Mycobacterium kyogaense

General Information

Mycobacterium kyogaense is a recently identified species within the genus Mycobacterium, which is renowned for its diverse and often pathogenic members. This species was first isolated from environmental samples, indicating its potential role in natural ecosystems. One of the most intriguing aspects of M. kyogaense is its genetic makeup, which shows a unique combination of genes that are not commonly found in other mycobacteria. This genetic distinctiveness suggests that M. kyogaense may have evolved specific adaptations to its environment, making it a valuable subject for studying microbial evolution and ecology. From a research perspective, M. kyogaense is particularly interesting due to its potential applications in biotechnology and medicine. The organism's unique metabolic pathways could be harnessed for the development of novel antibiotics or bioremediation strategies. Additionally, studying M. kyogaense can provide insights into the mechanisms of mycobacterial resistance and survival, which are critical for understanding and combating more pathogenic relatives like Mycobacterium tuberculosis. Overall, Mycobacterium kyogaense stands out as a species with significant scientific interest due to its unique genetic characteristics and potential applications in various fields of research.

Mycobacterium kyogaense is a species of the genus Mycobacterium that has garnered interest due to its unique ecological niche and potential implications in public health. This organism was first isolated from environmental samples in Uganda, specifically from water sources, which highlights its adaptability to aquatic environments. Its ability to thrive in such habitats makes it a subject of study for understanding microbial diversity in freshwater ecosystems. One of the most intriguing aspects of M. kyogaense is its genetic makeup, which reveals a distinct phylogenetic position within the Mycobacterium genus. This uniqueness suggests that it may possess novel metabolic pathways or resistance mechanisms that are not found in other closely related species. Such characteristics could provide insights into the evolution of mycobacteria and their adaptation strategies. Furthermore, preliminary studies indicate that M. kyogaense may produce bioactive compounds, which could have potential applications in biotechnology and pharmaceuticals. The exploration of these compounds could lead to the discovery of new antibiotics or other therapeutic agents, making this organism valuable for research in drug development. Overall, Mycobacterium kyogaense stands out not only for its ecological significance but also for its potential contributions to our understanding of microbial interactions and the development of new biotechnological applications.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium kyogaense

NCBI ID

2212479

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/003/254/575/GCF_003254575.1_ASM325457v1

File for sequence-based predictions:
GCF_003254575.1_ASM325457v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium kyogaense is a member of the Mycobacterium genus, which is known for its clinical significance in human health. This species has been associated with pulmonary infections and is particularly relevant in regions where tuberculosis (TB) is endemic. While it is less common than other mycobacterial species, its identification is crucial due to its potential to cause disease, especially in immunocompromised individuals. Pathogenicity of M. kyogaense is linked to its ability to evade the immune response through various mechanisms, including the modulation of macrophage activity and the formation of granulomas. These strategies allow the bacterium to persist within the host and contribute to chronic infections. In terms of antimicrobial resistance, there is limited data available, but like other mycobacteria, M. kyogaense may exhibit resistance to standard anti-tubercular drugs, which complicates treatment options. This underscores the importance of accurate identification and susceptibility testing in clinical settings. Currently, there are no widely recognized medical applications such as probiotics or vaccines specifically targeting M. kyogaense. However, its role in the broader context of mycobacterial infections highlights the need for ongoing research into effective therapeutic strategies and public health measures to control its spread. Overall, Mycobacterium kyogaense serves as a reminder of the complexities associated with mycobacterial diseases and the importance of vigilance in diagnosing and managing infections caused by less common mycobacterial species.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium kyogaense is a species of bacteria that has been primarily isolated from freshwater environments, particularly in regions associated with wetlands and lakes. This microorganism thrives in these aquatic habitats, where it plays a significant role in the nutrient cycling processes. Its presence is often linked to the breakdown of organic matter, contributing to the overall health of the ecosystem by facilitating the decomposition process and recycling nutrients back into the environment. In addition to its ecological role, Mycobacterium kyogaense exhibits notable interactions with its surroundings. It is known to engage in symbiotic relationships with various aquatic organisms, which can enhance the nutrient availability for both the bacteria and its partners. This symbiosis can be particularly important in nutrient-poor environments, where the bacteria may assist in the uptake of essential nutrients for other organisms. Furthermore, Mycobacterium kyogaense demonstrates remarkable environmental adaptation capabilities, allowing it to survive in varying conditions of temperature and pH commonly found in freshwater ecosystems. This adaptability not only aids in its survival but also allows it to occupy a niche that may be less competitive, thus ensuring its persistence in these habitats. Overall, the ecological significance of Mycobacterium kyogaense in freshwater biomes underscores its role in maintaining the balance of aquatic ecosystems, highlighting the intricate relationships between microorganisms and their environments.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium kyogaense has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium kyogaense may play a role in the fermentation of biomass, converting organic materials into biofuels through fermentation processes. This capability is particularly valuable in the development of sustainable energy sources, as it can help in the conversion of agricultural waste into usable fuel. Moreover, there is potential for Mycobacterium kyogaense in pharmaceutical development. Its unique metabolic pathways may lead to the discovery of novel compounds that could be utilized in drug formulation, particularly in the development of antibiotics or other therapeutic agents. The organism's ability to produce specific enzymes can also be harnessed for enzyme production, which is crucial in various biotechnological applications, including the synthesis of pharmaceuticals and biocatalysts. Overall, Mycobacterium kyogaense presents a promising avenue for research and development across multiple industries, particularly in enhancing processes related to biotechnology, waste management, and pharmaceuticals.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	false	true	true	true	false	false	true	true	false	false	false	false	true	true	false	false	true	false	false	false	false	false	false	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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