Corynebacterium belfantii

General Information

Corynebacterium belfantii is a fascinating microorganism within the genus Corynebacterium. This genus is known for its diverse range of species, many of which are significant in both medical and industrial contexts. Corynebacterium belfantii stands out due to its unique genetic and biochemical properties, which make it an interesting subject for research. One of the key characteristics of Corynebacterium belfantii is its ability to produce various enzymes that can be harnessed for biotechnological applications. These enzymes have potential uses in the degradation of complex organic compounds, making this bacterium valuable for environmental bioremediation efforts. Additionally, Corynebacterium belfantii has been studied for its role in the human microbiome. It is part of the normal flora of the skin and mucous membranes, contributing to the balance of microbial communities and potentially playing a role in preventing the colonization of pathogenic bacteria. From a genetic perspective, Corynebacterium belfantii possesses a genome that offers insights into the evolutionary pathways of the Corynebacterium genus. Comparative genomics studies have revealed that this species shares several conserved genes with other members of the genus, which are involved in essential metabolic pathways. This makes it a valuable model organism for studying the genetic basis of metabolic functions in Corynebacterium species. In summary, Corynebacterium belfantii is notable for its biotechnological potential, its role in the human microbiome, and its contributions to our understanding of microbial genetics and evolution. These attributes make it a subject of ongoing interest in various fields of microbiological research.

Corynebacterium belfantii is a fascinating species within the genus Corynebacterium, known for its unique biochemical properties and ecological significance. This organism is particularly interesting due to its ability to thrive in diverse environments, including soil and various animal hosts, which highlights its adaptability and potential role in different ecosystems. One of the most notable characteristics of C. belfantii is its production of specific enzymes that can degrade complex organic compounds. This capability makes it a valuable candidate for bioremediation efforts, where microorganisms are utilized to clean up contaminated environments. The enzymatic activity of C. belfantii could be harnessed to break down pollutants, contributing to environmental sustainability. Additionally, C. belfantii has been studied for its potential applications in biotechnology. Its metabolic pathways may offer insights into the development of novel bioprocesses for the production of biofuels or other bioproducts. The organism's genetic makeup and metabolic versatility present opportunities for genetic engineering and synthetic biology applications. Furthermore, research into C. belfantii can enhance our understanding of the Corynebacterium genus as a whole, which includes both pathogenic and non-pathogenic species. This knowledge is crucial for developing strategies to manage infections caused by related species while also exploring the beneficial aspects of non-pathogenic strains. In summary, Corynebacterium belfantii stands out due to its ecological versatility, potential biotechnological applications, and its role in expanding our understanding of microbial diversity and function. Its unique characteristics make it a subject of interest for researchers in microbiology, environmental science, and biotechnology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Corynebacteriaceae

Genus: Corynebacterium

Species: Corynebacterium belfantii

NCBI ID

2014537

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/947/533/635/GCF_947533635.1_FRC0723

File for sequence-based predictions:
GCF_947533635.1_FRC0723_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Corynebacterium belfantii is a member of the genus Corynebacterium, which includes several species known for their clinical significance. While Corynebacterium belfantii itself is less studied compared to its relatives, it is important to consider its potential implications in human health. Clinical relevance may arise from its role in infections, particularly in immunocompromised individuals, where opportunistic pathogens can lead to serious health issues. The organism may exhibit pathogenicity through mechanisms that allow it to evade the immune response, although specific strategies for Corynebacterium belfantii are not well-documented. Furthermore, the genus Corynebacterium is known for its potential to develop antimicrobial resistance, which poses challenges in treatment options for infections. The presence of such resistance mechanisms in related species raises concerns about the management of infections caused by Corynebacterium belfantii and its relatives. In terms of medical applications, while Corynebacterium belfantii has not been specifically linked to probiotics or vaccines, the broader genus has been explored for potential therapeutic uses. Understanding the interactions of Corynebacterium belfantii with the human microbiome could provide insights into its role in health and disease. Overall, while direct clinical implications of Corynebacterium belfantii remain to be fully elucidated, its association with the genus Corynebacterium warrants attention in clinical microbiology.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Corynebacterium belfantii is a species of bacteria that is primarily associated with the human microbiome, particularly in the skin and mucosal surfaces. This organism thrives in environments that are rich in organic material and moisture, making it well-suited for colonization in areas such as the axillary region and interdigital spaces of the feet. Its presence is often linked to the maintenance of skin health, as it plays a role in the microbial balance of the skin flora. In terms of ecological interactions, Corynebacterium belfantii can engage in symbiotic relationships with other skin-dwelling microorganisms. It may help to inhibit the growth of pathogenic bacteria by competing for resources and producing antimicrobial substances. This competitive exclusion is crucial for maintaining a healthy skin microbiome and preventing infections. Furthermore, this bacterium exhibits remarkable environmental adaptation capabilities, allowing it to survive in varying conditions of pH and moisture. Its ability to metabolize a range of substrates contributes to its resilience in diverse habitats, including those that are subject to fluctuations in temperature and humidity. Overall, Corynebacterium belfantii is an important player in the skin biome, contributing to the overall health and stability of the microbial community in which it resides.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Corynebacterium belfantii has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to participate in fermentation processes, which can be harnessed for the production of valuable metabolites such as amino acids and organic acids. For instance, Corynebacterium belfantii can be utilized in the fermentation of sugars to produce L-lysine, an essential amino acid widely used in animal feed and human nutrition. In the realm of waste management, Corynebacterium belfantii has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic compounds. This property can be leveraged in the treatment of industrial effluents, where the microorganism can help in the detoxification of harmful substances, thus contributing to more sustainable waste management practices. Moreover, the enzymatic activity of Corynebacterium belfantii is noteworthy, as it can produce specific enzymes that facilitate various biochemical reactions. These enzymes can be applied in pharmaceutical development, where they may assist in the synthesis of pharmaceutical compounds or the modification of existing drugs to enhance their efficacy. Overall, the diverse capabilities of Corynebacterium belfantii in fermentation, biodegradation, and enzyme production position it as a valuable organism in multiple industrial sectors, promoting sustainability and innovation.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	google/gemini-pro-1.5	google/gemma-7b-it	openchat/openchat-7b	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	perplexity/llama-3-sonar-small-32k-chat	mistralai/mistral-7b-instruct	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-4o	openai/gpt-4o	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	aerotolerant ✗	aerotolerant ✗	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	false	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	true	true	false	true	true	true	false	false	false	true	true	false	false	false	false	true	true	true	true	true	true	true	true	false	false	false	false
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	gamma	beta ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma ✓	gamma ✓	N/A	N/A	N/A	N/A	alpha ✗	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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