Mycobacterium pseudokansasii

General Information

Mycobacterium pseudokansasii is a species of nontuberculous mycobacteria (NTM) that has garnered interest due to its close resemblance to Mycobacterium kansasii, a well-known pathogen. One of the most intriguing aspects of M. pseudokansasii is its genetic and phenotypic similarity to M. kansasii, which can complicate diagnosis and treatment. This similarity necessitates advanced molecular techniques for accurate identification, making it a subject of study in clinical microbiology and diagnostic research. Mycobacterium pseudokansasii is also notable for its environmental resilience. It has been isolated from various natural sources, including water and soil, indicating its ability to survive and persist in diverse habitats. This environmental versatility makes it a valuable model for studying microbial ecology and the survival mechanisms of mycobacteria in non-host environments. From a clinical perspective, M. pseudokansasii is of interest due to its potential to cause pulmonary infections, particularly in immunocompromised individuals. Understanding its pathogenic mechanisms and resistance profiles is crucial for developing effective treatments. Research into M. pseudokansasii can provide insights into the broader category of NTM infections, which are increasingly recognized as significant health concerns. In summary, Mycobacterium pseudokansasii is a fascinating organism due to its close resemblance to a known pathogen, its environmental resilience, and its clinical implications. These characteristics make it a valuable subject for research in microbial ecology, clinical microbiology, and infectious disease management.

Mycobacterium pseudokansasii is a non-tuberculous mycobacterium that is part of the Mycobacterium genus, which is known for its complex lipid-rich cell wall. This organism is particularly interesting due to its clinical relevance; it has been associated with pulmonary infections, especially in immunocompromised individuals. Unlike its more notorious relative, Mycobacterium tuberculosis, M. pseudokansasii is less common but can still pose significant health risks, particularly in certain populations. One of the unique aspects of M. pseudokansasii is its genetic diversity and the ability to adapt to various environments, which makes it a subject of interest in microbial ecology and evolution studies. Researchers have noted that this species can exhibit a range of phenotypic characteristics, which complicates its identification and underscores the importance of molecular techniques in microbiology. Furthermore, M. pseudokansasii has been studied for its potential role in bioactive compound production. Some strains have shown the ability to produce substances that may have antimicrobial properties, making them valuable in the search for new antibiotics. This characteristic highlights the organism's potential utility in pharmaceutical research. In summary, Mycobacterium pseudokansasii stands out not only for its clinical implications but also for its ecological adaptability and potential contributions to biotechnology, making it a significant focus for ongoing research in microbiology and infectious diseases.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium pseudokansasii

NCBI ID

2341080

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/566/075/GCA_900566075.1_MK142

File for sequence-based predictions:
GCA_900566075.1_MK142_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium pseudokansasii is a non-tuberculous mycobacterium (NTM) that has been associated with various clinical implications, particularly in immunocompromised individuals. It is known to cause pulmonary infections, which can mimic those caused by Mycobacterium tuberculosis. Patients with underlying lung diseases, such as chronic obstructive pulmonary disease (COPD) or cystic fibrosis, are at increased risk for infection. The clinical presentation often includes symptoms such as chronic cough, hemoptysis, and weight loss, which can lead to a delay in diagnosis due to similarities with other respiratory conditions. In addition to pulmonary disease, M. pseudokansasii has been implicated in cutaneous infections and disseminated disease, particularly in patients with weakened immune systems. The organism's pathogenicity is partly attributed to its ability to evade the immune response, utilizing various strategies such as the modulation of macrophage function and the formation of biofilms, which can protect it from phagocytosis and antimicrobial agents. Antimicrobial resistance is a significant concern with M. pseudokansasii, as it exhibits resistance to multiple first-line antitubercular drugs, complicating treatment options. This resistance necessitates the use of second-line agents, which may have more severe side effects and require prolonged therapy. While M. pseudokansasii is primarily recognized for its pathogenic potential, there is ongoing research into its role in probiotic applications and its potential benefits in certain contexts, although this is not yet well-established. Overall, the clinical relevance of Mycobacterium pseudokansasii underscores the importance of accurate identification and appropriate management of infections caused by this organism.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium pseudokansasii has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium pseudokansasii may play a role in the fermentation of biomass, where it can help convert organic materials into biofuels through fermentation processes. This capability is particularly valuable in the development of sustainable energy sources, as it can utilize various substrates, including agricultural waste. Furthermore, there is ongoing research into the pharmaceutical development potential of Mycobacterium pseudokansasii. Its unique metabolic pathways may lead to the discovery of novel compounds that could be used in drug formulation, particularly in the treatment of infectious diseases. The organism's ability to produce specific metabolites through enzyme production could be harnessed for therapeutic applications. Overall, Mycobacterium pseudokansasii demonstrates significant promise in biotechnology, waste management, biofuel production, and pharmaceutical development, making it a valuable organism for future industrial applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-pro-1.5	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	true	true	false	true	true	true	false	false	false	false	true	true	true	false	false	false	false	true	true	true	true	true	true	true	true	true
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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