Streptomyces ambofaciens

General Information

Streptomyces ambofaciens is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. ambofaciens is its ability to produce antibiotics, particularly spiramycin, which is used in the treatment of bacterial infections. This makes it a valuable organism in the field of medical microbiology and pharmaceutical research. Streptomyces ambofaciens is also interesting due to its complex life cycle, which includes the formation of a mycelium and the production of spores. This life cycle is similar to that of fungi, despite Streptomyces being a bacterium, and it provides a unique model for studying differentiation and development in prokaryotes. Another unique feature of S. ambofaciens is its large genome, which is typical of the Streptomyces genus. The genome encodes a vast array of biosynthetic gene clusters, many of which are responsible for the production of bioactive compounds. This genetic richness makes S. ambofaciens a valuable resource for biotechnological applications, including the discovery of new drugs and the development of novel biocatalysts. In addition to its antibiotic production, S. ambofaciens has been studied for its role in soil ecology. It contributes to the decomposition of organic matter and the cycling of nutrients, playing a crucial role in maintaining soil health. This ecological significance, combined with its biotechnological potential, underscores the importance of S. ambofaciens in both natural and applied sciences. Overall, Streptomyces ambofaciens is a microorganism of great interest due to its antibiotic production, complex life cycle, large genome, and ecological role. Its study continues to provide valuable insights into microbial physiology, genetics, and biotechnology.

Streptomyces ambofaciens is a fascinating actinobacterium known for its remarkable ability to produce a wide array of bioactive compounds, particularly antibiotics. This species is particularly notable for its role in the production of streptomycin, one of the first antibiotics used to treat tuberculosis, which underscores its historical significance in the field of medicine. The ability of S. ambofaciens to synthesize such potent antimicrobial agents makes it a valuable organism for pharmaceutical research and development. One of the unique characteristics of S. ambofaciens is its complex life cycle, which includes the formation of filamentous structures and spores. This life cycle is not only interesting from a biological perspective but also contributes to its ecological role in soil environments, where it helps in the decomposition of organic matter and nutrient cycling. Additionally, S. ambofaciens has been studied for its potential in biocontrol applications, as it can produce compounds that inhibit the growth of plant pathogens. This property makes it a candidate for sustainable agricultural practices, providing an alternative to chemical pesticides. The genomic analysis of S. ambofaciens has revealed insights into its metabolic pathways and the genetic basis for its antibiotic production, making it a model organism for studying secondary metabolite biosynthesis. Researchers are particularly interested in the regulatory mechanisms that control the expression of antibiotic biosynthetic genes, which could lead to the discovery of new drugs and therapeutic agents. In summary, Streptomyces ambofaciens stands out not only for its historical contributions to medicine but also for its ecological importance and potential applications in agriculture and biotechnology. Its ability to produce diverse bioactive compounds continues to make it a subject of extensive research, highlighting its value in both environmental and health sciences.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces ambofaciens

NCBI ID

1889

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/632/865/GCF_001632865.1_ASM163286v1

File for sequence-based predictions:
GCF_001632865.1_ASM163286v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces ambofaciens is a filamentous bacterium known for its significant role in the production of antibiotics, particularly streptomycin, which is crucial in the treatment of tuberculosis and other bacterial infections. This organism is part of the larger genus Streptomyces, which is renowned for its ability to produce a wide array of bioactive compounds, making it a vital player in the field of pharmaceutical microbiology. In terms of pathogenicity, Streptomyces ambofaciens is generally considered non-pathogenic to humans; however, its ability to produce antibiotics has implications for antimicrobial resistance. The widespread use of antibiotics derived from this organism has led to the emergence of resistant strains of bacteria, highlighting the need for careful management of antibiotic use in clinical settings. Moreover, the organism's interaction with the human body is primarily beneficial due to its role in antibiotic production. However, there are instances where the misuse of antibiotics can disrupt the normal microbiota, leading to secondary infections or dysbiosis. In terms of immune evasion strategies, Streptomyces ambofaciens does not exhibit traditional pathogenic mechanisms, as it is not typically associated with infections in humans. Instead, its relevance lies in its contribution to the development of therapeutics and its potential use in probiotics, although this area requires further research. Overall, Streptomyces ambofaciens serves as a critical organism in the development of antibiotics, with implications for both human health and the ongoing challenge of antimicrobial resistance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces ambofaciens is a filamentous bacterium commonly found in soil and decaying organic matter, particularly in temperate and tropical regions. This microorganism thrives in nutrient-rich environments where it plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling within the ecosystem. Its ability to produce a wide array of bioactive compounds, including antibiotics, makes it a significant player in the microbial community of these habitats. In the soil biome, S. ambofaciens interacts with various other microorganisms, forming complex relationships that can include competition for resources and mutualistic interactions that enhance nutrient availability. This bacterium is particularly known for its role in the production of streptomycin, an antibiotic that not only helps it compete against other soil microbes but also has implications for agricultural practices by controlling plant pathogens. Additionally, S. ambofaciens can be found in marine environments, where it contributes to the degradation of organic materials in coastal sediments. Its adaptability to different pH levels and salinity conditions allows it to thrive in diverse ecological niches, showcasing its ecological versatility. Overall, Streptomyces ambofaciens is an essential component of its biomes, influencing both the microbial dynamics and the broader ecological processes through its metabolic activities and interactions with other organisms.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces ambofaciens is renowned for its significant contributions to various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and agriculture. This actinobacterium is primarily recognized for its role in the production of antibiotics, notably streptomycin, which is crucial in treating bacterial infections. The process of fermentation is central to its application in antibiotic production, where Streptomyces ambofaciens is cultivated in controlled environments to maximize yield. In addition to its pharmaceutical uses, Streptomyces ambofaciens has demonstrated potential in biodegradation processes, particularly in the breakdown of complex organic compounds. This capability is valuable in waste management, where the organism can be employed to remediate contaminated environments, effectively degrading pollutants and contributing to environmental sustainability. Furthermore, the enzymatic activities of Streptomyces ambofaciens are harnessed in various biotechnological applications, including the production of enzymes that can be used in food processing and textile industries. The organism's ability to produce a range of enzymes through enzyme production processes enhances its utility in these sectors. Overall, Streptomyces ambofaciens exemplifies the versatility of microorganisms in industrial applications, showcasing its importance in pharmaceutical development, waste treatment, and biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	google/gemini-pro	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	false	true	true	false	true	true	true	true	true	false	false	false	false	true	true	true	true	true	true	true	true	true	true	false	false	false	false
Host association	FALSE	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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