Streptomyces brasiliensis

General Information

Streptomyces brasiliensis is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. brasiliensis is its ability to produce a wide array of antibiotics and other bioactive compounds. This makes it a valuable organism in the field of biotechnology and pharmaceutical research. Streptomyces species are known for their complex life cycle, which includes the formation of a mycelium and spore chains, contributing to their unique colony morphology. The production of geosmin by S. brasiliensis is particularly interesting, as this compound is responsible for the earthy smell of soil. This characteristic not only highlights the organism's ecological role but also its potential applications in flavor and fragrance industries. Moreover, S. brasiliensis has been studied for its potential in bioremediation due to its ability to degrade various environmental pollutants. Its enzymatic repertoire includes a variety of hydrolases, oxidoreductases, and lyases, which are instrumental in breaking down complex organic compounds. This makes S. brasiliensis a promising candidate for cleaning up contaminated environments. In summary, Streptomyces brasiliensis stands out due to its antibiotic production, unique earthy aroma, and potential in environmental applications, making it a microorganism of significant interest in multiple scientific and industrial fields.

Streptomyces brasiliensis is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, particularly antibiotics. This organism is part of the larger genus Streptomyces, which is renowned for its prolific secondary metabolite production, making it a significant player in pharmaceutical research and development. One of the most notable features of S. brasiliensis is its production of brasiliensin, a potent antibiotic that has shown effectiveness against various pathogenic bacteria. This characteristic not only highlights its potential as a source of new antimicrobial agents but also underscores the importance of soil-dwelling actinobacteria in the ongoing battle against antibiotic resistance. Additionally, S. brasiliensis is of interest due to its ability to degrade complex organic compounds, which positions it as a potential candidate for bioremediation applications. Its metabolic versatility allows it to thrive in diverse environments, contributing to nutrient cycling and soil health. The genomic analysis of S. brasiliensis has revealed a rich repertoire of biosynthetic gene clusters, suggesting that this organism may produce even more undiscovered compounds with therapeutic potential. This makes it a valuable subject for biotechnological research aimed at harnessing its capabilities for drug discovery and environmental applications. In summary, Streptomyces brasiliensis stands out not only for its antibiotic production but also for its ecological role and potential in biotechnological innovations, making it a significant organism in microbiological and pharmaceutical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces brasiliensis

NCBI ID

1954

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/014/647/875/GCA_014647875.1_ASM1464787v1

File for sequence-based predictions:
GCA_014647875.1_ASM1464787v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces brasiliensis is a filamentous bacterium known for its significant role in the production of antibiotics, particularly streptomycin. This organism is primarily found in soil and is part of the natural microbiota, contributing to the antimicrobial resistance landscape due to its ability to produce various bioactive compounds. In clinical settings, S. brasiliensis has been associated with opportunistic infections, particularly in immunocompromised patients. These infections can manifest as cutaneous lesions or systemic infections, highlighting its pathogenic potential. One of the notable aspects of S. brasiliensis is its ability to evade the immune response through the production of enzymes that degrade host immune factors, allowing it to persist in the host. Furthermore, the organism's genetic adaptability contributes to its antimicrobial resistance mechanisms, complicating treatment options for infections it may cause. In terms of medical applications, while S. brasiliensis is primarily recognized for its antibiotic production, its role in the development of probiotics and potential therapeutic agents is an area of ongoing research. Understanding the interactions of S. brasiliensis with the human microbiome may lead to novel applications in enhancing human health and combating antibiotic resistance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces brasiliensis is a filamentous bacterium commonly found in soil and decaying organic matter, particularly in tropical and subtropical regions. This microorganism thrives in nutrient-rich environments where it plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling within the ecosystem. Its ability to produce a wide array of bioactive compounds makes it significant in the soil microbiome, where it interacts with other microorganisms and plants, often promoting plant growth through the production of growth-promoting substances and enhancing soil fertility. In addition to its ecological role, Streptomyces brasiliensis is known for its antibiotic production, which helps in suppressing the growth of competing bacteria, thus allowing it to establish itself in its habitat. This competitive advantage is particularly important in microbial communities where resources are limited. Furthermore, it can form symbiotic relationships with plants, aiding in their health and resilience against pathogens. Overall, Streptomyces brasiliensis is an essential component of the terrestrial biome, contributing to both the health of the soil ecosystem and the broader ecological interactions within its environment.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces brasiliensis is renowned for its significant contributions to various industrial applications. One of the most notable areas is in pharmaceutical development, where Streptomyces brasiliensis is known for its ability to produce a range of bioactive compounds, including antibiotics such as brasiliensin. These compounds are crucial in the fight against bacterial infections and have been extensively studied for their therapeutic potential. In the realm of biotechnology, Streptomyces brasiliensis plays a vital role in fermentation processes, where it can be utilized to produce valuable metabolites. This includes the production of enzymes that can be harnessed for various industrial purposes, such as in the food industry for the breakdown of complex carbohydrates. Additionally, Streptomyces brasiliensis has demonstrated potential in waste management through its ability to degrade complex organic materials. This capability is particularly useful in biodegradation processes, where the organism can help in the breakdown of pollutants and contribute to environmental cleanup efforts. Moreover, the enzymatic activities of Streptomyces brasiliensis are being explored for their applications in biofuel production. The organism's enzymes can facilitate the conversion of biomass into fermentable sugars, which can then be transformed into biofuels, thus supporting sustainable energy initiatives. Overall, Streptomyces brasiliensis showcases a diverse range of applications across multiple industries, making it a valuable microorganism in both research and practical applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/gemma-7b-it	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	false	true	false	true	false	false	true	true	true	false	false	false	false	false	false	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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