Brachybacterium muris

General Information

Brachybacterium muris is a fascinating microorganism that has garnered interest due to its unique habitat and potential applications in biotechnology. This bacterium was originally isolated from the liver of a laboratory mouse, which highlights its potential role in the microbiome of mammals and its possible implications in health and disease research. One of the key characteristics of Brachybacterium muris is its ability to thrive in a mammalian host environment, which suggests it may have specialized adaptations that allow it to interact with host tissues or immune systems. This makes it a valuable model for studying host-microbe interactions and understanding how bacteria can influence mammalian physiology. Additionally, Brachybacterium muris has shown potential in biotechnological applications. Its metabolic capabilities could be harnessed for the production of valuable biochemicals or for bioremediation purposes. The study of its genome and metabolic pathways could reveal novel enzymes or biochemical processes that are of industrial interest. In summary, Brachybacterium muris is not only interesting due to its unique origin and habitat but also holds promise for future research in microbiology, biotechnology, and medical science. Its study could lead to new insights into microbial ecology, host interactions, and potential biotechnological innovations.

Brachybacterium muris is a fascinating species of bacteria that has garnered attention due to its unique ecological niche and potential applications in biotechnology. This organism was first isolated from the skin of a mouse, which highlights its adaptability to mammalian hosts and suggests a possible role in the skin microbiome. Its ability to thrive in such environments makes it an interesting subject for studies on host-microbe interactions. One of the most notable characteristics of Brachybacterium muris is its capacity to degrade complex organic compounds, including various aromatic compounds. This metabolic versatility positions it as a potential candidate for bioremediation efforts, particularly in the breakdown of environmental pollutants. Research into its metabolic pathways could lead to innovative strategies for cleaning up contaminated sites. Additionally, Brachybacterium muris has been studied for its production of antimicrobial compounds, which may have implications for developing new antibiotics. The exploration of its secondary metabolites could contribute to the ongoing search for novel antimicrobial agents in an era of increasing antibiotic resistance. Overall, Brachybacterium muris stands out not only for its ecological significance but also for its potential contributions to environmental science and medicine, making it a valuable organism for ongoing research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Micrococcales

Family: Dermabacteraceae

Genus: Brachybacterium

Species: Brachybacterium muris

NCBI ID

219301

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/907/455/GCA_016907455.1_ASM1690745v1

File for sequence-based predictions:
GCA_016907455.1_ASM1690745v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Brachybacterium muris is a Gram-positive bacterium that has been isolated from various environments, including soil and animal sources. While it is not commonly associated with human disease, its clinical relevance has been noted in specific contexts. Infections caused by Brachybacterium muris are rare but can occur, particularly in immunocompromised individuals. The organism has been implicated in cases of soft tissue infections and has been isolated from clinical specimens, suggesting a potential role as an opportunistic pathogen. One of the notable aspects of Brachybacterium muris is its ability to exhibit antimicrobial resistance, particularly to beta-lactam antibiotics. This resistance can complicate treatment options for infections, highlighting the importance of susceptibility testing in clinical settings. The mechanisms of resistance may involve the production of beta-lactamases or alterations in target sites, which are common strategies employed by various bacteria to evade antimicrobial therapy. In terms of its interaction with the human body, Brachybacterium muris may possess immune evasion strategies that allow it to persist in host tissues. These strategies could include the ability to form biofilms, which protect the bacteria from both the host immune response and antibiotic treatment. While there are no widely recognized medical applications of Brachybacterium muris in terms of probiotics or therapeutics, its presence in clinical samples underscores the need for ongoing surveillance and research to better understand its role in human health and disease. Further studies are necessary to elucidate its pathogenic potential and to develop effective management strategies for infections associated with this organism.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Brachybacterium muris is a species of bacteria that is primarily associated with mammalian habitats, particularly within the gastrointestinal tracts of rodents. This organism thrives in the microbial communities of the gut, where it plays a significant role in the digestion of complex carbohydrates and the fermentation of dietary fibers. Its presence is crucial for maintaining a balanced gut microbiome, contributing to the overall health of its host by aiding in nutrient absorption and metabolism. In addition to its role in the gut, Brachybacterium muris can also be found in soil environments, where it participates in the decomposition of organic matter. This bacterium contributes to nutrient cycling, particularly in the breakdown of plant materials, which enriches the soil and supports plant growth. Its ability to adapt to varying soil moisture levels and pH conditions allows it to thrive in diverse terrestrial ecosystems. Furthermore, Brachybacterium muris exhibits notable interactions with other microorganisms, often engaging in symbiotic relationships that enhance its survival and functionality within these biomes. For instance, it may collaborate with other gut bacteria to optimize fermentation processes, thereby improving the overall efficiency of nutrient utilization in its host. Overall, Brachybacterium muris is an essential component of both gut microbiomes and soil ecosystems, showcasing its adaptability and ecological significance in various environments.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Brachybacterium muris has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to perform biodegradation, which makes it valuable in the treatment of waste materials, especially in environments contaminated with organic pollutants. Its enzymatic activity allows it to break down complex compounds, contributing to the detoxification of hazardous waste. In the realm of biotechnology, Brachybacterium muris can be utilized in fermentation processes, where it may assist in the production of bioactive compounds. These compounds can have applications in the development of pharmaceuticals, including antibiotics and other therapeutic agents. The organism's metabolic pathways are of interest for the synthesis of valuable metabolites that can be harnessed in drug development. Moreover, its role in biofuel production is being explored, as it may contribute to the breakdown of biomass into fermentable sugars, which can then be converted into biofuels. This capability positions Brachybacterium muris as a potential player in the transition towards sustainable energy sources. Overall, the diverse applications of Brachybacterium muris highlight its significance in advancing industrial processes and promoting environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemma-7b-it	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3.5-sonnet	google/gemini-pro	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	openchat/openchat-7b	openchat/openchat-7b	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	N/A	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerotolerant ✗	aerotolerant ✗	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	false	false	false	false	false	false	true	true	true	true	false	false
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	false	false	true	true	true	true	false	false
Host association	N/A	false	false	true	true	true	true	true	false	true	true	true	true	false	false	false	false	true	true	false	false	false	false	true	true	false	false	false	false
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus	bacillus	coccus	coccus	coccus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus	coccus	coccus	coccus	coccus	bacillus	bacillus	coccus	coccus

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