Mycolicibacterium murale

General Information

Source: gpt-4o-2024-05-13

Mycolicibacterium murale is a fascinating microorganism that belongs to the genus Mycolicibacterium, which is part of the broader family of Mycobacteriaceae. This species is particularly interesting due to its unique cell wall composition, which includes mycolic acids. These long-chain fatty acids contribute to the organism's resilience and ability to survive in harsh environments, making it a subject of interest in studies related to microbial resistance and persistence. One of the most intriguing aspects of M. murale is its potential for bioremediation. This microorganism has shown promise in breaking down complex organic compounds, including pollutants. Its ability to degrade environmental contaminants makes it a valuable candidate for cleaning up polluted sites, particularly those contaminated with hydrocarbons and other persistent organic pollutants. Additionally, Mycolicibacterium murale has been studied for its metabolic versatility. It can utilize a wide range of carbon sources, which is indicative of its adaptability to various ecological niches. This metabolic flexibility is not only interesting from a basic science perspective but also has practical implications for industrial applications, such as in the production of biofuels and bioproducts. From a phylogenetic standpoint, M. murale is closely related to other mycobacteria, yet it possesses distinct genetic markers that set it apart. These genetic differences are valuable for understanding the evolutionary pathways and diversification within the Mycobacteriaceae family. In summary, Mycolicibacterium murale is a microorganism of significant interest due to its resilience, bioremediation potential, metabolic versatility, and unique genetic characteristics. These traits make it a valuable subject for research in environmental science, industrial microbiology, and evolutionary biology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycolicibacterium

Species: Mycolicibacterium murale

NCBI ID

182220

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/025/822/305/GCF_025822305.1_ASM2582230v1

File for sequence-based predictions:
GCF_025822305.1_ASM2582230v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycolicibacterium murale is a member of the genus Mycolicibacterium, which is known for its complex lipid composition and unique cell wall structure. This microorganism has been associated with various clinical implications, particularly in the context of infections and immune response mechanisms. It has been identified in environmental samples and has potential relevance in human health, particularly in immunocompromised individuals. Pathogenicity is a significant concern, as M. murale can be involved in opportunistic infections, especially in patients with underlying conditions such as HIV/AIDS or those undergoing immunosuppressive therapy. The organism's ability to evade the immune response is attributed to its thick mycolic acid-rich cell wall, which can hinder phagocytosis by immune cells. This characteristic may contribute to its survival in hostile environments within the human body. Furthermore, there is growing concern regarding antimicrobial resistance, as some strains of Mycolicibacterium species have shown resistance to common antibiotics, complicating treatment options for infections. While M. murale is not as widely studied as other mycobacterial species, its presence in clinical samples suggests a need for further research to understand its role in human disease fully. There is also potential for exploring its use in medical applications, such as in the development of novel therapeutics or as a model organism for studying mycobacterial pathogenesis. Overall, the clinical implications of Mycolicibacterium murale highlight the importance of monitoring environmental mycobacteria and their potential impact on human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycolicibacterium murale is a species of actinobacteria that is primarily associated with urban environments and soil ecosystems. This microorganism thrives in areas where organic matter is abundant, often found in decaying plant material and compost. Its ability to degrade complex organic compounds makes it a vital player in nutrient cycling within these habitats. Urban Environments: In urban settings, Mycolicibacterium murale can be isolated from contaminated soils and wastewater treatment facilities. Here, it contributes to the breakdown of pollutants, showcasing its role in bioremediation processes. The presence of this bacterium in such environments indicates its adaptability to anthropogenic influences and its potential for environmental cleanup. Soil Ecosystems: Within soil ecosystems, Mycolicibacterium murale interacts with various soil microorganisms, forming complex microbial communities. It participates in symbiotic relationships with plants, aiding in nutrient uptake and enhancing soil health. This bacterium is particularly effective in the degradation of xenobiotic compounds, which are often found in polluted soils, thus playing a crucial role in maintaining soil quality and fertility. Overall, Mycolicibacterium murale exemplifies the importance of microorganisms in ecosystem functioning, particularly in urban and soil biomes, where they contribute to both ecological balance and environmental sustainability.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycolicibacterium murale has shown significant potential in various industrial applications. One of the primary areas of interest is in biotechnology, where Mycolicibacterium murale is utilized for its unique metabolic capabilities. This organism is known for its ability to degrade complex organic compounds, making it valuable in waste management processes. It can effectively break down pollutants in contaminated environments, contributing to bioremediation efforts. In the realm of biofuel production, Mycolicibacterium murale can be involved in fermentation processes that convert biomass into biofuels. Its metabolic pathways can be harnessed to produce bioethanol or other biofuels from agricultural waste, thus promoting sustainable energy solutions. Furthermore, the organism has potential applications in pharmaceutical development. Its unique biochemical properties may lead to the discovery of novel compounds that can be used in drug formulation or as antimicrobial agents. The enzymatic activity of Mycolicibacterium murale can also be explored for the production of specific enzymes that are useful in various industrial processes, including food processing and textile manufacturing. Overall, Mycolicibacterium murale represents a promising candidate for advancing technologies in biotechnology, waste management, biofuel production, and pharmaceutical development, showcasing its versatility and importance in modern industrial applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemma-7b-it	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	false	true	true	true	true	false	false	false	false	false	false	true	true	true	true	false	false	true	true	true	true	false	false	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	false	true	false	false	true	true	true	true	false	false	true	true	false	false	true	true	true	true	true	true	true	true	false	false	false	false
Host association	TRUE	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗

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