Mycobacterium sherrisii

General Information

Mycobacterium sherrisii is a fascinating microorganism within the genus Mycobacterium, which includes notable species such as Mycobacterium tuberculosis and Mycobacterium leprae. What makes M. sherrisii particularly interesting is its role in causing non-tuberculous mycobacterial (NTM) infections, which are increasingly recognized as significant pathogens in both immunocompromised and immunocompetent individuals. One of the key characteristics of M. sherrisii is its slow growth rate, which is typical of many mycobacteria. This slow growth can complicate diagnosis and treatment, as it requires prolonged culture times to identify the organism accurately. Another noteworthy feature of M. sherrisii is its unique genetic profile. Molecular studies have shown that it has distinct genetic markers that differentiate it from other closely related mycobacteria. This genetic uniqueness is valuable for researchers aiming to understand the evolutionary pathways and genetic diversity within the Mycobacterium genus. From a clinical perspective, M. sherrisii is known to cause pulmonary infections, which can mimic tuberculosis, making accurate diagnosis crucial for effective treatment. It has also been isolated from cutaneous and soft tissue infections, highlighting its versatility and adaptability to different host environments. In terms of antibiotic resistance, M. sherrisii exhibits a pattern that is somewhat distinct from other mycobacteria, necessitating tailored antibiotic regimens for effective treatment. This aspect makes it a subject of ongoing research, particularly in the development of new antimicrobial therapies. Overall, Mycobacterium sherrisii is a microorganism of significant interest due to its clinical implications, genetic distinctiveness, and the challenges it presents in diagnosis and treatment. Its study not only enhances our understanding of NTM infections but also contributes to the broader field of mycobacterial research.

Mycobacterium sherrisii is a lesser-known species within the genus Mycobacterium, which is renowned for its role in various infectious diseases, including tuberculosis. This particular species was first described in 1995 and is notable for its unique ecological niche and potential implications in environmental microbiology. One of the most interesting aspects of M. sherrisii is its ability to thrive in specific environmental conditions, which may provide insights into the adaptability of mycobacteria in diverse habitats. The organism has been isolated from soil and is believed to play a role in the degradation of complex organic materials, showcasing its potential utility in bioremediation efforts. This characteristic makes M. sherrisii a valuable subject for research in environmental science, particularly in understanding how microorganisms can contribute to ecosystem health and sustainability. Furthermore, the genetic and metabolic pathways of M. sherrisii are of interest to researchers studying the evolutionary adaptations of mycobacteria. Its unique genetic makeup may offer clues about the mechanisms of resistance to environmental stressors, which is crucial for developing strategies to combat pathogenic mycobacteria. Overall, Mycobacterium sherrisii stands out as a fascinating organism that bridges the gap between environmental microbiology and potential applications in biotechnology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium sherrisii

NCBI ID

243061

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/025/822/045/GCF_025822045.1_ASM2582204v1

File for sequence-based predictions:
GCF_025822045.1_ASM2582204v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium sherrisii is a member of the Mycobacterium genus, which is known for its clinical significance primarily in relation to infections and disease associations. While it is less commonly discussed than its more notorious relatives, such as Mycobacterium tuberculosis, M. sherrisii has been implicated in rare cases of pulmonary infections and may be associated with opportunistic infections in immunocompromised individuals. Pathogenicity is a key concern, as this organism can evade the immune response through various mechanisms, including the modulation of host cell signaling pathways and the ability to survive within macrophages. In terms of antimicrobial resistance, there is limited data available, but like many mycobacteria, it may exhibit resistance to common antibiotics used in the treatment of mycobacterial infections. This raises concerns for effective treatment options, particularly in patients with compromised immune systems. Furthermore, the role of M. sherrisii in human health is still being explored, and while it is not widely recognized as a probiotic or therapeutic agent, understanding its interactions with the human body could provide insights into potential medical applications in the future. Overall, the clinical implications of Mycobacterium sherrisii underscore the importance of continued research into its pathogenic potential and the need for awareness in clinical settings.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium sherrisii is a species of bacteria that is primarily associated with human-associated environments and clinical settings. This microorganism is often found in urban areas where it can thrive in environments influenced by human activity, particularly in regions with high population density and varying levels of sanitation. Its presence is notably linked to respiratory infections, indicating its adaptation to the human respiratory tract as a niche habitat. In terms of ecological interactions, Mycobacterium sherrisii plays a role in the microbial community of the human microbiome, where it may engage in competitive interactions with other microbial species. This can influence the overall health of the host, as well as the dynamics of microbial populations in the respiratory system. The organism's ability to survive in aerobic conditions and its resistance to certain environmental stresses allow it to persist in these habitats. Furthermore, Mycobacterium sherrisii is of interest in the study of pathogenicity and antibiotic resistance, making it a significant organism in medical microbiology. Its interactions with the host immune system can lead to various outcomes, including chronic infections, which highlight its role in the broader context of human health and disease ecology.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium sherrisii has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium sherrisii may play a role in the fermentation of biomass, converting organic materials into biofuels through fermentation processes. This capability is particularly valuable in the development of sustainable energy sources, as it can help in the conversion of agricultural waste into usable fuel. Additionally, there is potential for Mycobacterium sherrisii in pharmaceutical development, where its unique metabolic pathways could be harnessed for the production of bioactive compounds. The organism's ability to synthesize specific metabolites may lead to the discovery of new drugs or therapeutic agents. Overall, the applications of Mycobacterium sherrisii in these industries highlight its significance in advancing environmental sustainability and contributing to innovative biotechnological solutions.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	N/A
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	true	false	false	true	false	true	true	true	true	false	false	true	true	false	false	false	false	false	false	false	false	true	true	true	true	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Host association	N/A	true	true	true	true	true	true	true	false	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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