Mycobacterium nebraskense

General Information

Mycobacterium nebraskense is a species of nontuberculous mycobacteria (NTM) that has garnered attention due to its clinical significance and unique characteristics. This organism was first isolated from human clinical specimens, indicating its potential role in human disease. One of the most notable aspects of M. nebraskense is its association with pulmonary infections, particularly in immunocompromised individuals or those with pre-existing lung conditions. The bacterium is slow-growing, which can complicate diagnosis and treatment, as it requires specialized culture techniques and extended incubation periods. Its colonies are typically smooth and non-pigmented, distinguishing it from other mycobacteria that may produce pigmented colonies. From a research perspective, M. nebraskense is valuable for studying the pathogenesis of NTM infections and the host immune response. Understanding how this organism interacts with the human immune system can provide insights into the mechanisms of chronic lung infections and help develop targeted therapies. Additionally, its resistance to common antibiotics used for treating mycobacterial infections makes it a critical subject for antimicrobial resistance studies. In summary, Mycobacterium nebraskense is a clinically significant NTM with unique characteristics that make it an important focus for research into pulmonary infections, immune response, and antibiotic resistance.

Mycobacterium nebraskense is a species of the genus Mycobacterium that has garnered interest due to its unique ecological niche and potential implications in environmental microbiology. This organism is particularly notable for its ability to thrive in soil and water environments, which distinguishes it from many other members of the Mycobacterium genus that are primarily associated with pathogenicity in humans and animals. One of the most intriguing aspects of M. nebraskense is its capacity to degrade complex organic compounds, making it a valuable player in bioremediation processes. This ability to metabolize various pollutants positions it as a potential candidate for use in environmental cleanup efforts, particularly in areas contaminated with hydrocarbons or other organic pollutants. Additionally, M. nebraskense has been studied for its unique lipid composition, which includes mycolic acids that are characteristic of the Mycobacterium genus. These lipids not only contribute to the organism's structural integrity but also play a role in its interactions with other microorganisms and the environment. Research into M. nebraskense has also revealed its potential biotechnological applications, particularly in the production of bioactive compounds. The metabolic pathways utilized by this organism may lead to the discovery of novel antibiotics or other therapeutic agents, making it a subject of interest in pharmaceutical research. In summary, Mycobacterium nebraskense stands out due to its ecological versatility, bioremediation potential, unique lipid profile, and promising biotechnological applications, making it a significant organism for further study in both environmental and medical microbiology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium nebraskense

NCBI ID

244292

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/021/495/GCF_001021495.1_ASM102149v1

File for sequence-based predictions:
GCF_001021495.1_ASM102149v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium nebraskense is a member of the Mycobacterium genus, which is known for its clinical significance in human health. While it is not as widely recognized as other mycobacteria, such as Mycobacterium tuberculosis, M. nebraskense has been associated with pulmonary infections and cutaneous lesions, particularly in immunocompromised individuals. Clinical implications of M. nebraskense include its potential role in opportunistic infections, especially in patients with underlying health conditions or weakened immune responses. One of the notable aspects of M. nebraskense is its pathogenicity, which can lead to chronic infections that may be difficult to diagnose and treat. The organism exhibits some degree of antimicrobial resistance, complicating treatment options. This resistance is particularly concerning in the context of mycobacterial infections, where standard therapies may be less effective. In terms of immune evasion strategies, M. nebraskense may utilize mechanisms similar to other mycobacteria, such as the ability to survive within macrophages and evade the host's immune response. This characteristic allows it to persist in the body and contribute to chronic disease states. While there is limited information on specific outbreaks associated with M. nebraskense, its identification in clinical specimens underscores the importance of considering this organism in differential diagnoses for patients presenting with respiratory or skin-related symptoms. Further research is needed to fully understand its epidemiology and potential role in human disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium nebraskense is a species of bacteria that is primarily associated with soil environments and water systems. This microorganism thrives in nutrient-rich soils and is often found in areas with high organic matter content, such as decaying plant material and wetlands. Its presence is indicative of a healthy ecosystem, as it plays a crucial role in the decomposition process and nutrient cycling within these habitats. In terms of ecological interactions, Mycobacterium nebraskense is known for its ability to form symbiotic relationships with various plants and fungi. This symbiosis can enhance nutrient uptake for the host organisms, particularly in nutrient-poor soils, thereby promoting plant growth and biodiversity. Additionally, this bacterium can contribute to the bioremediation of contaminated environments, as it has been shown to degrade certain pollutants, thus improving soil and water quality. Furthermore, Mycobacterium nebraskense exhibits remarkable environmental adaptability, allowing it to survive in a range of conditions, from aerobic to anaerobic environments. This adaptability is crucial for its survival in fluctuating habitats, such as those found in seasonal wetlands or floodplains, where water levels and nutrient availability can vary significantly. Overall, Mycobacterium nebraskense is an important component of its associated biomes, contributing to ecological balance and health through its roles in decomposition, nutrient cycling, and environmental remediation.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium nebraskense has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium nebraskense may play a role in the fermentation of biomass, converting organic materials into biofuels through fermentation processes. This capability is particularly valuable in the development of sustainable energy sources, as it can help in the conversion of agricultural waste into usable fuel. Additionally, there is potential for Mycobacterium nebraskense in pharmaceutical development, where its unique metabolic pathways could be harnessed for the production of bioactive compounds. The organism's ability to synthesize various secondary metabolites may lead to the discovery of new drugs or therapeutic agents. Overall, the applications of Mycobacterium nebraskense in these industries highlight its significance in promoting environmental sustainability and advancing biotechnological innovations.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	openai/gpt-4	openai/gpt-4	google/gemini-pro	google/gemini-pro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	true	false	false	false	true	true	true	false	false	true	true	false	false	true	true	false	false	false	false	false	false	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	true	true	false	false	true	true	false	false	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	false	false	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

Back to Search