Mycobacterium saskatchewanense

General Information

Mycobacterium saskatchewanense is a species of nontuberculous mycobacteria (NTM) that has garnered interest due to its unique genetic and biochemical properties. This organism was first isolated from a patient in Saskatchewan, Canada, which is reflected in its name. One of the key characteristics of M. saskatchewanense is its ability to grow at relatively low temperatures compared to other mycobacteria, making it an interesting subject for studying microbial adaptation to different environmental conditions. From a research perspective, M. saskatchewanense is valuable because it contributes to our understanding of the diversity within the Mycobacterium genus. Its genetic makeup provides insights into the evolutionary pathways that differentiate pathogenic mycobacteria, such as Mycobacterium tuberculosis, from non-pathogenic or opportunistic species. Additionally, the study of M. saskatchewanense can help in the development of diagnostic tools and treatments for NTM infections, which are increasingly recognized as significant health concerns, particularly in immunocompromised individuals. Another noteworthy aspect of M. saskatchewanense is its potential role in environmental microbiology. Its presence in natural water sources and soil suggests that it could be involved in nutrient cycling and other ecological processes. Understanding its interactions with other microorganisms and its environmental niches can provide broader insights into microbial ecology and the potential biotechnological applications of mycobacteria. Overall, Mycobacterium saskatchewanense stands out due to its unique growth characteristics, its contribution to the understanding of mycobacterial diversity, and its potential implications for both medical and environmental microbiology.

Mycobacterium saskatchewanense is a species of the genus Mycobacterium that was first identified in Saskatchewan, Canada. This organism is particularly interesting due to its unique ecological niche and potential implications in environmental microbiology. It has been isolated from soil samples, indicating its role in the soil microbiome and its interactions with other microbial communities. The ability of M. saskatchewanense to thrive in diverse environmental conditions makes it a valuable subject for studying microbial adaptation and resilience. One of the notable characteristics of Mycobacterium saskatchewanense is its potential for bioremediation. Research has suggested that this species may possess the capability to degrade various environmental pollutants, which could be harnessed for cleaning contaminated sites. This aspect opens avenues for exploring its enzymatic pathways and metabolic processes, which could lead to the development of novel biotechnological applications. Furthermore, M. saskatchewanense contributes to the understanding of the evolutionary relationships within the Mycobacterium genus. Its genetic makeup and phylogenetic position provide insights into the diversification of mycobacterial species, particularly those that are not pathogenic. This can enhance our knowledge of microbial evolution and the ecological roles of mycobacteria in various environments. In summary, Mycobacterium saskatchewanense stands out due to its ecological significance, potential for bioremediation, and contributions to evolutionary studies within the Mycobacterium genus, making it a valuable organism for ongoing research in microbiology and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium saskatchewanense

NCBI ID

220927

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/010/729/105/GCA_010729105.1_ASM1072910v1

File for sequence-based predictions:
GCA_010729105.1_ASM1072910v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium saskatchewanense is a member of the Mycobacterium genus, which is known for its clinical significance in human health. This species has been associated with infections that can lead to pulmonary disease and cutaneous lesions. While it is not as widely recognized as other mycobacterial species, such as Mycobacterium tuberculosis, its role in human disease is becoming increasingly acknowledged, particularly in immunocompromised patients. One of the notable aspects of M. saskatchewanense is its potential for antimicrobial resistance. Like other mycobacteria, it may exhibit resistance to common antibiotics, complicating treatment options. This resistance can be attributed to its unique cell wall structure, which limits the penetration of many antimicrobial agents. In terms of immune evasion, M. saskatchewanense may employ strategies similar to those of other mycobacteria, such as inhibiting phagosome-lysosome fusion within macrophages, allowing it to survive and replicate within host cells. This ability to evade the immune response poses challenges for effective treatment and highlights the need for ongoing research into its pathogenic mechanisms. Currently, there are no widely recognized medical applications, such as probiotics or vaccines, specifically targeting M. saskatchewanense. However, understanding its clinical implications is crucial for improving diagnostic and therapeutic strategies in managing infections caused by this organism. As more cases are reported, particularly in specific geographic regions, the clinical relevance of Mycobacterium saskatchewanense will likely continue to evolve.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium saskatchewanense is a species of bacteria that is primarily associated with soil environments and freshwater ecosystems. This microorganism thrives in nutrient-rich substrates, often found in areas with high organic matter content, such as decaying plant material and wetlands. Its presence is particularly noted in regions with a temperate climate, where it can adapt to varying moisture levels and temperatures. In terms of ecological roles, Mycobacterium saskatchewanense is known for its ability to degrade complex organic compounds, contributing to the nutrient cycling within its habitat. This degradation process is essential for maintaining soil health and fertility, as it helps release nutrients back into the ecosystem, making them available for other organisms. Additionally, this bacterium may engage in symbiotic relationships with various plants, aiding in their growth by enhancing nutrient availability. Its interactions with other microorganisms in the soil can also promote a balanced microbial community, which is crucial for ecosystem stability. Overall, Mycobacterium saskatchewanense plays a significant role in its biome by participating in decomposition processes, supporting plant life, and contributing to the overall health of soil and freshwater ecosystems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium saskatchewanense has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium saskatchewanense may play a role in the conversion of biomass into biofuels through fermentation processes. This capability is particularly valuable in the development of sustainable energy sources, as it can help in the efficient utilization of agricultural waste. Furthermore, there is potential for Mycobacterium saskatchewanense in pharmaceutical development. Its unique metabolic pathways may lead to the discovery of novel compounds that could be harnessed for therapeutic purposes. The organism's ability to produce specific metabolites can be explored for their medicinal properties, contributing to the pharmaceutical industry. Overall, Mycobacterium saskatchewanense presents a promising avenue for research and application in environmental biotechnology, renewable energy, and healthcare, with its capabilities in biodegradation, fermentation, and potential enzyme production being particularly noteworthy.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	google/gemini-pro	anthropic/claude-3-haiku:beta	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat
Motility	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	N/A	false	true	false	true	false	false	true	false	false	true	true	false	false	true	true	true	false	false	false	false	true	true	false	false	false	false	true	true
Biofilm formation	N/A	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗
Health association	N/A	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Hemolysis	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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