Leptospira dzoumogneensis

General Information

Leptospira dzoumogneensis is a species of bacteria within the genus Leptospira, which is known for its distinctive helical shape. This organism is particularly interesting due to its role in the broader context of leptospirosis, a zoonotic disease that affects both humans and animals. Leptospira species are renowned for their ability to survive in a variety of environmental conditions, which makes them a subject of extensive research in environmental microbiology and epidemiology. One of the unique aspects of Leptospira dzoumogneensis is its genetic makeup, which provides insights into the evolutionary pathways of pathogenic and non-pathogenic strains within the genus. The study of its genome can reveal important information about the mechanisms of virulence, adaptation, and survival in diverse habitats. This makes Leptospira dzoumogneensis valuable for comparative genomic studies aimed at understanding the genetic determinants of pathogenicity. From a research perspective, Leptospira dzoumogneensis is also significant due to its potential use in developing diagnostic tools and vaccines. Understanding its antigenic properties can lead to the identification of novel biomarkers for more accurate and rapid detection of leptospirosis. Additionally, studying its interactions with host organisms can provide critical insights into the immune response and pathogenesis of leptospiral infections. In summary, Leptospira dzoumogneensis stands out due to its ecological versatility, genetic insights, and potential applications in medical research, making it a valuable organism for scientific exploration.

Leptospira dzoumogneensis is a fascinating species within the genus Leptospira, known for its unique ecological niche and potential implications in public health. This organism is primarily associated with aquatic environments, particularly in tropical regions, where it thrives in freshwater ecosystems. Its ability to survive in such habitats makes it an important subject of study for understanding the dynamics of waterborne pathogens. One of the most interesting aspects of L. dzoumogneensis is its role in the transmission of leptospirosis, a zoonotic disease that can affect both humans and animals. The organism is often found in association with various animal hosts, particularly rodents, which serve as reservoirs. This relationship highlights the importance of studying L. dzoumogneensis in the context of zoonotic disease transmission and environmental health. From a research perspective, Leptospira dzoumogneensis offers valuable insights into the genetic diversity and evolutionary adaptations of the Leptospira genus. Its genome can provide information on the mechanisms of pathogenicity and resistance to environmental stressors, which are crucial for developing effective control measures against leptospirosis. Furthermore, understanding the ecological interactions of L. dzoumogneensis can aid in predicting outbreaks and managing public health risks associated with water contamination. In summary, Leptospira dzoumogneensis stands out due to its ecological significance, its role in disease transmission, and its potential contributions to our understanding of microbial evolution and public health challenges. Its study is essential for both environmental microbiology and epidemiology.

Taxonomy

Superkingdom: Bacteria

Phylum: Spirochaetota

Class: Spirochaetia

Order: Leptospirales

Family: Leptospiraceae

Genus: Leptospira

Species: Leptospira dzoumogneensis

NCBI ID

2484904

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/004/770/895/GCF_004770895.1_ASM477089v1

File for sequence-based predictions:
GCF_004770895.1_ASM477089v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Leptospira dzoumogneensis is a species of the genus Leptospira, which is known to be associated with leptospirosis, a significant zoonotic disease. This organism has been identified in various environmental sources, particularly in tropical and subtropical regions, where it can be transmitted to humans through contact with contaminated water or soil. The clinical implications of Leptospira dzoumogneensis include its potential to cause a range of symptoms, from mild flu-like manifestations to severe disease characterized by hemorrhagic fever, renal failure, and hepatic dysfunction. In terms of pathogenicity, Leptospira dzoumogneensis can evade the host's immune response through various mechanisms, including the production of surface proteins that inhibit phagocytosis and the ability to survive in the host's bloodstream. This evasion contributes to the organism's virulence and complicates the clinical management of infections. Moreover, there is growing concern regarding antimicrobial resistance among Leptospira species, which may limit treatment options for infected individuals. While specific resistance mechanisms for Leptospira dzoumogneensis are not extensively documented, the potential for resistance development underscores the need for ongoing surveillance and research. In terms of medical applications, understanding the epidemiology and pathogenic mechanisms of Leptospira dzoumogneensis is crucial for developing effective vaccines and therapeutics against leptospirosis. Public health measures aimed at controlling outbreaks and preventing transmission are also essential, particularly in endemic regions where the risk of infection is heightened.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Leptospira dzoumogneensis has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is part of the genus Leptospira, which is known for its unique metabolic capabilities and adaptability to different environments. In biotechnology, Leptospira dzoumogneensis can be utilized in biodegradation processes, where it may help in the breakdown of complex organic compounds, making it valuable for the treatment of contaminated environments. Its ability to metabolize various substrates can be harnessed for the development of bioremediation strategies aimed at cleaning up polluted sites, particularly those contaminated with heavy metals or organic pollutants. In the realm of waste management, this microorganism can play a role in wastewater treatment, where it may assist in the degradation of organic matter, thus improving the efficiency of treatment systems. The use of Leptospira dzoumogneensis in such processes can lead to reduced sludge production and enhanced nutrient removal, contributing to more sustainable waste management practices. Furthermore, there is potential for Leptospira dzoumogneensis in pharmaceutical development, particularly in the production of bioactive compounds. The organism's unique metabolic pathways may lead to the discovery of novel antibiotics or other therapeutic agents, which could be beneficial in combating resistant strains of bacteria. Overall, while research on Leptospira dzoumogneensis is still emerging, its applications in biotechnology, waste management, and pharmaceutical development highlight its significance in various industrial sectors, particularly in processes involving fermentation, biodegradation, and enzyme production.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	google/gemma-7b-it	google/gemma-7b-it	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	google/gemini-pro	google/gemini-pro	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	anaerobic	N/A	aerobic ✗	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✗	aerobic ✗	aerobic ✗	aerobic ✗	N/A	N/A	aerobic ✗	aerobic ✗	N/A	aerobic ✗	aerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	false	false	true	true	true	true	true	false	false	true	true	true	true	true	true	true	false	false	true	true	false	false	false	false	true	true
Animal pathogenicity	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	beta	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	spirillum	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	bacillus ✗	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	bacillus ✗	bacillus ✗	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	bacillus ✗	bacillus ✗	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	N/A	N/A

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