Amycolatopsis tolypomycina

General Information

Amycolatopsis tolypomycina is a fascinating microorganism belonging to the genus Amycolatopsis, which is renowned for its ability to produce a wide array of bioactive compounds. One of the most noteworthy characteristics of A. tolypomycina is its production of tolypomycins, a group of antibiotics with significant potential in medical and pharmaceutical applications. These antibiotics exhibit strong activity against a variety of Gram-positive bacteria, including some strains that are resistant to other antibiotics, making A. tolypomycina a valuable subject of study in the fight against antibiotic resistance. Another unique feature of Amycolatopsis tolypomycina is its complex secondary metabolism, which allows it to synthesize a diverse range of secondary metabolites. This metabolic versatility not only contributes to its ecological success but also provides a rich source of novel compounds for drug discovery and development. From a research perspective, A. tolypomycina is also interesting due to its genetic and enzymatic machinery. The organism's genome encodes a variety of enzymes involved in the biosynthesis of its bioactive compounds, offering insights into the molecular mechanisms underlying antibiotic production. This makes A. tolypomycina an excellent model for studying the genetics and biochemistry of antibiotic biosynthesis. In summary, Amycolatopsis tolypomycina stands out due to its antibiotic production capabilities, metabolic diversity, and genetic insights it offers, making it a valuable organism for both basic and applied microbiological research.

Amycolatopsis tolypomycina is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, particularly antibiotics. This organism is part of the Amycolatopsis genus, which is recognized for its diverse metabolic capabilities and its role in natural product biosynthesis. One of the most notable features of A. tolypomycina is its production of the antibiotic tolyposin, which has shown efficacy against a range of pathogenic bacteria, making it a valuable candidate for pharmaceutical research and development. In addition to its antibiotic properties, A. tolypomycina is of interest due to its unique ecological niche. It is typically isolated from soil environments, where it plays a crucial role in the degradation of complex organic materials. This ability not only contributes to nutrient cycling in ecosystems but also highlights the potential of A. tolypomycina in bioremediation efforts, particularly in the breakdown of pollutants. Furthermore, the genetic and biochemical pathways involved in the synthesis of its secondary metabolites are a subject of ongoing research. Understanding these pathways can provide insights into the mechanisms of antibiotic resistance and the development of new antimicrobial agents. The organism's genome has been sequenced, offering a wealth of information for researchers interested in genetic engineering and synthetic biology. Overall, Amycolatopsis tolypomycina stands out as a significant organism in microbiology, not only for its antibiotic production but also for its ecological contributions and potential applications in biotechnology and medicine.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Pseudonocardiales

Family: Pseudonocardiaceae

Genus: Amycolatopsis

Species: Amycolatopsis tolypomycina

NCBI ID

208445

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/105/945/GCA_900105945.1_IMG-taxon_2634166899_annotated_assembly

File for sequence-based predictions:
GCA_900105945.1_IMG-taxon_2634166899_annotated_assembly_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The actinobacterium Amycolatopsis tolypomycina is primarily known for its role in the production of the antibiotic tolyposin, which has shown efficacy against various bacterial pathogens. This organism is significant in the field of antimicrobial research due to its ability to produce bioactive compounds that can be harnessed for therapeutic purposes. Its relevance extends to the study of antimicrobial resistance, as it provides insights into the mechanisms by which bacteria can evade the effects of antibiotics. In terms of human health, Amycolatopsis tolypomycina has been investigated for its potential use in developing new antibiotics, particularly in the face of rising resistance among common pathogens. The organism's unique metabolic pathways and genetic makeup make it a valuable candidate for biotechnological applications, including the production of novel antimicrobial agents. While there are no well-documented associations with human infections or outbreaks, the study of Amycolatopsis tolypomycina contributes to our understanding of the microbial ecosystem and its interactions with human health. Its role in immune evasion strategies is still under investigation, but its production of secondary metabolites suggests potential mechanisms that could influence host-pathogen interactions. Overall, Amycolatopsis tolypomycina represents a promising avenue for future research in clinical microbiology and pharmaceutical development.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Amycolatopsis tolypomycina is a species of actinobacteria that is primarily found in soil and decaying organic matter. This microorganism thrives in environments rich in organic material, where it plays a crucial role in the decomposition process. Its ability to degrade complex organic compounds makes it an important player in nutrient cycling within these ecosystems. Soil Biomes: In terrestrial ecosystems, A. tolypomycina is commonly associated with forest soils and agricultural lands. It contributes to soil health by breaking down organic residues, thus enhancing soil fertility and structure. The presence of this microorganism can indicate a healthy soil ecosystem, as it is often found in areas with high microbial diversity. Symbiotic Relationships: A. tolypomycina has been noted for its potential symbiotic relationships with plants, particularly in promoting plant growth through the production of growth-promoting substances. This interaction can enhance nutrient uptake in plants, demonstrating the organism's role in plant-microbe interactions. Adaptation to Environmental Conditions: This microorganism exhibits remarkable adaptability to varying environmental conditions, including changes in moisture and nutrient availability. Its resilience allows it to thrive in both aerobic and anaerobic conditions, making it a versatile inhabitant of diverse habitats. Overall, Amycolatopsis tolypomycina is a vital component of its ecological niche, contributing to the health and sustainability of the soil biome through its decomposition activities and interactions with other organisms.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Amycolatopsis tolypomycina has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for the production of antibiotics, particularly due to its ability to produce unique secondary metabolites. This capability is crucial in the development of new pharmaceuticals, as it can lead to the discovery of novel compounds that may combat antibiotic-resistant bacteria. In the realm of waste management, Amycolatopsis tolypomycina has been studied for its ability to degrade complex organic materials. This is particularly relevant in biodegradation processes, where the organism can break down pollutants and contribute to the detoxification of contaminated environments. Its enzymatic activity plays a key role in this process, allowing for the breakdown of various substrates, including those found in industrial waste. Furthermore, there is potential for Amycolatopsis tolypomycina in biofuel production. The organism's metabolic pathways can be harnessed to convert biomass into biofuels through fermentation processes. This application is particularly promising as it aligns with the growing demand for sustainable energy sources. Overall, Amycolatopsis tolypomycina demonstrates versatility across multiple industries, including pharmaceutical development, biotechnology, and environmental management, making it a valuable organism for future research and application.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	false	true	false	true	true	true	true	true	false	true	true	true	true	true	false	false	true	true	true	true	false	false
Animal pathogenicity	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	false	false	true	true	true	true	true	false	false	false	true	false	false	false	false	false	false	false	false	true	true	false	false
Host association	FALSE	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Spore formation	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus

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