Streptomyces halstedii

General Information

Streptomyces halstedii is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. halstedii is its ability to produce antibiotics, making it a valuable organism in pharmaceutical research and biotechnology. This species is particularly interesting due to its production of antifungal compounds, which have potential applications in agriculture for controlling plant pathogens. Streptomyces halstedii forms a complex mycelial network, which is a hallmark of the Streptomyces genus. This network allows the organism to efficiently explore and colonize its environment, often found in soil. The mycelium can differentiate into spores, which are crucial for its survival and dissemination in various habitats. Another unique feature of S. halstedii is its production of pigments, which can vary in color and are often used as a visual marker in laboratory settings. These pigments are secondary metabolites that may also have bioactive properties, contributing to the organism's ecological interactions and potential utility in various applications. From a genetic perspective, Streptomyces halstedii has a large and complex genome, which encodes a vast array of biosynthetic gene clusters. These clusters are responsible for the synthesis of its diverse secondary metabolites, including antibiotics, antifungals, and pigments. The study of these gene clusters provides insights into the molecular mechanisms of natural product biosynthesis and offers opportunities for the discovery of new bioactive compounds. In summary, Streptomyces halstedii is a microorganism of significant interest due to its antibiotic production, complex mycelial structure, pigment production, and extensive biosynthetic capabilities. Its contributions to natural product discovery and potential applications in medicine and agriculture make it a valuable subject of ongoing research.

Streptomyces halstedii is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, making it a valuable organism in pharmaceutical research. This species is particularly interesting due to its role in the natural production of antibiotics and other secondary metabolites that have significant therapeutic potential. The unique metabolic pathways of S. halstedii allow it to synthesize compounds that can inhibit the growth of various pathogenic microorganisms, which is crucial in the ongoing search for new antibiotics in the face of rising antibiotic resistance. One of the standout features of S. halstedii is its ability to thrive in diverse environments, which contributes to its genetic diversity and the potential for discovering novel compounds. This adaptability not only enhances its survival but also increases the likelihood of uncovering new bioactive substances that could lead to the development of innovative treatments for infectious diseases. Additionally, S. halstedii has been studied for its role in soil health and plant growth promotion, as it can produce compounds that stimulate plant growth and enhance resistance to pathogens. This dual role in both human health and agriculture underscores its importance in biotechnological applications. Research into S. halstedii continues to reveal its potential as a source of new drugs and as a beneficial organism in sustainable agricultural practices.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces halstedii

NCBI ID

1944

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/019/219/635/GCA_019219635.1_ASM1921963v1

File for sequence-based predictions:
GCA_019219635.1_ASM1921963v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces halstedii is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. While S. halstedii itself is not primarily associated with human disease, it has been studied for its potential applications in antimicrobial therapy due to its ability to produce various secondary metabolites. Clinical implications of this organism include its potential use in the development of new antibiotics to combat antimicrobial resistance in pathogenic bacteria. In the context of human health, S. halstedii has been investigated for its role in soil and plant health, which indirectly affects human health through the food chain. Its interactions with plants can influence the microbiome of crops, potentially impacting food safety and nutrition. Furthermore, the organism's ability to produce compounds with antifungal and antibacterial properties makes it a candidate for biotechnological applications, including the development of probiotics or therapeutics aimed at enhancing human health. While there are no well-documented outbreaks or infections directly linked to S. halstedii, its study contributes to the broader understanding of the Streptomyces genus and its implications in disease prevention and treatment strategies. Overall, the clinical relevance of Streptomyces halstedii lies in its potential contributions to pharmaceutical development and its role in maintaining ecological balance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces halstedii is a soil-dwelling bacterium that thrives in a variety of terrestrial ecosystems, particularly in agricultural soils and decaying organic matter. This microorganism is commonly found in environments rich in organic material, where it plays a crucial role in the decomposition process. Its ability to break down complex organic compounds contributes to nutrient cycling, making it an essential player in maintaining soil health and fertility. Ecological Niches: In its natural habitat, Streptomyces halstedii occupies a unique ecological niche as a decomposer. It is particularly adept at degrading plant materials, which helps in the recycling of nutrients back into the soil. This process not only supports plant growth but also enhances soil structure and aeration. Interactions with Surroundings: This bacterium is known for its antibiotic production, which can inhibit the growth of competing microorganisms. This characteristic allows Streptomyces halstedii to establish itself in nutrient-rich environments where competition is high. Additionally, it may engage in symbiotic relationships with plants, promoting plant health through the production of growth-promoting substances. Environmental Adaptation: S. halstedii exhibits remarkable adaptability to varying soil conditions, including changes in moisture and nutrient availability. Its resilience allows it to thrive in both disturbed and undisturbed soils, making it a vital component of agricultural ecosystems where it can help manage soil health and plant productivity. Overall, Streptomyces halstedii is a key organism in the soil biome, contributing to ecological balance and sustainability.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces halstedii has shown significant potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This actinobacterium is known for its ability to produce a wide range of bioactive compounds, including antibiotics, which are crucial in the pharmaceutical industry. Its role in fermentation processes allows for the production of these valuable metabolites, making it a key player in the development of new antimicrobial agents. In the realm of waste management, Streptomyces halstedii has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property can be harnessed for the treatment of agricultural waste and other organic pollutants, contributing to more sustainable waste management practices. Moreover, the enzymatic activities of Streptomyces halstedii are noteworthy, as they can be utilized in various biotechnological applications. The enzymes produced by this microorganism can facilitate enzyme production processes that are essential in industries such as food processing and biofuel production. For instance, the ability to degrade cellulose and lignin positions Streptomyces halstedii as a potential candidate for biofuel production through the conversion of biomass into fermentable sugars. Overall, Streptomyces halstedii stands out as a versatile microorganism with promising applications across multiple industries, particularly in the development of sustainable practices and innovative products.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	google/gemma-7b-it	google/gemini-flash-1.5	google/gemini-flash-1.5	google/palm-2-chat-bison-32k	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain negative ✗	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	N/A	true	true	true	true	false	false	false	true	true	true	true	true	true	true	false	false	false	false	false	false	true	true	true	true	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	false	false	true	false	false	false	true	true	true	true	false	false	false	false	true	true	true	true	false	false	true	true	false	false
Host association	FALSE	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Spore formation	TRUE	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	alpha	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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