Mycobacterium basiliense

General Information

Mycobacterium basiliense is a fascinating microorganism within the genus Mycobacterium. This species is particularly interesting due to its unique genetic makeup and potential applications in biotechnology and medicine. One of the most notable characteristics of M. basiliense is its ability to degrade complex organic compounds, making it a valuable candidate for bioremediation efforts. Additionally, M. basiliense has been studied for its resistance to various antibiotics, which provides insights into the mechanisms of antibiotic resistance and can inform the development of new therapeutic strategies. The organism's cell wall structure, rich in mycolic acids, contributes to its resilience and is a subject of extensive research. From a phylogenetic perspective, M. basiliense holds a unique position within the Mycobacterium genus, offering clues about the evolutionary pathways of mycobacteria. Its genome has been sequenced, revealing several genes that are of interest for their roles in pathogenicity and environmental adaptation. Overall, Mycobacterium basiliense is a microorganism of significant interest due to its biotechnological potential, antibiotic resistance mechanisms, and evolutionary insights. Continued research on this species promises to uncover further applications and deepen our understanding of mycobacterial biology.

Mycobacterium basiliense is a species of the genus Mycobacterium that has garnered interest due to its unique ecological niche and potential implications in human health. This organism is primarily known for its ability to thrive in various environmental conditions, particularly in soil and water, which makes it an important player in the microbial ecosystem. Its resilience and adaptability to different environments highlight its evolutionary success. One of the most intriguing aspects of M. basiliense is its potential role in bioremediation. Research has indicated that this species may possess the ability to degrade complex organic compounds, including pollutants, which could be harnessed for environmental cleanup efforts. This characteristic positions M. basiliense as a valuable organism in the field of environmental microbiology. Additionally, M. basiliense has been studied for its antimicrobial properties. Some strains have shown activity against various pathogens, making them a subject of interest for the development of new antimicrobial agents. This potential could be particularly significant in the context of rising antibiotic resistance, as researchers explore alternative sources for effective treatments. Furthermore, the genetic and metabolic pathways of M. basiliense are of considerable interest. Understanding these pathways can provide insights into the mechanisms of survival and adaptation in harsh environments, which may have broader implications for the study of other mycobacterial species, including those that are pathogenic to humans. In summary, Mycobacterium basiliense stands out due to its ecological versatility, potential applications in bioremediation, and promising antimicrobial properties, making it a noteworthy subject for ongoing research in microbiology and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium basiliense

NCBI ID

2094119

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/292/015/GCA_900292015.1_MB901379

File for sequence-based predictions:
GCA_900292015.1_MB901379_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium basiliense is a member of the Mycobacterium genus, which is known for its clinical significance, particularly in relation to infections and disease associations. While it is less commonly discussed than its more notorious relatives, such as Mycobacterium tuberculosis, M. basiliense has been implicated in a variety of clinical scenarios, particularly in immunocompromised patients. Skin infections and soft tissue infections have been documented, often presenting as chronic lesions that can be difficult to treat due to the organism's inherent antimicrobial resistance mechanisms. The pathogenicity of M. basiliense is attributed to its ability to evade the immune response through various strategies, including the modulation of macrophage activity and the formation of biofilms, which protect it from both the host's immune system and antibiotic treatment. This organism has been associated with cases of nontuberculous mycobacterial infections, which can lead to significant morbidity, especially in patients with underlying health conditions. In terms of antimicrobial resistance, M. basiliense exhibits resistance to multiple first-line antibiotics, complicating treatment regimens. This resistance is a growing concern in clinical settings, as it limits the options available for effective therapy. While there is ongoing research into the potential use of mycobacteria in therapeutics and vaccines, the clinical implications of M. basiliense primarily revolve around its role as a pathogen in human health, particularly in the context of opportunistic infections. Further studies are needed to fully elucidate its clinical relevance and potential applications in medicine.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium basiliense has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to degrade complex organic compounds, making it valuable in biodegradation processes. For instance, Mycobacterium basiliense can be utilized in the treatment of contaminated environments, effectively breaking down pollutants such as hydrocarbons and other toxic substances, thus contributing to environmental remediation efforts. In the realm of biofuel production, Mycobacterium basiliense has been studied for its capacity to metabolize certain substrates that can be converted into biofuels. Its enzymatic activity can facilitate the breakdown of lignocellulosic biomass, which is a critical step in the production of second-generation biofuels through fermentation processes. Moreover, this microorganism has potential applications in pharmaceutical development due to its unique metabolic pathways. It can be explored for the production of bioactive compounds that may have therapeutic properties. The ability of Mycobacterium basiliense to produce specific enzymes can also be harnessed in the development of novel drugs or as biocatalysts in various chemical reactions. Overall, Mycobacterium basiliense represents a promising candidate for multiple industrial applications, particularly in waste treatment, biodegradation, and enzyme production, highlighting its versatility and importance in sustainable practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro	anthropic/claude-3-haiku:beta	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	false	false	true	true	false	false	false	false	false	true	false	false	false	false	true	true	true	true	false	false	true	true	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗
Health association	N/A	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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