Kribbella antibiotica

General Information

Kribbella antibiotica is a fascinating microorganism that belongs to the genus Kribbella, which is part of the family Nocardioidaceae. This bacterium is particularly interesting due to its ability to produce antibiotics, which is reflected in its species name, antibiotica. The production of antibiotics makes this organism valuable for pharmaceutical research and biotechnology applications. One of the most notable aspects of Kribbella antibiotica is its potential in the discovery of new antimicrobial compounds. Given the increasing problem of antibiotic resistance, the exploration of novel antibiotics from unique microbial sources like K. antibiotica is of paramount importance. Researchers are keenly interested in the secondary metabolites produced by this bacterium, as these compounds could lead to the development of new drugs to combat resistant pathogens. Additionally, Kribbella antibiotica has been isolated from diverse environments, including soil and plant-associated habitats, which suggests that it has a versatile metabolic capacity. This adaptability to different ecological niches further underscores its potential in biotechnological applications, such as bioremediation and the production of industrially relevant enzymes. In summary, Kribbella antibiotica is a microorganism of significant interest due to its antibiotic-producing capabilities, its potential in the discovery of new antimicrobial agents, and its versatile metabolic properties that make it a valuable candidate for various biotechnological applications.

Kribbella antibiotica is a fascinating actinobacterium that has garnered attention due to its antibiotic-producing capabilities. Isolated from soil samples, this microorganism is part of the rich diversity of the genus Kribbella, which is known for its ability to synthesize various bioactive compounds. The unique metabolic pathways of K. antibiotica allow it to produce a range of secondary metabolites, making it a valuable organism for pharmaceutical research and biotechnology. One of the most intriguing aspects of K. antibiotica is its potential in the development of new antibiotics. With the rise of antibiotic resistance, the search for novel antimicrobial agents is more critical than ever. K. antibiotica has shown promise in preliminary studies, indicating that it may produce compounds effective against resistant strains of bacteria. This positions it as a key player in the ongoing battle against infectious diseases. Additionally, the ecological role of K. antibiotica in soil environments is noteworthy. As a soil-dwelling organism, it contributes to the nutrient cycling and biodegradation processes, which are essential for maintaining healthy ecosystems. Its ability to thrive in diverse soil conditions also makes it an interesting subject for studies on microbial ecology and environmental sustainability. In summary, Kribbella antibiotica stands out not only for its antibiotic production but also for its ecological significance, making it a promising candidate for further research in both medical and environmental sciences.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Propionibacteriales

Family: Kribbellaceae

Genus: Kribbella

Species: Kribbella antibiotica

NCBI ID

190195

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/004/349/055/GCF_004349055.1_ASM434905v1

File for sequence-based predictions:
GCF_004349055.1_ASM434905v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Kribbella antibiotica is a notable member of the Actinobacteria phylum, primarily recognized for its antibiotic-producing capabilities. This organism has been isolated from various environmental sources, including soil, and is of particular interest due to its potential applications in antimicrobial therapy. Its ability to produce bioactive compounds positions it as a candidate for the development of new antibiotics, especially in the context of rising antimicrobial resistance among pathogenic bacteria. In terms of human health, Kribbella antibiotica has not been directly associated with human infections or diseases, which suggests that it may not be a primary pathogen. However, its role in the microbiome and potential as a probiotic is an area of ongoing research. The organism's metabolites could contribute to the modulation of the immune response, potentially offering benefits in maintaining gut health or preventing infections. Furthermore, the study of Kribbella antibiotica contributes to our understanding of microbial ecology and the interactions between microorganisms and their hosts. Its mechanisms of immune evasion and survival in competitive environments are of interest, particularly in the context of developing new therapeutic strategies against resistant pathogens. Overall, while Kribbella antibiotica is not currently linked to specific outbreaks or infections, its antibiotic production and potential role in probiotic applications highlight its relevance in the field of microbiology and medicine.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Kribbella antibiotica is a bacterium that is primarily associated with soil environments and marine ecosystems. This microorganism thrives in nutrient-rich substrates, often found in areas with high organic matter content. Its ecological niche is characterized by its ability to degrade complex organic compounds, which plays a crucial role in nutrient cycling within these biomes. Soil Biomes: In terrestrial ecosystems, Kribbella antibiotica is commonly isolated from agricultural soils and forest soils. It contributes to soil health by participating in the decomposition of organic materials, thus enhancing soil fertility. The bacterium's ability to produce antibiotics allows it to compete effectively with other soil microorganisms, which can help suppress certain plant pathogens, thereby promoting plant health and growth. Marine Environments: In marine ecosystems, Kribbella antibiotica has been found in sediments and biofilms associated with various substrates. Its presence in these environments indicates its role in the degradation of organic matter and potential contributions to the marine nutrient cycle. The bacterium may also engage in symbiotic relationships with marine organisms, aiding in their health and resilience against pathogens. Overall, Kribbella antibiotica exemplifies the intricate interactions within its biomes, showcasing its importance in both terrestrial and aquatic ecosystems through its roles in decomposition, nutrient cycling, and potential biocontrol of pathogens.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Kribbella antibiotica has shown significant potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This actinobacterium is known for its ability to produce a range of bioactive compounds, including antibiotics, which can be harnessed in the development of new medications. The production of these antibiotics typically involves fermentation, where Kribbella antibiotica is cultured under specific conditions to maximize yield and potency of the desired compounds. In addition to its pharmaceutical applications, Kribbella antibiotica has demonstrated capabilities in waste management. It can be utilized in biodegradation processes, where it helps break down complex organic materials, thus contributing to the treatment of waste and the reduction of environmental pollutants. This property is particularly valuable in the context of bioremediation, where the organism can be employed to clean up contaminated sites. Furthermore, the enzymatic activities of Kribbella antibiotica can be explored for biofuel production. By utilizing its metabolic pathways, researchers are investigating how this microorganism can assist in the conversion of biomass into biofuels, thereby promoting sustainable energy solutions. Overall, the diverse applications of Kribbella antibiotica in these industries highlight its importance as a valuable resource in modern biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-pro	google/gemini-flash-1.5	google/gemini-pro-1.5	google/gemma-7b-it	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	false	true	true	true	false	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	false	false
Animal pathogenicity	N/A	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	true	false	true	true	false	true	false	false	true	true	false	false	false	false	true	true	false	false	false	false	true	true	true	true	false	false
Host association	FALSE	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	false ✗	true ✓	false ✗	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Hemolysis	N/A	N/A	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus

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