Bartonella krasnovii

General Information

Bartonella krasnovii is a fascinating microorganism belonging to the genus Bartonella, which is known for its complex interactions with mammalian hosts and arthropod vectors. This species was identified relatively recently, adding to the growing list of Bartonella species that are of significant interest in both medical and veterinary research. One of the key characteristics of B. krasnovii is its association with fleas, particularly those that infest small mammals. This relationship is crucial for understanding the ecology and epidemiology of Bartonella infections, as fleas serve as vectors that facilitate the transmission of these bacteria between hosts. What makes B. krasnovii particularly valuable from a research perspective is its potential role in zoonotic diseases. While the pathogenicity of B. krasnovii in humans is not yet fully established, other Bartonella species are known to cause a range of illnesses, including cat scratch disease, trench fever, and endocarditis. Therefore, studying B. krasnovii can provide insights into the mechanisms of host-pathogen interactions, vector biology, and the evolution of virulence factors within the Bartonella genus. Another unique aspect of B. krasnovii is its genetic makeup, which can offer clues about the evolutionary history and diversification of Bartonella species. Comparative genomic studies can help identify genes that are responsible for host specificity, vector competence, and pathogenicity. This information is crucial for developing diagnostic tools, treatments, and preventive measures against Bartonella-related diseases. In summary, Bartonella krasnovii is an intriguing microorganism that holds significant promise for advancing our understanding of vector-borne diseases, host-pathogen dynamics, and microbial evolution. Its study not only contributes to the broader field of infectious diseases but also has practical implications for public health and veterinary medicine.

Bartonella krasnovii is a fascinating bacterium that belongs to the genus Bartonella, which is known for its association with various animal hosts and its role in human diseases. This particular species was first identified in 2007 and is primarily associated with rodents, particularly in the context of its ecological niche. What makes B. krasnovii particularly interesting is its potential as a zoonotic pathogen, which means it can be transmitted from animals to humans, although its pathogenicity in humans is not yet fully understood. One of the unique aspects of B. krasnovii is its ability to survive within the host's bloodstream, which is characteristic of many members of the Bartonella genus. This survival strategy allows it to evade the host's immune response, making it a subject of interest for researchers studying host-pathogen interactions. The bacterium's genetic diversity and adaptability also provide valuable insights into evolutionary biology and the mechanisms of disease emergence. Furthermore, B. krasnovii has been studied for its potential role in vector-borne diseases, as it can be transmitted by ectoparasites such as fleas and ticks. This aspect opens avenues for research into the ecology of disease transmission and the dynamics of host-vector interactions. Understanding the ecology and epidemiology of B. krasnovii could have significant implications for public health, especially in regions where rodent populations are prevalent. Overall, Bartonella krasnovii represents a compelling subject for ongoing research in microbiology, ecology, and infectious disease.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Alphaproteobacteria

Order: Hyphomicrobiales

Family: Bartonellaceae

Genus: Bartonella

Species: Bartonella krasnovii

NCBI ID

2267275

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/003/606/345/GCF_003606345.3_ASM360634v3

File for sequence-based predictions:
GCF_003606345.3_ASM360634v3_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Bartonella krasnovii is a member of the genus Bartonella, which is known for its association with various infections in humans and animals. While B. krasnovii is less studied compared to other species like Bartonella henselae, it has been implicated in certain clinical conditions, particularly in immunocompromised individuals. Clinical relevance includes its potential role in causing bacteremia and endocarditis, although these associations are not as well-documented as with other Bartonella species. One of the notable aspects of B. krasnovii is its ability to evade the immune response through various mechanisms, including the modulation of host cell signaling pathways and the ability to persist within erythrocytes. This immune evasion can complicate diagnosis and treatment, as the organism may remain undetected in the bloodstream. In terms of antimicrobial resistance, there is limited data available specifically for B. krasnovii, but members of the Bartonella genus are generally known to exhibit resistance to common antibiotics, which poses challenges in treatment. Emerging resistance patterns may necessitate the use of alternative therapeutic strategies, including the potential use of combination therapies. While B. krasnovii is not commonly associated with large outbreaks, its presence in certain animal reservoirs suggests a potential for zoonotic transmission, which could have implications for public health. Further research is needed to fully elucidate the clinical significance of B. krasnovii and its role in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Bartonella krasnovii is a bacterium primarily associated with the wildlife-associated habitats of its hosts, particularly rodents and other small mammals. This microorganism is often found in temperate forests and grasslands, where it can thrive in the presence of its natural hosts. The ecological niche of B. krasnovii is closely linked to the blood-feeding ectoparasites, such as fleas and ticks, which serve as vectors for its transmission. These ectoparasites play a crucial role in the life cycle of the bacterium, facilitating its spread within populations of small mammals. In these biomes, B. krasnovii exhibits notable interactions with its surroundings, particularly through its symbiotic relationships with its hosts. The bacterium can influence the health and behavior of its hosts, potentially affecting their survival and reproduction. This interaction underscores the importance of B. krasnovii in the dynamics of ecosystem health and biodiversity. Furthermore, B. krasnovii demonstrates remarkable environmental adaptation capabilities, allowing it to persist in various conditions within its habitats. Its presence in these ecosystems highlights the interconnectedness of microbial life with larger ecological processes, emphasizing the role of microorganisms in maintaining the balance of forest and grassland ecosystems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Bartonella krasnovii has garnered attention for its potential applications in various industrial sectors, particularly in biotechnology and pharmaceutical development. This organism is known for its role in pathogen detection and diagnostic applications, which can be crucial in the development of new diagnostic tools for vector-borne diseases. Its unique genetic and biochemical properties allow for the exploration of novel therapeutic targets, making it a candidate for drug development against diseases caused by related pathogens. In the realm of biotechnology, Bartonella krasnovii can be utilized in the study of host-pathogen interactions, which is essential for understanding disease mechanisms and developing effective treatments. This research can lead to the creation of vaccines or therapeutics that target specific pathways involved in infection. Moreover, the organism's ability to survive in various environments suggests potential applications in bioremediation, where it could be studied for its interactions with other microorganisms in contaminated sites. This could lead to innovative strategies for waste management and the degradation of pollutants. While the direct applications of Bartonella krasnovii in biofuel production are not well-documented, its metabolic pathways could provide insights into the development of microbial systems that enhance the efficiency of biofuel generation processes. Overall, the exploration of Bartonella krasnovii in these industrial contexts highlights its significance in advancing both scientific knowledge and practical applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 11

LLM predicted phenotypes: 2

Phenotype	High-quality annotation	google/gemini-pro-1.5	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	FALSE	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerobic ✓	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	gamma	N/A	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	alpha ✗	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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