Streptomyces kanamyceticus

General Information

Streptomyces kanamyceticus is a fascinating microorganism primarily known for its role in the production of the antibiotic kanamycin. This species belongs to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites, many of which have significant pharmaceutical applications. One of the most noteworthy characteristics of S. kanamyceticus is its ability to synthesize kanamycin, an aminoglycoside antibiotic that is effective against a broad spectrum of bacteria, including many Gram-negative and Gram-positive pathogens. This makes S. kanamyceticus particularly valuable in the field of medicine and pharmaceuticals. In addition to its antibiotic production, S. kanamyceticus exhibits a complex life cycle that includes the formation of mycelium and spores, which is typical of the Streptomyces genus. This complex differentiation process is of great interest to researchers studying bacterial development and gene regulation. Moreover, the genome of S. kanamyceticus has been sequenced, providing insights into the genetic basis for its antibiotic production and other metabolic capabilities. This genomic information is a valuable resource for biotechnological applications, including the engineering of new antibiotics and the study of resistance mechanisms. Overall, Streptomyces kanamyceticus is a remarkable organism due to its antibiotic production, complex life cycle, and genetic potential, making it a significant subject of study in microbiology and biotechnology.

Streptomyces kanamyceticus is a notable species within the genus Streptomyces, renowned for its ability to produce the antibiotic kanamycin. This organism is particularly interesting due to its role in the pharmaceutical industry, where kanamycin is utilized to treat various bacterial infections, especially those caused by Mycobacterium tuberculosis. Kanamycin is a critical drug in the treatment of multidrug-resistant tuberculosis, making S. kanamyceticus invaluable in the fight against this global health challenge. The production of kanamycin by S. kanamyceticus is a complex process that involves intricate metabolic pathways, which researchers study to enhance antibiotic production and discover new compounds. The genetic and biochemical mechanisms underlying kanamycin biosynthesis are of significant interest, as they may lead to the development of novel antibiotics or improved strains with higher yields. Additionally, S. kanamyceticus serves as a model organism for studying secondary metabolite production in actinobacteria. Its genome has been sequenced, providing insights into the genetic basis of its antibiotic production capabilities. This genomic information allows researchers to explore gene clusters responsible for the biosynthesis of kanamycin and other potential bioactive compounds. Furthermore, the ecological role of S. kanamyceticus in soil environments contributes to its uniqueness. As a soil-dwelling bacterium, it plays a crucial role in nutrient cycling and the degradation of organic matter, which is essential for maintaining soil health. Understanding its ecological interactions can provide valuable insights into microbial ecology and the development of sustainable agricultural practices. Overall, Streptomyces kanamyceticus stands out not only for its antibiotic production but also for its contributions to both medical and ecological research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces kanamyceticus

NCBI ID

1967

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/008/704/495/GCF_008704495.1_ASM870449v1

File for sequence-based predictions:
GCF_008704495.1_ASM870449v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces kanamyceticus is primarily known for its role in the production of the antibiotic kanamycin, which is effective against a variety of Gram-negative and some Gram-positive bacteria. This antibiotic is particularly significant in the treatment of tuberculosis and other serious infections caused by resistant bacteria. The clinical implications of S. kanamyceticus extend beyond its therapeutic applications; it also raises concerns regarding antimicrobial resistance. Overuse and misuse of kanamycin have led to the emergence of resistant strains, complicating treatment options for infections. In terms of its interaction with the human body, S. kanamyceticus can be associated with adverse effects related to kanamycin use, including nephrotoxicity and ototoxicity, which necessitate careful monitoring during treatment. The organism's ability to produce various secondary metabolites also suggests potential for further medical applications, including the development of new antibiotics or therapeutic agents. While S. kanamyceticus is not typically associated with infections in humans, its role in antibiotic production makes it a significant player in the ongoing battle against bacterial pathogens. Understanding its mechanisms of action and resistance is crucial for developing effective treatment strategies and mitigating the impact of antibiotic resistance in clinical settings.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces kanamyceticus is a soil-dwelling bacterium that thrives in a variety of terrestrial ecosystems, particularly in nutrient-rich soils found in temperate and tropical regions. This microorganism is commonly associated with the rhizosphere, where it plays a crucial role in promoting plant health through its ability to produce antibiotics and other bioactive compounds. Its presence in the soil contributes to the overall microbial diversity and enhances soil fertility by participating in the decomposition of organic matter and nutrient cycling. In addition to its role in soil health, Streptomyces kanamyceticus is known for its symbiotic relationships with various plants, where it can help in biocontrol of plant pathogens. This interaction not only aids in plant growth but also supports the stability of the ecosystem by reducing the reliance on chemical pesticides. Furthermore, this bacterium is often found in decaying organic matter, where it contributes to the breakdown of complex organic compounds, thus facilitating nutrient availability for other organisms in the biome. Its ability to adapt to varying environmental conditions, such as changes in moisture and nutrient levels, allows it to thrive in diverse habitats, making it a vital component of the soil microbiome. Overall, Streptomyces kanamyceticus exemplifies the intricate relationships within terrestrial biomes, showcasing its importance in maintaining ecological balance and supporting plant life through its various interactions and adaptations.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces kanamyceticus is renowned for its significant contributions to various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This organism is best known for its role in the production of the antibiotic kanamycin, which is crucial in treating bacterial infections, especially those caused by resistant strains. The process of fermentation is central to its application, where S. kanamyceticus is cultivated in controlled environments to maximize the yield of kanamycin through the fermentation of specific substrates. In addition to its pharmaceutical uses, S. kanamyceticus has potential applications in waste management. Its ability to degrade complex organic compounds makes it a candidate for biodegradation processes, where it can help in the breakdown of pollutants in contaminated environments. This capability is particularly valuable in bioremediation efforts, where the goal is to restore polluted sites by utilizing microorganisms to detoxify hazardous substances. Furthermore, the enzymatic activities of S. kanamyceticus can be harnessed for biotechnology applications, including the production of enzymes that can be used in various industrial processes, such as food processing and textile manufacturing. The organism's ability to produce a range of secondary metabolites also opens avenues for the development of new bioactive compounds, which can be explored for their potential in biofuel production and other sustainable practices. Overall, Streptomyces kanamyceticus exemplifies the versatility of actinobacteria in industrial applications, particularly through its roles in fermentation, biodegradation, and enzyme production, making it a valuable organism in both pharmaceutical and environmental sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	google/gemini-pro-1.5	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	google/gemma-7b-it	google/gemma-7b-it	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	false	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	true	true	false	true	true	true	false	true	true	true	true	true	false	false	false	false	true	true	true	true	false	false	false	false
Host association	N/A	true	true	false	true	true	true	true	true	false	true	false	false	false	false	false	false	false	false	true	true	false	false	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	coccus ✗	coccus ✗

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