Streptomyces tendae

General Information

Streptomyces tendae is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most noteworthy characteristics of S. tendae is its ability to produce a variety of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it a valuable organism in the field of biotechnology and pharmaceutical research. Streptomyces tendae is particularly interesting due to its production of the antibiotic tetracycline, which has been widely used in medicine to treat bacterial infections. Additionally, it produces nikkomycins, which are antifungal agents that inhibit chitin synthase, an enzyme crucial for fungal cell wall synthesis. This dual capability of producing both antibacterial and antifungal compounds highlights the organism's potential in developing new therapeutic agents. Another unique feature of S. tendae is its complex life cycle, which includes the formation of a mycelium and the production of spores. This life cycle is similar to that of fungi, despite S. tendae being a bacterium, and it contributes to its ability to thrive in various environments, including soil. The mycelial growth allows for extensive colonization and interaction with other microorganisms, which can lead to the discovery of novel compounds through microbial interactions. From a genetic perspective, Streptomyces tendae has a large genome that encodes numerous biosynthetic gene clusters. These clusters are responsible for the synthesis of its diverse array of secondary metabolites. The study of these gene clusters can provide insights into the biosynthetic pathways and regulatory mechanisms that control the production of bioactive compounds, offering opportunities for genetic manipulation and optimization of metabolite production. In summary, Streptomyces tendae is a highly valuable organism in scientific research due to its ability to produce a wide range of bioactive compounds, its complex life cycle, and its genetic potential for biosynthetic diversity. Its contributions to antibiotic and antifungal development underscore its importance in both basic and applied microbiological research.

Streptomyces tendae is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, making it a valuable organism in pharmaceutical research. This species is particularly notable for its role in the natural production of antibiotics, including the well-studied compound tendae mycin, which exhibits significant antibacterial properties. The ability of S. tendae to synthesize these compounds highlights its potential as a source for new drug discovery, especially in the face of rising antibiotic resistance. In addition to its antibiotic production, S. tendae is also recognized for its capacity to degrade complex organic materials, which positions it as a potential agent in bioremediation efforts. This characteristic not only underscores its ecological importance but also opens avenues for research into sustainable waste management practices. Furthermore, S. tendae serves as a model organism for studying the genetics and biochemistry of secondary metabolite production in actinobacteria. Its well-characterized genome provides insights into the biosynthetic pathways that lead to the formation of various natural products, making it a key player in the field of microbial biotechnology. Overall, Streptomyces tendae stands out as a significant organism in both environmental and pharmaceutical research, with its unique capabilities offering promising prospects for future studies.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces tendae

NCBI ID

1932

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/008/632/955/GCF_008632955.1_ASM863295v1

File for sequence-based predictions:
GCF_008632955.1_ASM863295v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces tendae is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This actinobacterium has been studied for its potential in antimicrobial resistance due to its ability to produce various secondary metabolites that can inhibit the growth of pathogenic bacteria. One of the notable clinical implications of Streptomyces tendae is its production of the antibiotic tetracycline, which has been widely used in treating bacterial infections. In terms of pathogenicity, Streptomyces tendae is generally considered non-pathogenic to humans; however, its close relatives within the Streptomyces genus can sometimes be associated with opportunistic infections, particularly in immunocompromised individuals. The organism's ability to produce a wide range of enzymes and metabolites may also play a role in immune evasion strategies, although specific mechanisms related to Streptomyces tendae have not been extensively documented. Furthermore, the potential use of Streptomyces tendae in probiotics and therapeutics is an area of ongoing research, as its metabolites may have beneficial effects on human health, including anti-inflammatory properties. Overall, while Streptomyces tendae is primarily recognized for its contributions to antibiotic production, its interactions with human health and disease, particularly in the context of antimicrobial resistance and potential therapeutic applications, remain significant areas of interest.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces tendae is a species of bacterium that thrives primarily in soil ecosystems, particularly in nutrient-rich environments. This microorganism is commonly found in terrestrial biomes where it plays a crucial role in the decomposition of organic matter. Its ability to produce a variety of bioactive compounds makes it significant in the soil microbiome, contributing to nutrient cycling and soil health. Ecological Niches: - _Streptomyces tendae occupies a niche as a decomposer, breaking down complex organic materials such as plant debris and dead organisms. This process not only recycles nutrients back into the soil but also enhances soil structure and fertility. - It is also known for its role in antibiotic production, which helps in suppressing the growth of pathogenic microorganisms, thus maintaining a balanced microbial community in the soil. Habitats: - This bacterium is typically found in agricultural soils, where it can thrive in the presence of organic fertilizers and crop residues. Its presence is often associated with healthy soil ecosystems that support diverse plant life. - Streptomyces tendae can also be isolated from compost heaps, where it contributes to the breakdown of organic materials, further enriching the compost with beneficial microorganisms. Interactions with Surroundings: - The interactions of Streptomyces tendae with other soil microorganisms can lead to symbiotic relationships, enhancing the overall health of the soil microbiome. For instance, it may engage in mutualistic interactions with fungi, aiding in nutrient exchange and improving plant growth. - Its ability to produce secondary metabolites allows it to compete effectively with other soil microbes, thus playing a vital role in the microbial community dynamics. In summary, Streptomyces tendae is an essential component of soil ecosystems, contributing to nutrient cycling, soil health, and the suppression of pathogens, making it a key player in maintaining ecological balance.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces tendae is renowned for its diverse industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is a prolific producer of various bioactive compounds, including antibiotics, which are crucial in the pharmaceutical industry. For instance, it has been documented to produce antibiotics such as tendae mycin, which can be utilized in treating bacterial infections, showcasing its role in pharmaceutical development. In the realm of biotechnology, Streptomyces tendae is involved in the production of enzymes that can be harnessed for various applications, including the degradation of complex organic materials. This enzymatic activity is particularly valuable in biodegradation processes, where the organism can help break down pollutants and organic waste, contributing to effective waste management strategies. Moreover, Streptomyces tendae has potential in the production of biofuels through the fermentation of biomass. The organism's ability to degrade lignocellulosic materials can facilitate the conversion of agricultural waste into fermentable sugars, which can then be transformed into bioethanol, thus supporting sustainable energy solutions. Overall, Streptomyces tendae exemplifies a versatile microorganism with significant contributions to biotechnology, waste management, and biofuel production, primarily through its roles in fermentation, enzyme production, and biodegradation.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	anthropic/claude-3-haiku:beta	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/gemma-7b-it	google/gemma-7b-it	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	false	true	true	false	true	true	false	false	true	true	true	true	true	true	false	false	true	true	true	true	true	true	false	false	false	false
Host association	FALSE	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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