Streptomyces rochei

General Information

Streptomyces rochei is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. rochei is its ability to produce a variety of antibiotics, including the well-known antifungal agent, candicidin. This makes it a valuable organism in the field of pharmaceutical research and biotechnology. Another intriguing aspect of S. rochei is its complex life cycle, which includes the formation of a mycelium and the production of spores. This life cycle is not only interesting from a biological standpoint but also has practical implications for the cultivation and harvesting of its bioactive compounds. Moreover, S. rochei has been studied for its potential in bioremediation. Its ability to degrade various organic compounds suggests that it could be used to clean up environmental pollutants, making it an organism of interest for environmental science. In addition to its antibiotic production and bioremediation potential, S. rochei is also a subject of genetic research. The organism's genome has been sequenced, providing insights into the genetic basis of its secondary metabolite production and other unique traits. This genetic information is invaluable for scientists looking to engineer S. rochei or related organisms for enhanced production of useful compounds. Overall, Streptomyces rochei stands out due to its antibiotic production, complex life cycle, bioremediation potential, and genetic research applications. These characteristics make it a highly valuable and interesting organism in various fields of scientific research.

Streptomyces rochei is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, including antibiotics and other secondary metabolites. This organism is particularly interesting due to its role in natural product discovery, as it has been a source of several clinically relevant antibiotics, contributing significantly to the pharmaceutical industry. The unique metabolic pathways of S. rochei allow it to synthesize complex molecules that are often difficult to replicate synthetically. One of the standout features of S. rochei is its ability to thrive in diverse environments, which enhances its potential for biotechnological applications. Researchers are particularly interested in its genetic and biochemical pathways, as they can provide insights into the mechanisms of antibiotic resistance and the development of new antimicrobial agents. The genomic analysis of S. rochei has revealed a rich repertoire of biosynthetic gene clusters, making it a prime candidate for studies aimed at discovering novel compounds. Additionally, S. rochei has been studied for its potential in bioremediation, as it can degrade various environmental pollutants. This capability not only highlights its ecological importance but also opens avenues for its application in environmental biotechnology. The organism's versatility in producing diverse metabolites and its ecological roles make it a valuable subject for ongoing research in microbiology and pharmacology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces rochei

NCBI ID

1928

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/030/863/865/GCF_030863865.1_ASM3086386v1

File for sequence-based predictions:
GCF_030863865.1_ASM3086386v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces rochei is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. While S. rochei itself is not commonly associated with human infections, it is relevant in the context of antimicrobial resistance and the development of novel therapeutics. Clinical implications of S. rochei include its potential use in the production of antibiotics such as streptomycin, which has been historically important in treating tuberculosis and other bacterial infections. Moreover, the ability of S. rochei to produce various secondary metabolites makes it a subject of interest in pharmaceutical research, particularly in the search for new drugs to combat resistant strains of bacteria. The organism's interaction with the human microbiome is also noteworthy, as it may contribute to the overall health of the gut flora, although specific studies on its probiotic potential are limited. In terms of immune evasion strategies, S. rochei does not exhibit pathogenic behavior in humans, but its relatives in the Streptomyces genus have been studied for their mechanisms of biofilm formation and antibiotic production, which can influence microbial communities and resistance patterns. Overall, while S. rochei is not a primary pathogen, its contributions to antibiotic production and potential applications in medicine underscore its relevance in the field of microbiology and infectious disease management.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces rochei is a species of actinobacteria commonly found in soil and decaying organic matter. This microorganism thrives in a variety of terrestrial biomes, particularly in temperate forests and tropical regions, where it plays a crucial role in nutrient cycling and organic matter decomposition. Its ability to degrade complex organic compounds makes it an essential player in the soil ecosystem, contributing to soil health and fertility. In its natural habitat, Streptomyces rochei engages in symbiotic relationships with plants, promoting plant growth by enhancing nutrient availability. This interaction is particularly significant in agricultural settings, where it can help improve crop yields by facilitating the uptake of essential nutrients such as nitrogen and phosphorus. Additionally, Streptomyces rochei is known for its production of various antibiotics and bioactive compounds, which can inhibit the growth of competing microorganisms. This characteristic not only aids in its survival but also contributes to the overall microbial diversity and stability of the soil microbiome. Overall, Streptomyces rochei exemplifies the intricate relationships within terrestrial ecosystems, showcasing its adaptability and vital role in maintaining ecological balance.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces rochei is renowned for its significant contributions to various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This actinobacterium is a prolific producer of bioactive compounds, including antibiotics, which are crucial in the fight against bacterial infections. For instance, Streptomyces rochei has been documented to produce the antibiotic rocheamine, showcasing its potential in pharmaceutical development. In addition to its role in antibiotic production, Streptomyces rochei is also involved in biodegradation processes. It can degrade complex organic compounds, making it valuable in waste management applications. This capability allows it to be utilized in the treatment of contaminated soils and wastewater, where it helps in breaking down pollutants and restoring environmental health. Furthermore, Streptomyces rochei has been explored for its potential in biofuel production. Its enzymatic activity can facilitate the breakdown of lignocellulosic biomass, which is a critical step in the conversion of plant materials into fermentable sugars for bioethanol production. This process underscores its importance in the development of sustainable energy sources. Overall, Streptomyces rochei exemplifies a versatile microorganism with applications spanning from fermentation processes to enzyme production, making it a valuable asset in various industrial sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	google/palm-2-chat-bison-32k	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemma-7b-it	google/gemma-7b-it	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain variable ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	false	true	true	true	true	true	true	true	true	true	false	false	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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