Kribbella monticola

General Information

Kribbella monticola is a fascinating microorganism belonging to the genus Kribbella. This bacterium is particularly interesting due to its unique ecological niche and biotechnological potential. Isolated from soil samples in mountainous regions, K. monticola thrives in environments that are often challenging for other microorganisms, indicating its robust adaptability and resilience. One of the most compelling aspects of Kribbella monticola is its ability to produce a variety of bioactive compounds. These compounds have shown potential in pharmaceutical applications, particularly as antibiotics and antifungal agents. The metabolic pathways involved in the synthesis of these compounds are of significant interest to researchers aiming to discover new drugs and understand microbial secondary metabolism. Additionally, K. monticola exhibits a remarkable capacity for biodegradation. It can break down complex organic materials, making it a valuable candidate for environmental bioremediation projects. This ability to degrade pollutants and contribute to soil health underscores its ecological importance. From a taxonomic perspective, Kribbella monticola adds to the diversity of the Kribbella genus, which is known for its members' distinctive morphological and genetic traits. The study of K. monticola can provide insights into the evolutionary pathways and genetic adaptations that enable survival in extreme environments. In summary, Kribbella monticola is a microorganism of significant interest due to its bioactive compound production, biodegradation capabilities, and ecological adaptability. Its study not only advances our understanding of microbial diversity but also holds promise for practical applications in medicine and environmental science.

Kribbella monticola is a fascinating actinobacterium that was first isolated from soil samples in mountainous regions, which is reflected in its name, meaning 'mountain dweller.' This organism is particularly interesting due to its unique ecological niche, thriving in high-altitude environments where it plays a crucial role in nutrient cycling and soil health. Its ability to adapt to extreme conditions makes it a valuable subject for research in microbial ecology and environmental microbiology. One of the standout features of K. monticola is its potential for biotechnological applications. Like many actinobacteria, it is known to produce a variety of secondary metabolites, including antibiotics and other bioactive compounds. This characteristic positions K. monticola as a promising candidate for drug discovery, particularly in the search for new antimicrobial agents in an era of increasing antibiotic resistance. Additionally, K. monticola has been studied for its genetic diversity and evolutionary adaptations. Its genome contains genes that may confer advantages in harsh environments, making it a model organism for understanding microbial survival strategies. Researchers are particularly interested in the metabolic pathways that allow it to utilize various substrates, which could have implications for bioremediation and sustainable agriculture. In summary, Kribbella monticola stands out not only for its ecological significance but also for its potential contributions to biotechnology and medicine, making it a valuable organism for ongoing research in multiple scientific fields.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Propionibacteriales

Family: Kribbellaceae

Genus: Kribbella

Species: Kribbella monticola

NCBI ID

2185285

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/003/261/635/GCF_003261635.1_ASM326163v1

File for sequence-based predictions:
GCF_003261635.1_ASM326163v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Kribbella monticola is a member of the Actinobacteria phylum and has been studied for its potential clinical implications. While it is primarily known as a soil bacterium, its relevance in human health is emerging. Clinical studies have suggested that Kribbella monticola may be associated with certain infections, particularly in immunocompromised patients, although specific disease associations are still being elucidated. Its pathogenicity is not well characterized, but it has been isolated from clinical specimens, indicating a potential role in opportunistic infections. One of the notable aspects of Kribbella monticola is its potential for antimicrobial resistance. Like many Actinobacteria, it may possess intrinsic resistance mechanisms that could complicate treatment options. Understanding its resistance patterns is crucial for developing effective therapeutic strategies. In terms of immune evasion, there is limited information available, but it is hypothesized that, similar to other bacteria in its class, it may employ strategies to evade host immune responses, which could contribute to its pathogenic potential in susceptible individuals. Currently, there are no widely recognized medical applications such as probiotics or vaccines associated with Kribbella monticola, but ongoing research may uncover beneficial properties or therapeutic uses in the future. Overall, while Kribbella monticola is not yet a well-established pathogen, its presence in clinical settings warrants further investigation to fully understand its implications for human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Kribbella monticola is a species of actinobacteria that is primarily associated with mountainous regions and soil environments. This microorganism thrives in high-altitude ecosystems, where it plays a significant role in nutrient cycling and soil health. Its presence is often linked to the decomposition of organic matter, contributing to the mineralization process that enriches the soil with essential nutrients. In these alpine biomes, K. monticola can be found in rocky soils and forest floors, where it interacts with various plant roots, potentially forming symbiotic relationships that enhance plant growth and resilience. The organism is adapted to withstand the harsh conditions of its environment, including low temperatures and high UV radiation, showcasing its remarkable ability to thrive in extreme habitats. Furthermore, K. monticola is known for its production of bioactive compounds, which can have implications for antimicrobial activity and biotechnological applications. Its ecological role extends to influencing microbial community dynamics, thereby affecting the overall health and stability of the ecosystem it inhabits.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Kribbella monticola has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where Kribbella monticola is utilized for its ability to produce a range of enzymes that can be harnessed in different processes. For instance, its enzymatic activity is particularly valuable in biodegradation, where it can break down complex organic materials, making it useful in waste management and environmental remediation efforts. In the realm of waste management, Kribbella monticola can contribute to the treatment of organic waste through biodegradation processes, effectively reducing the volume of waste and minimizing environmental impact. This capability is crucial in developing sustainable waste treatment solutions. Additionally, there is potential for Kribbella monticola in biofuel production. Its metabolic pathways may be exploited to enhance the fermentation processes involved in converting biomass into biofuels, thereby contributing to renewable energy solutions. Furthermore, the pharmaceutical industry may benefit from Kribbella monticola through its production of bioactive compounds, which can be explored for their therapeutic properties. This includes the potential for developing new antibiotics or other medicinal compounds, showcasing the organism's versatility in pharmaceutical development. Overall, Kribbella monticola represents a promising candidate for various industrial applications, particularly in fermentation, biodegradation, and enzyme production, making it a valuable asset in the fields of biotechnology, waste management, biofuel production, and pharmaceuticals.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	google/gemma-7b-it	google/gemma-7b-it	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	false	false	false	false	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	false	false	true	true	false	true	true	false	false	false	false	true	true	false	false	true	true	false	false	true	true	false	false	false	false	false	false
Host association	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Hemolysis	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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