Streptomyces cyaneus

General Information

Streptomyces cyaneus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. cyaneus is its ability to produce a variety of antibiotics, making it a valuable organism in medical and pharmaceutical research. These antibiotics include compounds that are effective against a range of bacterial pathogens, contributing to its importance in the development of new antimicrobial agents. Streptomyces cyaneus is also interesting due to its complex life cycle, which includes the formation of a mycelium and the production of spores. This life cycle is similar to that of fungi, despite Streptomyces being a genus of bacteria. The organism's ability to produce a blue pigment, from which it derives its name ('cyaneus' meaning 'blue' in Latin), is another unique feature that can be used as a phenotypic marker in laboratory settings. From a biotechnological perspective, S. cyaneus is valuable not only for its antibiotic production but also for its potential in bioremediation. The organism has been studied for its ability to degrade various environmental pollutants, including aromatic compounds, which highlights its potential use in cleaning up contaminated environments. In summary, Streptomyces cyaneus is a microorganism of significant interest due to its antibiotic production, unique life cycle, pigment production, and potential applications in bioremediation.**

Streptomyces cyaneus is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, including antibiotics and antifungal agents. This organism is particularly interesting due to its extensive secondary metabolite production, which has made it a subject of extensive research in the field of natural product chemistry. The unique metabolic pathways of S. cyaneus allow it to synthesize compounds that can inhibit the growth of various pathogens, making it a valuable resource in the search for new therapeutic agents. One of the standout features of S. cyaneus is its ability to produce cyclic peptides, which have shown potential in pharmaceutical applications. These compounds are not only effective against bacteria but also exhibit activity against fungi and even some cancer cell lines. The genetic and biochemical pathways involved in the biosynthesis of these metabolites are of great interest to researchers, as they may provide insights into the development of novel drugs. Additionally, S. cyaneus is known for its robustness in various environmental conditions, which allows it to thrive in diverse habitats, including soil and decaying organic matter. This adaptability contributes to its ecological role in nutrient cycling and soil health. The organism's ability to degrade complex organic materials also positions it as a potential candidate for bioremediation efforts, where it could be utilized to break down pollutants in contaminated environments. Overall, Streptomyces cyaneus stands out not only for its biotechnological potential but also for its ecological significance, making it a key player in both natural ecosystems and the pharmaceutical industry.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces cyaneus

NCBI ID

1904

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/004/028/635/GCF_004028635.1_ASM402863v1

File for sequence-based predictions:
GCF_004028635.1_ASM402863v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces cyaneus is a filamentous bacterium known for its significant role in the production of various bioactive compounds, particularly antibiotics. It is part of the larger genus Streptomyces, which is renowned for its ability to produce over two-thirds of the naturally derived antibiotics used in clinical settings. The clinical implications of Streptomyces cyaneus are primarily associated with its antimicrobial properties, which have been harnessed in the development of therapeutic agents against a range of bacterial infections. In terms of pathogenicity, Streptomyces cyaneus is generally considered non-pathogenic to humans; however, its close relatives within the Streptomyces genus can occasionally be implicated in opportunistic infections, particularly in immunocompromised individuals. The organism's ability to produce secondary metabolites contributes to its ecological niche, allowing it to compete effectively in various environments, including soil and decaying organic matter. Moreover, the potential for antimicrobial resistance is a critical area of study, as the overuse of antibiotics derived from Streptomyces species can lead to the emergence of resistant strains. Understanding the mechanisms of resistance in these organisms is essential for developing new therapeutic strategies and ensuring the efficacy of existing antibiotics. In addition to its role in antibiotic production, Streptomyces cyaneus has been explored for its potential applications in probiotics and bioremediation, showcasing its versatility in both health and environmental contexts. Its interactions with the human microbiome and potential benefits in promoting gut health are areas of ongoing research, although more studies are needed to establish definitive clinical applications. Overall, while Streptomyces cyaneus is not directly associated with human disease, its contributions to antibiotic production and the broader implications of its relatives in clinical microbiology underscore its importance in the field of medicine.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces cyaneus is a species of actinobacteria commonly found in soil ecosystems and decaying organic matter. This microorganism thrives in a variety of terrestrial biomes, particularly in nutrient-rich environments where organic decomposition occurs. Its presence is often associated with tropical and subtropical regions, where the warm and moist conditions favor microbial activity and growth. In these soil habitats, Streptomyces cyaneus plays a crucial role in the breakdown of complex organic materials, contributing to nutrient cycling and soil health. It is known for its ability to produce a wide range of bioactive compounds, including antibiotics, which can inhibit the growth of competing microorganisms. This characteristic not only aids in its survival but also highlights its importance in microbial interactions within the soil community. Furthermore, Streptomyces cyaneus exhibits notable symbiotic relationships with plants, where it can enhance plant growth by promoting nutrient availability and providing protection against pathogens. This interaction underscores its role as a beneficial microorganism in agricultural ecosystems, where it can be utilized for sustainable farming practices. Overall, the ecological niche of Streptomyces cyaneus is characterized by its adaptability to various soil types and its significant contributions to biogeochemical cycles, making it an essential component of the ecosystems it inhabits.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces cyaneus is renowned for its diverse industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is a prolific producer of various bioactive compounds, including antibiotics, which are crucial in the pharmaceutical industry. For instance, it has been documented to produce antibiotics such as streptomycin, which is vital for treating bacterial infections. In the realm of biotechnology, Streptomyces cyaneus is utilized in the fermentation process to synthesize these valuable metabolites. The organism's ability to thrive in various environments makes it an excellent candidate for bioprocessing applications, where it can be harnessed to produce enzymes that facilitate biochemical reactions. Moreover, Streptomyces cyaneus plays a significant role in waste management through its capacity for biodegradation. It can break down complex organic materials, making it useful in the treatment of agricultural and industrial waste. This biodegradation capability is particularly important in the context of environmental sustainability, as it helps in the reduction of waste and the recycling of nutrients back into the ecosystem. In summary, Streptomyces cyaneus demonstrates a multifaceted potential in various industries, particularly through its roles in fermentation, enzyme production, and biodegradation, making it a valuable organism in the pursuit of innovative solutions in biotechnology and environmental management.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	mistralai/mistral-7b-instruct	google/gemini-flash-1.5	google/gemini-flash-1.5	google/palm-2-chat-bison-32k	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	false	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	false	false	true	true	true	true	true	true	false	true	false	false	false	false	false	false	true	true	true	true	true	true	false	false
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	N/A	false	false	false	false	false	false	false	true	false	false	false	false	true	true	false	false	true	true	false	false	false	false	false	false	false	false
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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