable features of M. gastri is its complex lipid composition, which includes mycolic acids that contribute to its distinctive cell wall structure. This unique composition not only aids in its survival but also has implications for its pathogenic potential and interactions with host immune systems. Furthermore, M. gastri has been studied for its potential role in biodegradation processes within the gut microbiome, highlighting its importance in nutrient cycling and overall gut health. Researchers are particularly keen on understanding how this organism interacts with other gut microbes and its impact on the host's metabolism. In addition, the study of M. gastri can provide insights into the evolution of mycobacterial species, especially in relation to their environmental adaptations and host associations. This makes it a valuable organism for evolutionary biology and microbiology research, as scientists seek to unravel the complexities of microbial life in diverse ecosystems.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium gastri

NCBI ID

1777

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/102/175/GCF_002102175.1_ASM210217v1

File for sequence-based predictions:
GCF_002102175.1_ASM210217v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium gastri is a member of the Mycobacterium genus, which is known for its role in various human diseases. While M. gastri is less studied compared to its more notorious relatives like Mycobacterium tuberculosis, it has been associated with certain clinical implications. Clinical relevance primarily revolves around its potential role in gastrointestinal infections and its presence in the human microbiome. It has been isolated from gastric biopsies, suggesting a possible link to gastritis or other gastric disorders. In terms of pathogenicity, M. gastri may exhibit some degree of virulence, although the mechanisms are not as well characterized as those of other pathogenic mycobacteria. Its ability to survive in harsh environments, such as the acidic conditions of the stomach, indicates potential immune evasion strategies that allow it to persist in the human body. Regarding antimicrobial resistance, there is limited data available, but like many mycobacteria, it may possess intrinsic resistance to certain antibiotics, which complicates treatment options in cases of infection. Currently, there are no established medical applications such as probiotics, vaccines, or therapeutics specifically linked to M. gastri. However, understanding its role in the microbiome could provide insights into its potential impact on human health and disease associations. Further research is needed to clarify its clinical significance and any potential implications for public health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium gastri is primarily associated with the gastrointestinal tract of various hosts, particularly in mammals. This microorganism thrives in the unique environment of the stomach and intestines, where it plays a significant role in the digestion and metabolism of complex substrates. Its presence is often linked to the breakdown of dietary components, contributing to the overall health of the host's digestive system. In terms of ecological niches, Mycobacterium gastri is adapted to the acidic conditions of the stomach, showcasing its ability to withstand low pH levels. This adaptation allows it to occupy a specific niche where few other microorganisms can survive, thus reducing competition and enabling it to flourish. Furthermore, Mycobacterium gastri may engage in symbiotic relationships with its host, aiding in nutrient absorption and possibly influencing the host's immune response. This interaction highlights its importance in maintaining a balanced microbiome within the gastrointestinal tract. Overall, the ecological role of Mycobacterium gastri in the gastrointestinal biome underscores its significance in digestive health and its potential impact on the host's overall well-being.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium gastri has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium gastri may play a role in the fermentation of biomass, converting organic materials into biofuels through fermentation processes. This capability is particularly valuable in the development of sustainable energy sources, as it can help in the conversion of agricultural waste into usable fuel. Additionally, there is potential for Mycobacterium gastri in pharmaceutical development. Its unique metabolic pathways may lead to the discovery of novel compounds that could be utilized in drug formulation. The organism's ability to produce specific metabolites can be harnessed for the development of new therapeutic agents. Overall, Mycobacterium gastri presents a promising avenue for research and application in biotechnology, waste management, biofuel production, and pharmaceutical development, with its involvement in fermentation, biodegradation, and enzyme production being particularly noteworthy.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	google/palm-2-chat-bison-32k	google/gemini-pro	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	openchat/openchat-7b	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	true	false	false	true	false	false	false	false	true	false	false	false	false	true	true	true	true	false	false	false	false	true	true	false	false
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	false	false	true	false	false	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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