Actinomadura montaniterrae

General Information

Actinomadura montaniterrae is a fascinating microorganism belonging to the genus Actinomadura. This species is particularly interesting due to its ability to produce a variety of bioactive compounds. These compounds have potential applications in pharmaceuticals, especially as antibiotics and anticancer agents. One of the most notable features of A. montaniterrae is its complex secondary metabolism, which allows it to synthesize unique and structurally diverse molecules. This makes it a valuable subject for natural product research and drug discovery. Researchers are particularly interested in the enzymes involved in these biosynthetic pathways, as they can provide insights into novel mechanisms of chemical synthesis. Additionally, A. montaniterrae is known for its distinctive colony morphology when cultured on various media, often forming pigmented and filamentous colonies. This characteristic can be useful for identification and differentiation from other actinomycetes. The ecological role of A. montaniterrae is also noteworthy. It is typically isolated from soil environments, where it contributes to the decomposition of organic matter and the cycling of nutrients. This ecological function underscores its importance in maintaining soil health and fertility. In summary, Actinomadura montaniterrae is a microorganism of significant interest due to its bioactive compound production, unique metabolic capabilities, and ecological contributions. Its study not only advances our understanding of microbial diversity but also holds promise for the development of new therapeutic agents.

Actinomadura montaniterrae is a fascinating species of actinobacteria that was first isolated from soil samples in mountainous regions. This organism is particularly interesting due to its ability to produce a variety of bioactive compounds, which have significant implications in pharmaceutical research. Notably, it has been shown to produce secondary metabolites with antimicrobial properties, making it a valuable candidate for the discovery of new antibiotics. The unique ecological niche from which A. montaniterrae is derived suggests that it may possess adaptations that allow it to thrive in harsh environments, potentially leading to the production of novel compounds that are not found in other actinobacteria. This adaptability is a key area of interest for researchers, as it may provide insights into the mechanisms of survival and metabolic diversity in extremophiles. Furthermore, the genomic analysis of A. montaniterrae has revealed a rich biosynthetic potential, indicating that it may be capable of synthesizing a wide range of natural products. This characteristic positions it as a promising organism for biotechnological applications, particularly in the fields of drug discovery and environmental biotechnology. The ongoing study of this microorganism could lead to breakthroughs in understanding microbial ecology and the development of new therapeutic agents.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Streptosporangiales

Family: Thermomonosporaceae

Genus: Actinomadura

Species: Actinomadura montaniterrae

NCBI ID

1803903

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/008/923/365/GCF_008923365.1_ASM892336v1

File for sequence-based predictions:
GCF_008923365.1_ASM892336v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The actinomycete species Actinomadura montaniterrae has been identified as a potential pathogen in humans, particularly in cases of soft tissue infections and pulmonary infections. This organism is notable for its ability to produce a variety of bioactive compounds, which may contribute to its pathogenicity and ability to evade the immune response. Infections caused by A. montaniterrae can be challenging to treat due to its inherent antimicrobial resistance mechanisms, which may include the production of enzymes that degrade antibiotics and alterations in cell wall permeability. Furthermore, this organism has been associated with opportunistic infections in immunocompromised patients, highlighting its clinical relevance in healthcare settings. While research is ongoing, there is potential for A. montaniterrae to be explored for its beneficial properties in probiotics or as a source of novel therapeutics, given its unique metabolic capabilities. Overall, understanding the clinical implications of Actinomadura montaniterrae is crucial for developing effective treatment strategies and managing infections associated with this organism.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Actinomadura montaniterrae is a species of actinobacteria that is primarily associated with soil ecosystems and terrestrial biomes. This microorganism thrives in arid and semi-arid environments, often found in regions with limited moisture and high mineral content. Its ecological niche is characterized by its ability to degrade complex organic materials, contributing to nutrient cycling within the soil. In these soil habitats, A. montaniterrae plays a crucial role in the decomposition of organic matter, which helps in the formation of humus and enhances soil fertility. This actinobacterium is also known for its ability to produce various bioactive compounds, which can inhibit the growth of competing microorganisms, thus establishing a competitive advantage in its environment. Furthermore, A. montaniterrae exhibits notable interactions with its surroundings, including potential symbiotic relationships with plants. It may enhance plant growth by improving nutrient availability through its metabolic activities. This interaction underscores its importance in agricultural ecosystems, where it can contribute to sustainable farming practices by promoting soil health and plant productivity. Overall, Actinomadura montaniterrae is a significant player in its native biomes, showcasing the intricate relationships between microorganisms and their environments, and highlighting the importance of microbial diversity in maintaining ecological balance.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Actinomadura montaniterrae has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for its ability to produce a range of bioactive compounds, including antibiotics. This capability is particularly valuable in the development of new pharmaceuticals, as the metabolites produced during fermentation processes can lead to the discovery of novel therapeutic agents. In the realm of waste management, Actinomadura montaniterrae has demonstrated effectiveness in biodegradation processes. It can break down complex organic materials, making it useful in the treatment of industrial waste and the remediation of contaminated environments. This biodegradation ability is crucial for reducing environmental pollution and enhancing sustainability practices. Additionally, there is potential for Actinomadura montaniterrae in biofuel production. Its metabolic pathways can be harnessed to convert biomass into biofuels through fermentation, contributing to renewable energy solutions. The efficiency of this organism in degrading lignocellulosic materials can facilitate the production of second-generation biofuels, which are derived from non-food biomass. Overall, Actinomadura montaniterrae represents a versatile microorganism with applications spanning pharmaceutical development, waste treatment, and biofuel production, showcasing its importance in advancing industrial biotechnology and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	false	true	true	true	true	true	true	true	false	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true
Animal pathogenicity	N/A	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	false	false	false	true	false	true	true	false	true	false	false	true	true	false	false	true	true	false	false	false	false	false	false
Host association	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Hemolysis	N/A	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

Back to Search