Staphylococcus cornubiensis

General Information

Staphylococcus cornubiensis is a relatively newly identified species within the genus Staphylococcus. This organism is particularly interesting due to its unique genetic profile and distinctive phenotypic characteristics that set it apart from other members of the Staphylococcus genus. One of the most notable features of S. cornubiensis is its antibiotic resistance profile. This species has shown resistance to several commonly used antibiotics, which makes it a subject of significant interest in the study of antimicrobial resistance. Understanding the mechanisms behind its resistance can provide valuable insights into combating antibiotic-resistant infections. Additionally, S. cornubiensis has been isolated from various clinical samples, indicating its potential role in human infections. This makes it a valuable organism for studying pathogenesis and host-microbe interactions. Researchers are particularly interested in how this species interacts with the human immune system and its potential to cause disease. From a genetic standpoint, S. cornubiensis possesses several unique genes that are not found in other Staphylococcus species. These genes may be involved in its survival and virulence, making it a prime candidate for genomic studies aimed at understanding bacterial evolution and adaptation. In summary, Staphylococcus cornubiensis is a fascinating organism due to its antibiotic resistance, clinical relevance, and unique genetic makeup. Its study can contribute significantly to our understanding of microbial resistance, pathogenesis, and the evolutionary dynamics of bacteria.

Staphylococcus cornubiensis is a coagulase-negative staphylococcus that was first isolated from human skin. This organism is particularly interesting due to its potential role in human health and its unique ecological niche. It is part of the normal skin flora, which means it contributes to the maintenance of skin health and acts as a barrier against pathogenic microorganisms. Its presence on the skin can help prevent infections by outcompeting harmful bacteria for resources and space. One of the unique aspects of S. cornubiensis is its ability to produce bioactive compounds that may have antimicrobial properties. This characteristic makes it a valuable subject for research in the field of microbiology, particularly in the development of new antimicrobial agents. Understanding the mechanisms behind these compounds could lead to innovative treatments for infections caused by antibiotic-resistant bacteria. Additionally, S. cornubiensis has been studied for its genetic diversity and adaptability, which can provide insights into the evolution of staphylococci and their interactions with human hosts. Its genetic makeup may reveal information about resistance mechanisms and virulence factors, contributing to our understanding of how certain strains can become pathogenic. Overall, Staphylococcus cornubiensis serves as an important model organism for studying the dynamics of skin microbiota, the development of antimicrobial strategies, and the evolutionary biology of staphylococci, making it a valuable asset in both clinical and research settings.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Bacilli

Order: Bacillales

Family: Staphylococcaceae

Genus: Staphylococcus

Species: Staphylococcus cornubiensis

NCBI ID

1986155

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/183/575/GCA_900183575.1_SAMEA104055222

File for sequence-based predictions:
GCA_900183575.1_SAMEA104055222_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Staphylococcus cornubiensis is a coagulase-negative staphylococcus (CNS) that has been associated with various clinical implications, particularly in immunocompromised patients. It is known to be part of the normal skin flora but can act as an opportunistic pathogen, leading to infections such as bacteremia, endocarditis, and skin infections. Clinical relevance is heightened in patients with indwelling medical devices, where it can form biofilms, complicating treatment and leading to persistent infections. One of the significant concerns regarding Staphylococcus cornubiensis is its potential for antimicrobial resistance. Like many CNS, it can exhibit resistance to multiple antibiotics, including methicillin, which poses challenges in treatment options. The presence of resistance genes can lead to difficult-to-treat infections, necessitating the use of more potent or combination therapies. In terms of immune evasion, Staphylococcus cornubiensis can produce various factors that help it evade the host's immune response, such as biofilm formation and the production of surface proteins that inhibit phagocytosis. This ability to evade the immune system contributes to its pathogenicity, particularly in patients with compromised immune systems. While Staphylococcus cornubiensis is not commonly associated with large outbreaks, its role in nosocomial infections underscores the importance of monitoring and understanding its behavior in clinical settings. Overall, the organism's dual role as a commensal and a potential pathogen highlights the need for vigilance in its identification and management in healthcare environments.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Staphylococcus cornubiensis is a species of bacteria that is primarily associated with human skin and mucosal surfaces. This microorganism thrives in environments that are rich in nutrients and moisture, making it well-suited for colonization in areas such as the axillary region, groin, and interdigital spaces of the feet. These habitats provide a warm and humid environment, which is conducive to the growth of this organism. In terms of ecological roles, Staphylococcus cornubiensis is part of the normal skin flora, contributing to the maintenance of skin health by outcompeting pathogenic microorganisms. This symbiotic relationship is crucial as it helps to prevent infections by occupying niches that could otherwise be exploited by harmful bacteria. Additionally, this bacterium has been noted for its ability to adapt to various environmental stresses, such as changes in temperature and pH, which allows it to survive in diverse microhabitats on the human body. Its presence is often benign, but it can become opportunistic under certain conditions, such as when the skin barrier is compromised. Overall, Staphylococcus cornubiensis plays a significant role in the microbial ecosystem of the skin, highlighting the importance of microbial diversity in maintaining health and preventing disease.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Staphylococcus cornubiensis has shown potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This organism is known for its ability to produce certain enzymes that can be harnessed in biocatalysis, which is crucial for the synthesis of various chemical compounds. In the realm of waste management, Staphylococcus cornubiensis can play a role in biodegradation, where it aids in the breakdown of organic materials, thus contributing to the treatment of wastewater and the reduction of environmental pollutants. Its enzymatic activity can be particularly beneficial in the degradation of complex organic compounds, making it a valuable asset in the development of sustainable waste treatment processes. Moreover, the organism's potential in biofuel production is noteworthy. Through fermentation processes, Staphylococcus cornubiensis can convert biomass into biofuels, providing an alternative energy source that is more environmentally friendly compared to fossil fuels. This capability aligns with the growing demand for renewable energy solutions. In summary, Staphylococcus cornubiensis demonstrates significant promise in biotechnology, waste management, and biofuel production, with its involvement in biocatalysis, biodegradation, and fermentation processes highlighting its versatility and importance in various industrial sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro-1.5	google/gemma-7b-it	mistralai/mistral-7b-instruct	openchat/openchat-7b	anthropic/claude-3.5-sonnet	google/gemini-pro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	beta	beta ✓	N/A	N/A	beta ✓	N/A	N/A	N/A	N/A	N/A	gamma ✗	gamma ✗	N/A	N/A	N/A	N/A	alpha ✗	alpha ✗	beta ✓	beta ✓	beta ✓	beta ✓	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	coccus	coccus	coccus	coccus	coccus	bacillus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus

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