Streptomyces rubrogriseus

General Information

Streptomyces rubrogriseus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. rubrogriseus is its ability to produce a variety of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it a valuable organism in pharmaceutical research and biotechnology. The genus Streptomyces is well-known for its complex life cycle and the formation of mycelium, which is a network of filamentous cells. S. rubrogriseus exhibits this characteristic, forming a dense, branched mycelium that can be observed under a microscope. Another intriguing aspect of S. rubrogriseus is its pigmentation. The species name 'rubrogriseus' hints at its distinctive red and gray coloration, which is due to the production of specific pigments. These pigments not only contribute to the organism's unique appearance but also have potential applications in the development of natural dyes and colorants. From a genomic perspective, S. rubrogriseus has a large and complex genome, typical of the Streptomyces genus. This genetic richness underpins its ability to synthesize a wide array of secondary metabolites. Researchers are particularly interested in the biosynthetic gene clusters present in S. rubrogriseus, as these clusters hold the genetic blueprints for the production of its diverse bioactive compounds. In summary, Streptomyces rubrogriseus is a microorganism of significant interest due to its prolific production of bioactive compounds, unique pigmentation, and complex genomic architecture. Its potential applications in medicine, biotechnology, and industry make it a valuable subject of ongoing research.

Streptomyces rubrogriseus is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, making it a valuable organism in pharmaceutical research. This species is particularly noted for its production of antibiotics, which are crucial in the fight against bacterial infections. The secondary metabolites produced by S. rubrogriseus include rubrogrisin, a compound that has shown potential in exhibiting antimicrobial properties against various pathogens. One of the unique aspects of S. rubrogriseus is its ability to thrive in diverse environments, often isolated from soil samples, which highlights its ecological versatility. This adaptability not only contributes to its survival but also enhances its potential for bioprospecting, where researchers seek new natural products for drug development. Additionally, the genomic studies of S. rubrogriseus have revealed a rich biosynthetic capacity, indicating that this organism may produce even more undiscovered compounds. The genetic pathways responsible for the synthesis of these metabolites are of great interest, as they can provide insights into the mechanisms of natural product biosynthesis and lead to the discovery of novel drugs. Furthermore, the study of S. rubrogriseus contributes to our understanding of microbial ecology and the role of actinobacteria in soil health and nutrient cycling. Its interactions with other microorganisms and its impact on the soil microbiome are areas ripe for exploration, potentially leading to advancements in agricultural practices and sustainable farming. In summary, Streptomyces rubrogriseus stands out not only for its antibiotic production but also for its ecological significance and potential in biotechnological applications, making it a key player in both environmental and medical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces rubrogriseus

NCBI ID

194673

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/003/112/595/GCF_003112595.1_ASM311259v1

File for sequence-based predictions:
GCF_003112595.1_ASM311259v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces rubrogriseus is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This microorganism has been studied for its potential in antimicrobial therapy, particularly due to its ability to produce various secondary metabolites that exhibit antibacterial and antifungal properties. Clinical implications of S. rubrogriseus include its potential use in the development of new therapeutics against resistant strains of bacteria, which is increasingly important in the context of rising antimicrobial resistance. In addition to its therapeutic applications, S. rubrogriseus has been implicated in certain infections, particularly in immunocompromised patients. While it is not a common pathogen, there have been isolated cases where it has been associated with opportunistic infections, highlighting the need for awareness of its potential pathogenicity in vulnerable populations. Furthermore, the organism's ability to evade the immune response is an area of interest, as it may possess mechanisms that allow it to survive in hostile environments, such as those found in human hosts. This aspect is crucial for understanding its role in disease associations and the development of effective treatment strategies. Overall, Streptomyces rubrogriseus represents a dual aspect of clinical relevance: as a source of valuable antibiotics and as a potential pathogen in specific clinical contexts. Ongoing research into its properties and interactions with the human body continues to shed light on its significance in both health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces rubrogriseus is a filamentous bacterium commonly found in soil and decaying organic matter, particularly in terrestrial ecosystems. This microorganism thrives in nutrient-rich environments where it plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling and soil health. Its ability to produce a variety of bioactive compounds makes it significant in the soil microbiome, where it interacts with other microorganisms and plants, often promoting plant growth through mechanisms such as antibiotic production and mycorrhizal associations. In addition to its role in nutrient cycling, S. rubrogriseus is known for its symbiotic relationships with various plants, enhancing their resistance to pathogens and improving nutrient uptake. This bacterium is particularly adept at adapting to varying pH levels and moisture conditions, allowing it to colonize diverse habitats ranging from arid soils to humid forest floors. Overall, Streptomyces rubrogriseus is an essential component of the terrestrial biome, contributing to ecological balance and supporting the health of its environment through its multifaceted interactions and adaptations.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces rubrogriseus is renowned for its significant contributions to various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is a prolific producer of bioactive compounds, including antibiotics, which are crucial in the pharmaceutical industry. For instance, it has been documented to produce antibiotics such as streptomycin, which is vital for treating bacterial infections. The processes involved in this production often utilize fermentation, where the organism is cultivated in controlled environments to maximize yield. In the realm of biotechnology, Streptomyces rubrogriseus is also explored for its ability to produce various enzymes that can be harnessed for industrial purposes. These enzymes can facilitate biodegradation of complex organic materials, making the organism valuable in waste management applications. By breaking down pollutants and organic waste, it contributes to the development of sustainable waste treatment solutions. Moreover, the potential of Streptomyces rubrogriseus in biofuel production is being investigated, particularly in the context of converting biomass into usable energy. The enzymatic activities of this microorganism can enhance the efficiency of biomass conversion processes, leading to more effective biofuel generation. Overall, Streptomyces rubrogriseus exemplifies the versatility of microorganisms in industrial applications, showcasing its importance in pharmaceutical development, biotechnology, and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemma-7b-it	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	true	true	true	true	true	true	true	false	false	false	false	false	false	true	true	false	false	false	false	false	false	true	true	false	false	false	false
Host association	FALSE	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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