Streptomyces viridochromogenes

General Information

Streptomyces viridochromogenes is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most noteworthy characteristics of S. viridochromogenes is its ability to produce the antibiotic phosphinothricin (also known as glufosinate), which is a potent inhibitor of glutamine synthetase. This compound has significant agricultural applications as a herbicide, making S. viridochromogenes highly valuable in the field of biotechnology and agronomy. Another intriguing aspect of S. viridochromogenes is its complex life cycle, which includes the formation of a mycelium and the production of spores. This life cycle is typical of the Streptomyces genus and contributes to its ability to thrive in diverse environments, including soil. The organism's ability to degrade a wide range of organic materials also makes it an important player in soil ecology and nutrient cycling. From a research perspective, S. viridochromogenes is of great interest due to its genetic and metabolic diversity. The genome of S. viridochromogenes harbors numerous gene clusters responsible for the biosynthesis of various secondary metabolites, many of which have potential pharmaceutical applications. The study of these gene clusters can lead to the discovery of new drugs and bioactive compounds. In summary, Streptomyces viridochromogenes is a microorganism of significant interest due to its antibiotic production, complex life cycle, and genetic potential for the discovery of new bioactive compounds. Its contributions to agriculture, soil ecology, and pharmaceutical research underscore its importance in multiple scientific domains.

Streptomyces viridochromogenes is a fascinating actinobacterium known for its remarkable ability to produce a wide array of bioactive compounds, particularly antibiotics. This organism is part of the genus Streptomyces, which is renowned for its role in natural product biosynthesis. One of the most notable features of S. viridochromogenes is its production of viridochromogen, a pigment that imparts a greenish hue to the colonies, which is not only visually striking but also indicative of its metabolic capabilities. This microorganism has garnered significant interest in the field of pharmaceutical research due to its potential in discovering new antimicrobial agents. The secondary metabolites produced by S. viridochromogenes have shown efficacy against various pathogens, making it a valuable candidate for the development of novel antibiotics in an era where antibiotic resistance is a growing concern. Additionally, S. viridochromogenes is known for its ability to degrade complex organic compounds, which positions it as a potential player in bioremediation efforts. Its enzymatic pathways allow it to break down pollutants, contributing to environmental sustainability. The genetic and metabolic pathways of S. viridochromogenes are also of great interest to researchers. The organism's genome has been sequenced, providing insights into the biosynthetic gene clusters responsible for its diverse array of metabolites. This genomic information can facilitate the engineering of strains for enhanced production of desired compounds, further amplifying its value in biotechnological applications. In summary, Streptomyces viridochromogenes stands out not only for its striking pigmentation but also for its significant contributions to antibiotic discovery and environmental applications, making it a key organism in microbiological and biotechnological research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces viridochromogenes

NCBI ID

1938

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/156/055/GCF_002156055.1_ASM215605v1

File for sequence-based predictions:
GCF_002156055.1_ASM215605v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces viridochromogenes is a filamentous bacterium known for its significant role in the production of various bioactive compounds, particularly antibiotics. It is primarily recognized for its ability to produce antimicrobial agents, which have been utilized in the treatment of various bacterial infections. This organism is particularly notable for its production of viridochromes, which are pigments that may have potential applications in the field of antimicrobial therapy. In terms of pathogenicity, S. viridochromogenes is generally considered non-pathogenic to humans; however, its close relatives within the genus Streptomyces can be associated with opportunistic infections, especially in immunocompromised individuals. The organism's ability to produce a wide range of secondary metabolites makes it a subject of interest in pharmaceutical research, particularly in the search for new antibiotics to combat antimicrobial resistance. Moreover, S. viridochromogenes has been studied for its potential use in bioremediation, as it can degrade various environmental pollutants, which indirectly contributes to human health by improving environmental conditions. Its role in the human microbiome is less well-documented, but the presence of such organisms in soil and plant-associated environments suggests a potential for beneficial interactions. Overall, while Streptomyces viridochromogenes is not directly associated with human disease, its contributions to antibiotic production and bioremediation highlight its importance in both clinical and environmental contexts.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces viridochromogenes is a soil-dwelling bacterium that thrives in a variety of terrestrial ecosystems. This microorganism is predominantly found in nutrient-rich soils, where it plays a crucial role in the decomposition of organic matter. Its ability to produce a wide range of bioactive compounds makes it an important player in the soil microbiome, contributing to nutrient cycling and soil health. In its natural habitat, S. viridochromogenes engages in antibiotic production, which helps it compete with other microorganisms for resources. This competitive advantage allows it to establish itself in microbial communities and contributes to the overall biodiversity of the soil environment. The organism is also known for its ability to form spores, enabling it to survive in harsh conditions and remain dormant until favorable conditions arise. Additionally, S. viridochromogenes has been documented to have symbiotic relationships with various plants, promoting plant growth through the production of growth-promoting substances. This interaction highlights its role in agricultural ecosystems, where it can enhance soil fertility and plant health. Overall, Streptomyces viridochromogenes is a vital component of soil ecosystems, contributing to ecological balance, nutrient cycling, and plant-microbe interactions.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces viridochromogenes is renowned for its diverse industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and agriculture. This actinobacterium is a prolific producer of various bioactive compounds, including antibiotics, which are crucial in the fight against bacterial infections. Its ability to synthesize these compounds makes it a valuable resource in the pharmaceutical industry, where it contributes to the development of new antimicrobial agents. In addition to its pharmaceutical significance, Streptomyces viridochromogenes plays a role in biodegradation processes. It has been documented to effectively degrade complex organic pollutants, making it useful in waste management applications. This capability allows it to be employed in the treatment of contaminated soils and wastewater, where it helps in the breakdown of harmful substances, thus contributing to environmental sustainability. Furthermore, this microorganism is involved in biofuel production through its metabolic pathways that can be harnessed for the conversion of biomass into biofuels. The enzymatic activities of Streptomyces viridochromogenes facilitate the fermentation of organic materials, leading to the generation of bioethanol and other biofuels, which are essential for reducing reliance on fossil fuels. Overall, Streptomyces viridochromogenes exemplifies the potential of microorganisms in various industrial sectors, showcasing its importance in biotechnology, waste management, and sustainable energy solutions.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	google/gemini-pro	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	TRUE	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	true	true	true	false	true	true	false	false	false	false	true	true	true	true	false	false	true	true	true	true	true	true	false	false	true	true
Host association	FALSE	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	spirillum ✗	spirillum ✗	bacillus ✗	bacillus ✗

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