Proteus hauseri

General Information

Proteus hauseri is a fascinating microorganism that belongs to the family Enterobacteriaceae. This bacterium is particularly interesting due to its swarming motility, a phenomenon where the bacteria move in a coordinated manner across solid surfaces. This behavior is not only a subject of curiosity but also of significant research interest because it involves complex regulatory mechanisms and cellular differentiation. Another notable feature of Proteus hauseri is its ability to produce urease, an enzyme that hydrolyzes urea into ammonia and carbon dioxide. This enzymatic activity is crucial for the bacterium's survival in environments with high urea concentrations, such as the urinary tract, making it a model organism for studying urinary tract infections (UTIs). Proteus hauseri also exhibits a unique ability to degrade a variety of organic compounds, which has implications for bioremediation. Its metabolic versatility allows it to thrive in diverse environments, from soil to the human body, making it a valuable subject for ecological and environmental microbiology studies. In addition, Proteus hauseri is known for its antibiotic resistance mechanisms, which are of great concern in clinical settings. Understanding these mechanisms can provide insights into combating antibiotic-resistant infections, a growing global health issue. Overall, Proteus hauseri is a microorganism of significant interest due to its complex behaviors, metabolic capabilities, and clinical relevance, making it a valuable subject for a wide range of scientific research.

Proteus hauseri is a fascinating member of the Proteus genus, known for its unique biochemical properties and ecological significance. This bacterium is particularly interesting due to its ability to produce urease, an enzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide. This characteristic not only plays a crucial role in nitrogen cycling in various environments but also contributes to its pathogenic potential in human hosts, particularly in urinary tract infections. One of the standout features of P. hauseri is its versatility in nutrient utilization, allowing it to thrive in diverse habitats, including soil, water, and the gastrointestinal tracts of animals. This adaptability makes it a valuable organism for studying microbial ecology and the dynamics of microbial communities. Additionally, P. hauseri has been noted for its antimicrobial resistance, which poses challenges in clinical settings. Understanding the mechanisms behind this resistance can provide insights into the development of new therapeutic strategies and the management of antibiotic resistance in pathogenic bacteria. Furthermore, research on P. hauseri contributes to our understanding of bioenergetics and metabolic pathways, particularly in relation to its urease activity and its role in the nitrogen cycle. This makes it a significant organism for studies in environmental microbiology and biogeochemistry. In summary, Proteus hauseri stands out not only for its clinical relevance but also for its ecological importance, making it a valuable subject for ongoing research in microbiology and infectious diseases.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Gammaproteobacteria

Order: Enterobacterales

Family: Morganellaceae

Genus: Proteus

Species: Proteus hauseri

NCBI ID

183417

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/004/116/975/GCF_004116975.1_ASM411697v1

File for sequence-based predictions:
GCF_004116975.1_ASM411697v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Proteus hauseri is a member of the Enterobacteriaceae family and is known for its clinical relevance primarily in the context of urinary tract infections (UTIs). It is often isolated from patients with complicated UTIs, particularly in those with underlying conditions such as diabetes or urinary tract abnormalities. The organism exhibits pathogenicity through its ability to produce urease, which contributes to the formation of struvite stones and can lead to obstructive uropathy. In terms of antimicrobial resistance, Proteus hauseri has shown resistance to multiple classes of antibiotics, including beta-lactams and aminoglycosides, complicating treatment options for infections it causes. This resistance is often attributed to the production of extended-spectrum beta-lactamases (ESBLs), which can hydrolyze a wide range of beta-lactam antibiotics. The organism's interaction with the human body includes its ability to evade the immune response through various mechanisms, such as the production of biofilms, which protect it from phagocytosis and antibiotic action. This biofilm formation is particularly problematic in catheter-associated infections, where Proteus hauseri can persist and lead to chronic infections. While Proteus hauseri is not commonly associated with outbreaks, its role in healthcare-associated infections underscores the importance of monitoring its prevalence and resistance patterns in clinical settings. Understanding the clinical implications of Proteus hauseri is crucial for effective management and treatment of infections it may cause.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Proteus hauseri is a species of bacteria commonly found in various habitat types associated with both terrestrial and aquatic environments. This microorganism is particularly prevalent in freshwater ecosystems, where it thrives in nutrient-rich conditions such as ponds, lakes, and streams. Its ability to adapt to different environmental conditions allows it to flourish in areas with varying levels of organic matter and temperature fluctuations. In these aquatic habitats, Proteus hauseri plays a crucial role in the decomposition of organic material, contributing to nutrient cycling and the overall health of the ecosystem. It is known for its ability to break down complex organic compounds, which aids in the mineralization process, making nutrients available for other organisms in the food web. Additionally, Proteus hauseri can be found in soil environments, particularly in areas with high organic content. Here, it interacts with other soil microorganisms, contributing to the soil microbiome and enhancing soil fertility. Its presence can influence the microbial community structure, promoting symbiotic relationships with plants and other soil-dwelling organisms. Overall, Proteus hauseri is an important player in both freshwater and terrestrial biomes, showcasing its adaptability and essential role in maintaining ecological balance through its interactions with the environment.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Proteus hauseri has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. One notable application is its role in waste treatment, where Proteus hauseri can contribute to the biodegradation of organic matter, helping to reduce pollution in wastewater. This process is essential for maintaining environmental health and can be utilized in municipal and industrial wastewater treatment facilities. In the realm of biotechnology, Proteus hauseri is recognized for its ability to produce specific enzymes that can be harnessed in various industrial processes. These enzymes can facilitate fermentation processes, which are crucial in the production of biofuels and other bioproducts. The efficiency of these enzymatic reactions can lead to more sustainable production methods, reducing the reliance on fossil fuels. Furthermore, Proteus hauseri has been studied for its potential in pharmaceutical development, particularly in the synthesis of bioactive compounds. Its metabolic pathways can be exploited to produce valuable pharmaceuticals, including antibiotics and other therapeutic agents. This highlights the organism's versatility and importance in the ongoing search for new drugs and treatments. Overall, the applications of Proteus hauseri in biodegradation, enzyme production, and fermentation underscore its significance in advancing industrial processes and promoting sustainability across various sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-flash-1.5	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	openai/gpt-4o	openai/gpt-4o	mistralai/mistral-7b-instruct	openchat/openchat-7b	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	gram stain variable ✗	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Animal pathogenicity	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗
Health association	N/A	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	beta	N/A	beta	beta	beta	N/A	beta	beta	beta	gamma	gamma	N/A	N/A	N/A	N/A	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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