Mycolicibacterium gadium

General Information

Source: gpt-4o-2024-05-13

Mycolicibacterium gadium is a fascinating microorganism belonging to the genus Mycolicibacterium, which is known for its complex and unique cell wall structure rich in mycolic acids. One of the most intriguing aspects of M. gadium is its potential application in bioremediation. This organism has shown the ability to degrade various environmental pollutants, making it a valuable candidate for cleaning up contaminated sites. Additionally, M. gadium is of interest due to its role in the study of mycobacterial diseases. While not typically pathogenic to humans, it shares many characteristics with pathogenic mycobacteria, providing a model for understanding the biology and pathogenic mechanisms of more harmful relatives like Mycobacterium tuberculosis. The metabolic versatility of M. gadium is another noteworthy feature. It can utilize a wide range of carbon sources, which is indicative of its adaptability to different environmental conditions. This metabolic flexibility is not only important for its survival in diverse habitats but also for its potential use in industrial applications, such as the production of biofuels and bioplastics. In summary, Mycolicibacterium gadium stands out due to its environmental and industrial applications, as well as its relevance in medical research. Its ability to degrade pollutants, model mycobacterial diseases, and adapt to various carbon sources makes it a microorganism of significant scientific interest.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycolicibacterium

Species: Mycolicibacterium gadium

NCBI ID

1794

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/010/728/925/GCA_010728925.1_ASM1072892v1

File for sequence-based predictions:
GCA_010728925.1_ASM1072892v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycolicibacterium gadium is a member of the genus Mycolicibacterium, which is known for its complex lipid composition and unique cell wall structure. This microorganism has been associated with various clinical implications, particularly in the context of infections and its role in human health. Clinical relevance of M. gadium includes its potential pathogenicity, as it has been isolated from clinical specimens, suggesting a possible role in opportunistic infections, especially in immunocompromised individuals. Pathogenicity is a significant concern, as M. gadium can exhibit immune evasion strategies, allowing it to persist in the host despite the immune response. This may involve the modulation of host immune pathways or the production of virulence factors that enhance its survival. Furthermore, there is growing concern regarding antimicrobial resistance among mycobacterial species, including M. gadium. Resistance to common antibiotics can complicate treatment options, making it crucial for clinicians to be aware of potential resistance mechanisms when managing infections caused by this organism. In terms of medical applications, while M. gadium is not widely recognized for therapeutic use, understanding its biology and interactions with the human body could provide insights into developing novel treatments or preventive measures against mycobacterial diseases. Overall, the clinical implications of Mycolicibacterium gadium underscore the importance of ongoing research to elucidate its role in human health and disease, particularly in the context of emerging mycobacterial infections.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycolicibacterium gadium is a species of bacteria that is primarily associated with soil environments and aquatic habitats. This microorganism thrives in nutrient-rich substrates, often found in areas with high organic matter content. Its ecological niche is characterized by the ability to degrade complex organic compounds, which plays a crucial role in nutrient cycling within these biomes. Soil Biomes: In terrestrial ecosystems, M. gadium is commonly found in forest soils and wetlands, where it contributes to the decomposition of organic materials. This bacterium is known for its ability to form symbiotic relationships with various plants, enhancing nutrient availability through its metabolic processes. By breaking down organic matter, it helps in the formation of humus, which is vital for soil fertility and structure. Aquatic Biomes: In freshwater environments, such as lakes and rivers, M. gadium can be found in sediment layers, where it plays a significant role in the breakdown of organic pollutants. Its presence in these habitats indicates a healthy ecosystem, as it aids in the detoxification of harmful substances, thus contributing to the overall health of aquatic life. Overall, Mycolicibacterium gadium is an important player in both terrestrial and aquatic biomes, facilitating nutrient cycling and supporting the health of its ecosystems through its metabolic activities and interactions with other organisms.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycolicibacterium gadium has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycolicibacterium gadium can be utilized in fermentation processes to convert biomass into biofuels. The organism's metabolic pathways allow it to efficiently process substrates, leading to the generation of bioethanol or biogas, which are sustainable energy sources. Furthermore, there is potential for Mycolicibacterium gadium in pharmaceutical development. Its unique metabolic capabilities may be harnessed for the production of bioactive compounds, which could serve as precursors for drug synthesis or as therapeutic agents themselves. The exploration of its secondary metabolites could lead to the discovery of novel pharmaceuticals. Overall, Mycolicibacterium gadium presents a versatile platform for various industrial processes, particularly in biodegradation, fermentation, and the production of valuable biochemicals, making it a significant organism in the context of sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	google/gemma-7b-it	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	google/gemini-pro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain variable ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	true	true	true	true	true	false	false	false	false	false	false	false	false	false	true	true	true	true	false	false	false	false	false	false
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	false	true	true	true	true	true	false	false	false	false	true	true	true	true	true	true	false	false	true	true	true	true
Host association	N/A	true	true	false	true	false	false	true	true	true	true	true	false	false	false	false	true	true	true	true	false	false	false	false	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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