Chromobacterium alticapitis

General Information

Chromobacterium alticapitis is a fascinating microorganism that has garnered attention due to its unique ecological niche and potential biotechnological applications. This bacterium was first isolated from high-altitude environments, which suggests it has adapted to survive under conditions of low temperature and reduced oxygen levels. Such adaptations make C. alticapitis an interesting subject for studies on extremophiles and their survival mechanisms. One of the most intriguing aspects of Chromobacterium alticapitis is its ability to produce a variety of bioactive compounds. These compounds have shown potential in pharmaceutical applications, particularly as antimicrobial agents. The production of these bioactive molecules is not only of interest for drug development but also for understanding the metabolic pathways that enable the synthesis of such complex chemicals. Additionally, C. alticapitis exhibits a distinctive pigmentation, which is a hallmark of the Chromobacterium genus. This pigmentation is due to the production of violacein, a compound with antibacterial, antiviral, and anticancer properties. The study of violacein and its biosynthesis pathway in C. alticapitis could lead to new insights into natural product chemistry and the development of novel therapeutic agents. From an ecological perspective, the presence of Chromobacterium alticapitis in high-altitude environments indicates its role in the microbial communities of these unique ecosystems. Understanding its interactions with other microorganisms and its contribution to the nutrient cycles in such habitats can provide valuable information about microbial ecology and the resilience of life in extreme conditions. In summary, Chromobacterium alticapitis is a microorganism of significant interest due to its extremophilic adaptations, production of bioactive compounds, and ecological role in high-altitude environments. Its study not only advances our knowledge of microbial diversity and survival strategies but also holds promise for biotechnological and pharmaceutical innovations.

Chromobacterium alticapitis is a fascinating bacterium that has garnered attention due to its unique ecological niche and potential applications in biotechnology. Isolated from high-altitude environments, this organism thrives in conditions that are often inhospitable to many other microorganisms, showcasing its adaptability and resilience. Its ability to survive in such extreme conditions makes it a valuable subject for research into microbial ecology and the mechanisms of adaptation to stressors such as temperature fluctuations and nutrient limitations. One of the most intriguing aspects of C. alticapitis is its metabolic versatility. This bacterium is capable of utilizing a variety of carbon sources, which not only highlights its ecological role in nutrient cycling but also opens avenues for biotechnological applications, such as bioremediation and the production of bioactive compounds. Researchers are particularly interested in its potential to produce antimicrobial substances, which could lead to the development of new antibiotics in an era of increasing antibiotic resistance. Furthermore, C. alticapitis has been studied for its bioluminescent properties, which are not only captivating but also provide insights into the genetic and biochemical pathways involved in light production. This characteristic can be harnessed in various applications, including biosensors and environmental monitoring. In summary, Chromobacterium alticapitis stands out due to its unique habitat, metabolic capabilities, and potential for biotechnological innovations, making it a significant organism for both ecological and applied microbiological research.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Neisseriales

Family: Chromobacteriaceae

Genus: Chromobacterium

Species: Chromobacterium alticapitis

NCBI ID

2073169

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/924/365/GCF_002924365.1_ASM292436v1

File for sequence-based predictions:
GCF_002924365.1_ASM292436v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Chromobacterium alticapitis is a Gram-negative bacterium that has been isolated from various environmental sources, including soil and water. While it is not as widely studied as other members of the genus Chromobacterium, its clinical implications are becoming increasingly relevant. This organism has been associated with infections in humans, particularly in immunocompromised individuals. Clinical cases have reported its involvement in wound infections, bacteremia, and respiratory infections, highlighting its potential as an opportunistic pathogen. One of the significant concerns regarding C. alticapitis is its antimicrobial resistance. Isolates have shown resistance to multiple classes of antibiotics, which complicates treatment options for infections caused by this organism. The mechanisms of resistance may involve the production of beta-lactamases and efflux pumps, which are common strategies employed by Gram-negative bacteria to evade the effects of antimicrobial agents. In terms of immune evasion, C. alticapitis may utilize various strategies to survive within the host, including the ability to form biofilms, which can protect it from both the host immune response and antibiotic treatment. This characteristic is particularly concerning in clinical settings, as biofilm-associated infections are notoriously difficult to treat. While research on C. alticapitis is still emerging, its potential role in outbreaks and infections necessitates further investigation. Understanding its pathogenicity and interactions with the human immune system is crucial for developing effective therapeutic strategies and improving patient outcomes.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Chromobacterium alticapitis is a bacterium commonly found in various freshwater environments, particularly in tropical and subtropical regions. This microorganism thrives in soil and water ecosystems, often associated with decaying organic matter, which provides a rich source of nutrients. Its presence is frequently noted in wetlands and riverbanks, where it plays a crucial role in the decomposition process and nutrient cycling within these habitats. In terms of ecological interactions, C. alticapitis is known for its biodegradative capabilities, contributing to the breakdown of complex organic compounds. This process not only aids in nutrient recycling but also helps in maintaining the health of the ecosystem by preventing the accumulation of waste materials. Furthermore, it has been observed to exhibit antimicrobial properties, which can influence the microbial community structure in its environment. Additionally, C. alticapitis may engage in symbiotic relationships with other microorganisms, enhancing the overall functionality of the microbial community. Its adaptability to varying environmental conditions, such as changes in temperature and nutrient availability, allows it to thrive in diverse habitats, making it a significant player in the ecological dynamics of freshwater biomes.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Chromobacterium alticapitis has shown potential in various industrial applications due to its unique metabolic capabilities. One of the most notable areas is in biotechnology, where C. alticapitis is utilized for fermentation processes to produce valuable metabolites. This organism is known for its ability to synthesize bioactive compounds, which can be harnessed for pharmaceutical development, particularly in the production of antimicrobial agents and other therapeutic substances. In the realm of waste management, C. alticapitis has demonstrated effective biodegradation capabilities, particularly in the breakdown of complex organic pollutants. This makes it a candidate for bioremediation efforts, where it can help in the detoxification of contaminated environments, such as soil and water bodies affected by industrial waste. Furthermore, there is growing interest in the use of C. alticapitis in biofuel production. Its metabolic pathways can be exploited to convert biomass into biofuels through fermentation, potentially leading to sustainable energy solutions. The organism's ability to utilize various substrates enhances its applicability in this field. Overall, Chromobacterium alticapitis presents a multifaceted approach to addressing challenges in biotechnology, waste management, and biofuel production, making it a valuable organism for future industrial applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	N/A	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	false	false	false	false	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false
Host association	N/A	true	true	true	true	true	true	true	true	false	false	false	false	false	false	true	true	true	true	true	true	false	false	true	true	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	beta	beta	beta	beta	alpha	N/A	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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