Streptomyces aureus

General Information

Streptomyces aureus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. aureus is its ability to produce a wide array of antibiotics, making it a valuable subject of study in pharmaceutical research. These antibiotics are crucial in the fight against various bacterial infections, and the discovery of new compounds from S. aureus could lead to the development of novel treatments. Another interesting aspect of S. aureus is its complex life cycle, which includes the formation of mycelium and spores. This life cycle is not only intriguing from a biological standpoint but also has practical implications for the cultivation and harvesting of the organism for industrial purposes. Moreover, Streptomyces species, including S. aureus, are known for their ability to degrade a variety of organic materials, contributing to soil health and nutrient cycling. This makes them important players in natural ecosystems and potential candidates for bioremediation efforts. In summary, Streptomyces aureus stands out due to its antibiotic production capabilities, complex life cycle, and ecological significance. These attributes make it a valuable organism for both scientific research and practical applications in medicine and environmental management.

Streptomyces aureus is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, including antibiotics. This organism is part of the larger genus Streptomyces, which is renowned for its role in natural product biosynthesis. One of the most interesting aspects of S. aureus is its capacity to synthesize golden yellow pigments, which not only contribute to its distinctive appearance but also have potential applications in biotechnology and medicine. The secondary metabolites produced by S. aureus include antimicrobial agents that are effective against a range of pathogenic bacteria and fungi. This makes it a valuable organism for research in the field of drug discovery, particularly in the search for new antibiotics to combat antibiotic-resistant strains of bacteria. The genetic and metabolic pathways involved in the production of these compounds are of significant interest, as they can provide insights into the mechanisms of natural product biosynthesis. Additionally, S. aureus has been studied for its role in soil ecology, where it contributes to the decomposition of organic matter and the cycling of nutrients. Its ability to thrive in various environments makes it a model organism for understanding microbial interactions in complex ecosystems. The potential for biotechnological applications, such as bioremediation and the production of valuable metabolites, further enhances the significance of Streptomyces aureus in both environmental and pharmaceutical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces aureus

NCBI ID

193461

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/725/495/GCA_000725495.1_Doro.v1.0

File for sequence-based predictions:
GCA_000725495.1_Doro.v1.0_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces aureus is a filamentous bacterium known for its significant role in the production of antibiotics, particularly in the context of human health. It is part of the larger genus Streptomyces, which is renowned for its ability to produce a wide array of bioactive compounds. One of the most notable clinical implications of Streptomyces aureus is its potential in the development of antimicrobial agents, which can be utilized in treating various bacterial infections. However, it is essential to note that while Streptomyces aureus itself is not typically associated with pathogenicity in humans, its close relatives can be. The genus is often studied for its antimicrobial resistance mechanisms, which can provide insights into how bacteria evade treatment. Understanding these mechanisms is crucial, especially in the face of rising antibiotic resistance globally. In terms of immune evasion strategies, Streptomyces aureus does not directly interact with the human immune system as a pathogen would, but its metabolites can influence microbial communities in the human microbiome, potentially affecting immune responses indirectly. Moreover, the use of Streptomyces aureus in probiotics and therapeutics is an area of ongoing research, as its metabolites may have beneficial effects on human health, including anti-inflammatory properties. Overall, while Streptomyces aureus is not a primary pathogen, its contributions to antibiotic production and potential therapeutic applications underscore its relevance in clinical microbiology.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces aureus is a filamentous bacterium commonly found in soil ecosystems and decaying organic matter. This microorganism thrives in nutrient-rich environments, particularly in areas with high organic content, such as forest floors and agricultural fields. Its ability to decompose complex organic materials makes it a vital player in nutrient cycling within these biomes. In the soil biome, S. aureus contributes to the breakdown of organic matter, releasing essential nutrients back into the soil, which supports plant growth. This process is crucial for maintaining soil health and fertility. Additionally, S. aureus is known for its role in antibiotic production, which helps it compete with other microorganisms in its habitat, showcasing its importance in microbial community dynamics. Furthermore, S. aureus can engage in symbiotic relationships with plants, promoting plant health through the production of growth-promoting substances. This interaction not only benefits the plants but also enhances the overall biodiversity of the ecosystem. Overall, Streptomyces aureus is an essential component of terrestrial biomes, playing a significant role in decomposition, nutrient cycling, and plant-microbe interactions, which are fundamental to ecosystem stability and productivity.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces aureus is renowned for its significant contributions to various industrial applications. One of the most notable areas is in pharmaceutical development, where Streptomyces aureus is known for its ability to produce a range of bioactive compounds, including antibiotics. This organism is particularly famous for its role in the production of antibiotics through the fermentation process, which allows for the extraction of valuable metabolites that can combat bacterial infections. In addition to its pharmaceutical uses, Streptomyces aureus has potential in biotechnology. It is utilized in the production of enzymes that can be harnessed for various industrial processes, including the breakdown of complex organic materials. This enzymatic activity is crucial in applications such as biodegradation, where the organism helps in the decomposition of organic waste, thereby contributing to waste management efforts. Furthermore, Streptomyces aureus has been explored for its capabilities in biofuel production. The organism can be involved in the fermentation of biomass, converting it into biofuels like ethanol, which presents a sustainable alternative to fossil fuels. This process not only aids in energy production but also promotes the recycling of waste materials. Overall, Streptomyces aureus exemplifies the versatility of microorganisms in industrial applications, particularly in the fields of pharmaceuticals, biotechnology, waste management, and biofuels, showcasing its importance in modern industry.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	google/gemini-pro	google/gemma-7b-it	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	true	false	false	false	true	false	false	false	false	false	false	false	false	true	true	true	true	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	true	true	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	N/A	true	true	true	true	true	true	true	true	true	false	false	false	false	true	true	true	true	true	true	false	false	false	false	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	coccus ✗	coccus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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