Streptomyces glaucescens

General Information

Streptomyces glaucescens is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most noteworthy characteristics of S. glaucescens is its ability to produce the antibiotic tetracycline, a broad-spectrum antibiotic that has been extensively used in medical treatments. This makes S. glaucescens particularly valuable in pharmaceutical research and biotechnology. Another unique feature of S. glaucescens is its complex life cycle, which includes the formation of a mycelium and the production of spores. This life cycle is similar to that of fungi, despite S. glaucescens being a bacterium, and it contributes to its ability to thrive in various environments, including soil. From a research perspective, S. glaucescens is also interesting due to its genetic and metabolic diversity. The organism's genome harbors numerous gene clusters responsible for the biosynthesis of various bioactive compounds. This genetic potential makes it a subject of intense study for the discovery of new antibiotics and other therapeutic agents. In addition to its medical applications, S. glaucescens plays a significant role in ecological processes. It contributes to the decomposition of organic matter in soil, thereby participating in nutrient cycling and soil health maintenance. This ecological role underscores its importance beyond just its antibiotic-producing capabilities. Overall, Streptomyces glaucescens stands out as a multifaceted organism with significant implications for medicine, biotechnology, and ecology, making it a valuable subject of ongoing scientific research.

Streptomyces glaucescens is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, particularly antibiotics. This organism is part of the larger genus Streptomyces, which is renowned for its role in natural product biosynthesis. One of the most notable features of S. glaucescens is its production of the antibiotic glaucomycin, which has shown efficacy against certain bacterial pathogens, making it a subject of interest in pharmaceutical research. The ecological role of S. glaucescens is also significant; it is commonly found in soil and decaying organic matter, contributing to the decomposition process and nutrient cycling. This ability to thrive in diverse environments highlights its adaptability and potential for biotechnological applications. Moreover, the genetic and metabolic pathways of S. glaucescens are of great interest to researchers studying secondary metabolite production. The organism's genome contains numerous gene clusters that are believed to be involved in the synthesis of various natural products, which could lead to the discovery of new drugs. In summary, Streptomyces glaucescens stands out not only for its antibiotic production but also for its ecological importance and potential in biotechnological innovations, making it a valuable organism for ongoing research in microbiology and pharmacology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces glaucescens

NCBI ID

1907

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/761/215/GCA_000761215.1_ASM76121v1

File for sequence-based predictions:
GCA_000761215.1_ASM76121v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces glaucescens is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This species has been studied for its potential in antimicrobial resistance and its ability to produce various secondary metabolites that can be beneficial in clinical settings. One of the notable aspects of Streptomyces glaucescens is its production of the antibiotic glaucomycin, which has shown effectiveness against certain bacterial infections, highlighting its potential as a therapeutic agent in the fight against pathogenic bacteria. In terms of human health, Streptomyces glaucescens is not typically associated with human disease; however, its metabolites may have implications in the development of new antibiotics to combat resistant strains of bacteria. The organism's ability to produce a wide range of bioactive compounds makes it a subject of interest in pharmaceutical research. Furthermore, the interaction of Streptomyces glaucescens with the human microbiome is an area of ongoing research, particularly in understanding how its metabolites can influence immune responses and overall health. While there are no documented outbreaks or infections directly linked to Streptomyces glaucescens, its role in the production of antimicrobial agents positions it as a valuable organism in the context of public health and disease prevention. Overall, Streptomyces glaucescens exemplifies the dual nature of microorganisms, serving as both a potential source of therapeutic agents and a subject of study in the context of antimicrobial resistance and human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces glaucescens is a filamentous bacterium commonly found in soil and decaying organic matter, particularly in temperate regions. This microorganism thrives in nutrient-rich environments where it plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling within the ecosystem. Its ability to produce a variety of bioactive compounds makes it significant in the soil microbiome, where it interacts with other microorganisms and plants, often promoting plant growth through the production of growth-promoting substances and enhancing soil fertility. In addition to its role in nutrient cycling, Streptomyces glaucescens is known for its antibiotic production, which helps in suppressing the growth of competing microbial species, thus maintaining a balanced microbial community. This characteristic is particularly important in agricultural ecosystems, where it can help control plant pathogens and reduce the need for chemical pesticides. Furthermore, Streptomyces glaucescens exhibits symbiotic relationships with various plants, aiding in their health and resilience against environmental stressors. Its adaptability to different soil types and moisture levels allows it to thrive in diverse habitats, from forest floors to grasslands, making it a vital component of these ecosystems. Overall, the ecological niche of Streptomyces glaucescens is characterized by its contributions to soil health, plant growth promotion, and its role in the intricate web of interactions within the soil ecosystem.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces glaucescens is renowned for its significant contributions to various industrial applications. One of the most notable areas is in pharmaceutical development, where S. glaucescens is known to produce a range of bioactive compounds, including antibiotics. These compounds are crucial in the fight against bacterial infections and have been utilized in the development of new therapeutic agents. The organism's ability to undergo fermentation processes allows for the efficient production of these valuable metabolites. In addition to its pharmaceutical applications, Streptomyces glaucescens plays a role in biotechnology through its enzymatic activities. It produces enzymes that can be harnessed for various biotechnological processes, including the breakdown of complex organic materials, which is essential in waste management and biodegradation efforts. This capability makes it a candidate for use in the treatment of waste materials, where it can help in the degradation of pollutants and organic waste, thus contributing to environmental sustainability. Furthermore, S. glaucescens has potential in the field of biofuel production. Its metabolic pathways can be exploited to convert biomass into biofuels through fermentation processes, providing a renewable energy source. The organism's efficiency in degrading lignocellulosic materials positions it as a valuable asset in the development of sustainable biofuel technologies. Overall, Streptomyces glaucescens exemplifies the versatility of microbial applications across multiple industries, particularly in pharmaceuticals, biotechnology, waste management, and biofuels, showcasing its importance in both health and environmental sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	mistralai/mistral-7b-instruct	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	true	false	true	true	true	false	true	true	false	false	false	false	false	false	false	false	true	true	true	true	false	false	true	true	true	true	true	true
Biofilm formation	N/A	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	false	true	false	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true
Host association	FALSE	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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